School of Medicine

Wayne State University School of Medicine

Dr. Ajay Kumar, MD, DNB, PhD, MNAMS

   

     

      Presently, I am working as an Assistant Professor in the department of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, MI, USA, since January 2009 and as a physician in Positron Emission Tomography (PET) Center, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI, USA. I completed my MD (General Medicine)from Second Tashkent State Medical Institute, Tashkent, Uzbekistan. Then I received MD (Biophysics), MD(DNB) (Nuclear Medicine)and PhD (Nuclear Medicine)from All India Institute of Medical Sciences (AIIMS), New Delhi, India. Subsequently, I joined department of Pediatrics and Neurology, School of Medicine, Wayne State University, as a post-doc fellow from July 2006 to Dec 2008, and then as an Assistant professor.

      I am well versed not only with Internal Medicine and entire spectrum of Nuclear Medicine, I am equally comfortable with high level of computation including dosimetry, mathematical modeling & tracer kinetics, statistical analyses and various image processing softwares. Presently, I am involved in the interpretation and analysis of PET-CT scans, using various radiotracers, in patients with cancers and various brain disorders, and evaluation of brain white matter with diffusion tensor imaging (DTI), including tractography. I am also involved in several grant preparation and submission, including permissions from our institute’s review board and am a co-investigator in an NIH-funded grant regarding evaluation of children with tuberous sclerosis using alpha-methyl tryptophan (PI: Dr Harry T Chugani, MD).

     My particular strength and expertise lies in brain PET, particularly pediatric brain PET using different PET tracers, such as 18F-FDG (for glucose metabolism), 11C-flumazenil (for benzodiazepine receptors), 11C-alpha-methyltryptophan (for serotonin and kinurenine metabolism), 11C-Leucine (for protein synthesis), 11C-PK11195 (for brain inflammation), etc. Our center is one of the leading pediatric PET centers in the world and people from all around the US and many different countries come to our center for these various PET scans. I have a special interest in the evaluation of neuroinflammation using 11C-PK11195 PET in children with neurological disorders, such as epilepsy, autism, Nieman Pick disease type-C, leukodystrophy, PANDAS, etc, and ours is one of the few PET centers in the world where this kind of study is performed. My works regarding 11C-PK11195 PET evaluation of neuroinflammation have been published in various peer-reviewed journals, including “Journal of Nuclear Medicine”, ranked first in the world among imaging journals and "Pediatric Neurology", a leading pediatric neurology journal. I am also responsible for the analysis and interpretation of 11C-alpha-methyltryptophan (AMT) PET scan in children with tuberous sclerosis and intractable epilepsy; a study unique in identifying the epileptic tuber and thus helping in epilepsy surgery planning, and being performed at only few centers in the world and patients, from as far as Australia, Norway and Argentina, routinely come to our center for this particular PET imaging. In a recent study, I also demonstrated that AMT PET scan can non-invasively identify cortical dysplasia (Taylor type IIB) in children with intractable epilepsy, thus greatly helping in treatment planning and prognostication. This work was published in "Epilepsia", the leading epilepsy journal. I also evaluated the role of voxel based analysis, such as statistical parametric mapping (SPM), of FDG PET images in the presurgical lateralization and localization of epileptic foci in children with intractable epilepsy using normal adult FDG images as controls. I demonstrated that such objective analysis is possible in children more than 6 years of age, even in the absence of age-matched controls, and can be a very useful complement to the visual analysis. This work has been published in the “Journal of Nuclear Medicine”. I also conducted a study of memory localization in human brain with the help of 11C-leucine brain PET scan, whose results were partially presented at the 9th Congress of Asia Oceania Federation of Nuclear Medicine & Biology 2008, in New Delhi, India.

      I am also extensively using DTI-MRI to evaluate neuronal pathways or circuitries. Recently, I determined the origin and course of the cortico-spinal tracts using DTI tractography in a large number of healthy children and children with focal epilepsy to address the controversy surrounding century old traditional belief that corticospinal tract arises from pre-central gyrus and passes through the anterior half of the posterior limb of the internal capsule. We also validated the DTI Tractography outcomes using cortical stimulation in children with focal epilepsy. I found that the corticospinal tract most frequently originates from both pre-central and post-central gyri and the corticospinal tracts typically go through not the anterior but posterior portion of the posterior limb of internal capsules, bilaterally. In addition, I also quantitatively measured the ontogenic changes of DTI measures in a large number of healthy children. I believe that these results have increased our understanding of the anatomy of corticospinal tracts in relation to the primary motor cortex and will be of great interest and help to researchers and clinicians, particularly, epileptologists and epilepsy surgeons. This work has been published in “American Journal of Neuroradiology”, a leading neuroimaging journal. In another study, I analyzed the frontal lobe association tracts and corpus callosum in patients with autism and had some very significant and interesting findings, which I think may help in understanding the neuroanatomic basis of autistic features. These findings were published in “Cerebral Cortex”, a very prestigious and leading neuroscience journal. I have also evaluated neuronal connectivity using DTI-MRI in children with early deprivation to find the effect or orphanage on neuronal circuitry and its relationship with various neuro-cognitive outcomes. These are only some of the examples of my extensive work involving PET and DTI-MRI.

       During my stay at the department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India, I participated in all the diagnostic and therapeutic activities of the department and was actively involved in numerous clinical trials such as, optimization of radioiodine dose for remnant thyroid ablation in differentiated thyroid cancer, role of lithium and ipanoic acid in the radioiodine treatment of hyperthyroidism, role of 99m-Tc-DMSA in the evaluation of renal scar in diabetic patients, role of 99m-Tc-MDP bone scan/SPECT along with MRI in the evaluation of low back ache, clinical evaluation of 99m-Tc-LLEC (a glomerular agent) renal scan as a single modality to assess renal function and morphology simultaneously, role of gastroesophageal study and gastric emptying study in gastric motility disorders and post-gastric surgery, evaluation of post-traumatic bone healing with 99m-Tc-MDP bone scan/SPECT, role of 99m-Tc-DTPA GFR studies in the evaluation of patients with chronic renal failure and anaemia, etc., the results of which have been published in various peer-reviewed international scientific journals. I was also actively involved in red blood cell mass estimation and red blood cell survival studies in patients with various haematological disorders such as Thalassemia, Polycythemia, etc.; studies done only in that department in whole of India,.

       The department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India, conducts the largest number of nuclear neuro-imaging studies in India. These include brain imaging in patients with intractable epilepsy using ictal and interictal Tc99m ECD/HMPAO SPECT with use of MATLAB and SPM for SISCOM/SISCOS. During my residency there, I was actively involved in a multicentric study, conducted by International Atomic Energy Agency, on comparative evaluation of Ictal brain SPECT, EEG, MRI and CT scan in the management of patients with refractory seizures in India. Besides, I also actively participated in clinical trials evaluating the role of 99m-Tc-HMPAO/ECD brain SPECT in children with attention deficit hyperactivity disorder, patients with hypertension, hyperlipidaemia, and the role of 99m-Tc-ECD, GHA & TF in differentiating remnant/recurrent tumor vs necrotic/fibrotic tissue after surgery/radiotherapy/chemotherapy in patients with brain tumor.

       I underwent training in radioiodine therapy of thyroid carcinoma and hyperthyroidism during my residency. During this period I was responsible for clinical evaluation of these patients, administration of therapeutic radio-iodine and in their post-therapy follow-up. Till 2006 more than 2800 thyroid cancer patients and 3200 hyperthyroid patients had undergone therapy and were on regular follow-up at thyroid clinic, All India Institute of Medical Sciences, New Delhi, India; the largest center in India for this purpose. I was actively associated with a randomized control trial to determine the lowest possible dose of radioiodine (131I) required for remnant ablation in patients with differentiated thyroid cancer, whose results have been published in the April 2004 issue of JCEM and have led to the world wide downward change in the administered radioiodine activity for this purpose. In another clinical trial, where I was actively associated, we demonstrated that radioiodine ablation of intact thyroid lobe is possible in thyroid cancer patients having undergone hemithyroidectomy and lobar ablation can be an attractive alternative to surgery for those who refuse to undergo completion thyroidectomy or had complication during initial surgery (published in Feb 2003 in Nucl Med Comm). Similarly, in a subsequent study, we showed that remnant thyroid ablation with radioiodine is possible after subtotal thyroidectomy also, thus reducing the chance of future recurrences and metastasis. Therefore, patient undergoing subtotal thyroidectomy can also benefit from the radioiodine therapy, which was not given to them till now. The results were published in Aug 2006 issue of Acta Oncologica. I also participated in the assessment of Tc99m-tetrofosmin and sestaMIBI as an alternative to radioiodine whole body scan in the follow-up of patients with thyroid carcinoma after radioiodine-ablation. In another study, we evaluated the fertility and genetic risk to the offspring from the exposure of high dose radioiodine, by assessing the pregnancy outcomes and health status of the children of female patients with DTC who had received therapeutic doses of radioiodine. We found that radioiodine treatment of differentiated thyroid cancer doesn’t affect the female fertility and doesn’t appear to be associated with any genetic risk to the offspring, thus allaying the apprehensions of female patients who would want to have children after radioiodine treatment of thyroid cancer. The results have been published in October 2005 issue of Int J Radiat Oncol Biol Phys, the number one journal in radiotherapy and have been extensively quoted in scientific and general literature. I also extensively studied the clinical features and characteristics of differentiated thyroid carcinoma in children and adolescents and tried to define the disease. Most of the patients in our study belonged to mild to moderate endemic iodine deficiency sub-Himalayan endemia, therefore I also tried to see, how iodine deficiency affects the development and clinical course of the disease and what implication it has on radioiodine neck uptake and radioiodine therapy. This was the only study of this type to be done from India and its findings shed important light on various aspects of the disease and helped in formulating an appropriate treatment strategy. I found that the incidence of differentiated thyroid carcinoma, particularly follicular variant is relatively higher in children and adolescents from endemic iodine deficient area. Younger the age (<10 years), more aggressive and widespread is the disease with male preponderance and high mortality (25%). In older children (>10 years), clinical course and prognosis appears to be same as in children from iodine sufficient area. The Post-surgical radioiodine ablation/therapy seems important and effective adjuvant in the management of differentiated thyroid cancer in children and adolescents. Part of this work was accepted for presentation in 7th congress of Asia-Oceania Federation of nuclear medicine & biology, held at Istanbul, Turkey from 1-5th Oct 2000 and I was awarded Young Scientist/Travel grant award for it. My findings, subsequently, got published in August 2001 issue of Nucl Med Communications. Subsequently, we critically reviewed the clinical characteristics, pattern of disease at presentation, histopathological subtype, treatment, course & outcome of differentiated thyroid cancer in children and adolescents presenting with pulmonary metastasis and compared radioiodine WBS with x-ray and CT chest in the diagnosis/evaluation of pulmonary metastasis. We found that a large number of children and adolescents with differentiated thyroid cancer present with pulmonary metastasis and majority of them could be missed on routine chest x-rays and even on CT scans. However, they can be detected by radioiodine whole body scan, as these metastases avidly concentrate radioiodine. We also found that these metastases usually respond very well to the radioiodine treatment. Therefore, we recommended a routine post-surgical evaluation with radioiodine WBS in all children so that any pulmonary metastases can be detected at the earliest and be dealt with promptly, thus reducing long term morbidity and mortality. Our findings were published in March 2004 issue of ‘Thyroid’ and have led to considerable change in approach and management of children with thyroid cancer.

      I was also involved in a randomized control trial to evaluate the role of lithium as an adjuvant in the radioiodine treatment of hyperthyroidism. We found that the role of lithium as an adjuvant was insignificant and it should not be used, thus sparing the patient with possible serious side effects of lithium. In another randomized controlled trial, we assessed the effect of Iopanoic Acid (Telepaque) on radioiodine therapy of hyperthyroidism and its long-term outcome. We found that Telepaque can be used for rapid control of hyperthyroidism without any significant adverse effects or jeopardizing the subsequent radioiodine therapy and the long-term outcome of radioiodine therapy in this subset of patients was no way different compared to those prepared by conventional methods (published in Dec 2005 issue of JCEM). It paved the way for use of ipanoic acid in making severely hyperthyroid patient euthyroid quickly, thus relieving them of their symptoms as well as rendering them suitable for subsequent radioiodine therapy, a permanent cure of this condition. It is worthwhile to note that no other alternative is available, as of today, which can as quickly alleviate the symptoms of severe hyperthyroidism. I have also independently administered P-32/Sr-89/Sm-153 therapy for skeletal metastases and intra-articular Y-90/Re-188 for radiosynevectomy in cases of arthritis.

     I did my PhD on “Dosimetric and Therapeutic Evaluation of Trans-Arterial Rhenium-188 in Cases of Inoperable Hepatocellular Carcinoma (HCC)”, a multicentric trial conducted by IAEA, which was first of its kind in that part of the world. I was personally involved in the clinical work-up, radiolabelling (of Re-188 with lipiodol), dosimetry, transarterial therapy and follow-up of liver cancer patients. I was involved in the radiological evaluation of the patients with triple phase CT scan using various reconstruction techniques such as multiplanar image reconstruction (MPR) and maximum intensity projection (MIP) and DSA guided injection of Re-188-lipiodol into the tumor after hepatic artery catheterisation. During the course of this work, I modified and simplified the dosimetric and labeling techniques, which was discussed and accepted in a IAEA research co-ordination meeting held in Dec 2003 in New Delhi, published in April 2004 issue of World Journal of Nuclear Medicine and now being followed by other participating countries. The results of my study were encouraging and promising and it appeared that besides having better and favorable physical characteristics, Re-188 also has good tumoricidal effect which was associated with increased survival. With our study, we demonstrated that with individual dosimetry, one can safely administer the maximum possible amount of Re-188-HDD-lipiodol to the tumor without jeopardizing other organs and in patients where dosimetry is not possible, empirically around 5.5 GBq (150 mCi) of activity can be safely administered as it will deliver adequate radiation dose to the tumor in most of the patients. We demonstrated that Re-188-HDD-lipiodol therapy in HCC is safe, effective and promising therapeutic option in patients with inoperable large and/or multifocal HCC, thus opening a new vista and giving hope to millions of such patients who had hitherto not much therapeutic options. We also found that besides using trans-arterial Rhenium-188-lipiodol therapy for palliative treatment of large tumors, it may be used to manage portal vein thrombosis (published in Nov 2005 issue of European Journal of Radiology Extra) and sometimes with curative intent for multiple but small and inoperable tumors (published in Feb 2006 issue of Eur J Gastroenterol Hepatol). Part of my work was accepted for platform presentation in the 51st annual meeting of Society of Nuclear Medicine (SNM), the most prestigious body of Nuclear Medicine, held in June 2004 at Philadelphia, USA and was selected for the highlight session. It has been published in May 2007 issue of “Radiology”, one of the best and most esteemed journals with very high impact factor and again as part of the whole multicenter trial in Dec 2007 issue of Int J Radiat Oncol Biol Phys and March 2008 issue of Seminars in Nuclear Medicine, the most respected journal in Nuclear Medicine. I was awarded first prize of “young Professional Award” for my PhD work by the Society of Nuclear Medicine in 2006. I am the first scholar from India to be honored with this award.

      Throughout my residency, PhD and thereafter, I orally presented numerous seminars covering the entire spectrum of nuclear medicine and have actively participated in various other teaching programs. I have numerous high quality scientific & widely acclaimed publications, including review articles in reputed national and international journals. I have also written many chapters in textbooks for Nuclear Medicine, Biochemistry, Pediatrics, Neurology and Surgery, which are read by medical students and professionals. Recently, I wrote a chapter about PET imaging in seizure analysis, in “Encyclopedia of Basic Epilepsy Research” by Elsevier Ltd, Oxford, UK, which will work as a reference and guide for people working with epilepsy worldwide. I have received several young scientist/investigator awards from various professional bodies such as International thyroid Congress, Indo-American Society of Nuclear Medicine, Asia Oceania Federation of Nuclear Medicine and Biology, International Atomic Energy Agency (IAEA), Society of Nuclear Medicine, Radiological Society of North America, National Institute of Health, US, etc, including “Young Investigator Travel Award”, for my work on evaluation of neuroinflammation using C-11-[R]-PK11195 PET scan in children with Niemann Pick disease type-C, from society of Nuclear Medicine, in a molecular imaging symposium at NIH, Bethesda, USA and “Molecular Imaging travel award” for my work “Uptake pattern, Tracer Kinetics and Receptor Binding of C-11-[R]-PK11195 in the Brain of Children and Adults” from Radiological Society of North America, in Chicago, IL, in year 2010. Same year, my work “Evaluation of cerebellar serotonin synthesis capacity using AMT PET scan in children with autism spectrum disorder” was selected for ‘Brain Imaging Council Young Investigator Award Symposium’ in the 57thannual meeting of the Society of Nuclear Medicine, in Salt Lake City, Utah, from 5-9 June, 2010. I have presented my works in several international conferences and congresses and was invited as a speaker to deliver a lecture on radionuclide management of inoperable hepatocellular carcinoma at an international workshop organized by IAEA in 2003 in New Delhi and by World Radiopharmaceutical therapy council to deliver a plenary lecture in the International symposium on radiopharmaceutical therapy-2008 in Goa, India. Recently, I was invited to deliver a lecture for NINDS autism-epilepsy workshop at National Institute of Health, Bethesda, USA. My work regarding neuroinflammation in children with NPC has been also highlighted and covered by online press:

http://www.healthimaging.com/index.php?option=com_articles&view=article&id=22038:mns-pet-identifies-neuroinflammation-in-children-with-npc-disease

 

Below is my resume with list of publications.


HOSPITAL OR OTHER PROFESSIONAL APPOINTMENTS

-Resident doctor in Safdarjung hospital, New Delhi, India (1996-97)

-Resident doctor in S M Hospital, New Delhi, India (1997-98)

-Resident doctor in All India Institute of Medical Sciences, New Delhi, India (1998-2001)

-Research Officer in All India Institute of Medical Sciences, New Delhi, India (2001-03)

-Senior Research Officer in All India Institute of Medical Sciences, New Delhi, India (2003-06)

-Research Associate in the Dept of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, MI, USA, (2006-08)

-Assistant Professor in the Dept of Pediatrics and Neurology, School of Medicine, Wayne State University, Detroit, MI, USA (Jan, 2009 - )

-PET Fellow in the PET center, Dept of Radiology, School of Medicine Wayne State University, Detroit, MI, USA (Nov, 2010 - )

- House Physician, PET Center, Children's Hospital of Michigan, Detroit Medical Center, Detroit, USA (Jan, 2012- )

 

LICENSURE

-Licensed (#MCI/******) to practice and teach General Medicine (by Medical Council of India)

-Licensed (#**/2001) to practice and teach Biophysics (by All India Institute of Medical Sciences, India)

-Licensed (#****/2005) to practice & teach Nuclear Medicine (by National Board of Examination, India)

-Clinical Academic license (#**********) to practice medicine from Board of Medicine, MI, USA

-Controlled substance (Pharmacy) license (#**********) from Board of Medicine, MI, USA

- Controlled substance registration (#FK*******) from DEA, US dept of Justice, USA

-NPI registration (#**********), USA

 

MEMBERSHIP OF MAJOR PROFESSIONAL SOCIETIES

-Society of Nuclear Medicine, India (A-39)

-Indian Biophysical Society (IBS/L-461)

-Indian College of Nuclear Medicine (No. 102/04-03-2000)

-National Academy of Medical Sciences, India (Ref No: 29-(3)/2004/NAMS/04-18-2005)

-American Epilepsy Society (AES ID# 74949)

-Society of Nuclear Medicine, USA (# 320805)

-Radiological Society of North America (# 00505699)

 

HONORS/AWARDS

  1. Merit Scholarship in School and college
  2. Full Scholarship to study medicine (MD) by Medical Council of India, Gvt. of India.
  3. Completed MD (General Medicine) with ‘Honors’.
  4. Young Scientist/Travel grant award in 2000 from Asia-Oceania Federation of nuclear  medicine & biology.
  5. Young Scientist/Travel grant award in 2000 from 12th International Thyroid Congress, Kyoto, Japan.
  6. Travel Fellow-ship award in 2002 from Indo-American Society of Nuclear Medicine.
  7. My work was selected for presentation in the “highlight session” by Prof Henry Wagner, in 51st and 57th annual meeting of Society of Nuclear Medicine in 2004 and 2009, respectively.
  8. Young Scientist award in year 2003 from Asian Regional Cooperative Council for Nuclear Medicine.
  9. Was made member of National Academy of Medical Sciences, New Delhi, India in 2005.
  10. First prize of “young Professional Award” in 2006 from Society of Nuclear Medicine, US.
  11. Invited by World Radiopharmaceutical Therapy Council to deliver “plenary lectures” in the International symposium on radiopharmaceutical therapy-2008 in Goa, India.
  12. Travel award from Molecular Neuroimaging Symposium, NIH, Bethesda, US, in 2010.
  13. My work was selected for ‘Brain Imaging Council Young Investigator Award Symposium’ in the 57th annual meeting of Society of Nuclear Medicine at Salt Lake City, UT, in 2010.
  14. Molecular Imaging travel award from Radiological Society of North America in Chicago in 2010.

 

REVIEWER (ad-hoc) for peer-reviewed international scientific journals


 

-Annals of Neurology

-Archives of Disease in Childhood

-Biological Psychiatry

-Brain

-Brain and Development

-Developmental Medicine & Child Neurology

-Epilepsia

-Epilepsy Research

-European Journal of Pediatric Neurology

-International Journal of Hepatology

-Journal of the American Academy of Child and Adolescent Psychiatry

-Journal of Child Neurology

-Journal of the Neurological Sciences

-Journal of Neuroinflammation

-Journal of Nuclear Medicine

-J Psychological Research

-Neuroimage

-Neurology

-Neuropediatrics

-Neuroscience

-Pediatric Neurology

-Pediatric Radiology

-Pediatric Research

-Psychiatry Research-Neuroimaging

-Psychological Medicine

-The J Neuropsychiatry & Clinical Neurosciences

-The Lancet (Neurology)


 

 

TEACHING

Years at Wayne State:Three

-Informal classes for residents and medical students

-Supervision and assistance to post-doc fellows and research assistants at PET Center, CHM

Years at other colleges/universities:8 years (at All India Institute of Medical Sciences, India)

-Participated in undergraduate & post-graduate teaching program while pursuing post-graduation &PhD.

 

GRANT SUPPORT

            NIH Research Grant “Identifying Epileptogenic Tubers in TSC” (PI: HT Chugani)

            R01 Period: 7/1/10 – 6/30/15; Total projected award: $ 1,900,000; Role: Co-investigator

 

WORKSHOP & CME ATTENDED:

            -13th International Biophysics Congress, in 1999, in New Delhi, India.

-Regional training workshop on Myocardial Perfusion Scintigraphy using SPECT for Nuclear Medicine Physicians, organized by International Atomic Energy agency in 2000, in New Delhi, India.

-Workshop on Alzheimer’s disease, conducted by All India Institute of Medical Science, in 2001, in New Delhi, India.

-National Symposium on “Statistical & Mathematical Techniques and Radiation Safety in Nuclear Medicine” in 2001, in New Delhi, India.

-Regional training workshop on Radionuclide Treatment of Liver Cancer, organized by International Atomic Energy agency (IAEA), in 2002, in Ho Chi Minh City, Vietnam.

-CME of Society of Nuclear Medicine, in 2002, at Los Angeles, CA, USA.

-CME on Current Perspective in Liver Desease, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.

-Nephrology Update, conducted by All India Institute of Medical Science, in 2002, in New Delhi, India.

-CME on “Radiological Protection of Patients in Use of Ionizing Radiation” and “Management of Radiation Accidents & Emergencies” in 2002 in Lucknow, India.

-International Symposium on Nuclear Oncology, organized by International Atomic Energy agency (IAEA), in 2004, in Porto Alegre, Brazil.

-National Workshop on PET-CT by Indian College of Nuclear Medicine in 2005 in New Delhi, India.

-International Scientific Exchange Program of American Association of Physicists in Medicine in 2006, in New Delhi, India.

-International Symposium on Advances in Diagnostic Medical Physics and Workshop on “Cyclotron-PET-CT” in 2006 in New Delhi, India.

-17th International Cleveland Clinic Epilepsy Symposium in 2007 in Cleveland, Ohio, USA.

-61st Annual Meeting of American Epilepsy Society in 2007 in Philadelphia, USA.

 


 

PUBLICATIONS:

Peer-reviewed publications

I. Report of original work

 

  1. Bal CS, Padhy AK and Kumar A. Clinical features of differentiated thyroid carcinoma in children and adolescents from a sub-Himalayan iodine-deficient endemic zone. Nucl Med Comm, 2001; 22: 881-7.
  2. Bal CS, Kumar A and Pandey RM. A randomized controlled trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyroidism. Thyroid 2002; 12: 399-406.
  3. Bal CS, Padhy AK, Kumar A, Bahadur S. Comparison of Outcomes of Bone Scan, Clinical Judgement and other Imaging Modalities in the Pre-operative Assessment of Mandibular Invasion by Squamous Cell Carcinoma of Oral Cavity. World J Nucl Med 2002; 1:29-34.
  4. Kumar A, Bal CS. Differentiated Thyroid Cancer. Ind J Pediatr 2003; 70:707-713.
  5. Bal CS, Kumar A, Pant GS. Radioiodine lobar ablation as an alternative to completion thyroidectomy in patients with differentiated thyroid cancer. Nucl Med Comm 2003; 24: 120-6.
  6. Bal CS, Kumar A, Chandra P, Dwivedi SN, Mukhopadhyaya S. Is Chest X-ray or High-Resolution Computed Tomography Scan of the Chest Sufficient Investigation to Detect Pulmonary Metastasis in Pediatric Differentiated Thyroid Cancer? Thyroid 2004; 14: 221-229.
  7. Narayana C, Tripathi M, Kumar A, Gowda NK, Phom H, Chandra P, Bandopadhyaya G, Bal C. Technetium-99m-L,L-ethylenedicysteine renal scan as a single-modality investigation for the evaluation of renal morphology and function: a comparative study with technetium-99m-dimercaptosuccinic acid. Nucl Med Commun. 2004 Jul; 25(7):743-747.
  8. Bal CS, Kumar A, Pant GS. Radioiodine dose for remnant ablation in differentiated thyroid carcinoma: a randomized clinical trial in 509 patients. J Clin Endocrinol Metab. 2004 Apr; 89(4):1666-73.
  9. Phom H, Kumar A, Tripathi M, Chandrashekar N, Choudhry VP, Malhotra A, Bal CS. Comparative evaluation of Tc-99m-heat-denatured RBC and Tc-99m-anti-D IgG opsonized RBC spleen planar and SPECT scintigraphy in the detection of accessory spleen in postsplenectomy patients with chronic idiopathic thrombocytopenic purpura. Clin Nucl Med. 2004 Jul; 29(7): 403-9.
  10. Bal C, Kumar A, Tripathi M, Chandrashekar N, Phom H, Murali NR, Chandra P, Pant GS.  High-dose radioiodine treatment for differentiated thyroid carcinoma is not associated with change in female fertility or any genetic risk to the offspring. Int J Radiat Oncol Biol Phys 2005; 63: 449-455.
  11. Bal CS, Kumar A, Chandra P. Effect of Iopanoic Acid (Telepaque) on Radioiodine Therapy of Hyperthyroidism: Long-Term Outcome of a Randomized Controlled Trial. JCEM 2005; 90: 6536-6540.
  12. CS Bal, Ajay Kumar, Prem Chandra, S N Dwivedi, G S Pant. A prospective clinical trial to assess the efficacy of radioiodine ablation as an alternative to completion thyroidectomy in patients with differentiated thyroid cancer undergoing sub-total thyroidectomy. Acta Oncol. 2006;45(8):1067-72.
  13. Ajay Kumar, DN Srivastava, Trinh Thi Minh Chau, Huynh Duc Long, CS Bal, Prem Chandra, Le Truong Chien, Nguyen Van Hoa, S Thulkar, S Sharma, Le Huu Tam, Truong Quang Xuan, Nguyen Xuan Canh, GS Pant, GP Bandopadhyaya. Transarterial Re-188-HDD-Lipiodol in the treatment of Inoperable Hepatocellular Carcinoma: a Prospective Multicenter Clinical Trial. Radiology 2007; 243:509-519.
  14. Prem Chandra S.N. Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey. Utility of imputation analysis in clinical trial on remnant ablation of differentiated thyroid cancer patients. Statistics in Transition-new series 2007; 8 (2): 251-272.
  15. Patricia Bernal, Jean-Luc Raoul, Gaj Vidmar, Erdenechimeg Sereegotov, Felix X. Sundram, Ajay Kumar, Jae Min Jeong, Pawana Pusuwan, Chaitanya Divgi, Pat Zanzonico, Janez Stare, John Buscombe, Chau Trinh Thi Minh, Maung Maung Saw, Shaoliang Chen, Ruben Ogbac, and Ajit K. Padhy. Intra-arterial Rhenium-188 Lipiodol in the treatment of inoperable hepatocellular carcinoma: results of an IAEA-sponsored multi-nation study. IJROBP 2007; 69:1448-55.
  16. Patricia Bernal, Jean-Luc Raoul, Janez Stare, Erdenechimeg Sereegotov, Felix X. Sundram, Ajay Kumar, Jae-Min Jeong, Pawana Pusuwan, Chaitanya Divgi, Pat Zanzonico, Gaj Vidmar, John Buscombe, Trinh Thi Minh Chau, Maung Maung Saw, Shaoliang Chen, Ruben Ogbac, Maurizio Dondi, and Ajit Kumar Padhy. International Atomic Energy Agency-Sponsored Multination Study of Intra-Arterial Rhenium-188-Labeled Lipiodol in the Treatment of Inoperable Hepatocellular Carcinoma: Results with Special Emphasis on Prognostic Value of Dosimetric Study. Semin Nucl Med 2008; 38: S40-S45.
  17. Senthil K.Sundaram, Ajay Kumar, Malek I. Makki, Michael E. Behen, Harry T. Chugani, Diane C. Chugani. Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder. Cereb Cortex 2008; 18:2659-65.
  18. Ajay Kumar, Juhasz C, Asano E, Sundaram SK, Makki MI, Chugani DC, Chugani HT. Diffusion tensor imaging study of the cortical origin and course of the corticospinal tract in healthy children. Am J Neuroradiol 2009;30:1963-70.
  19. Ajay Kumar, Senthil K. Sundaram, Lalitha Sivaswamy, Michael E. Behen, Malek I. Makki, Joel Ager, Harry T. Chugani, Diane C. Chugani. Alterations in Frontal Lobe Tracts and Corpus Callosum in Young Children with Autism Spectrum Disorder. Cereb Cortex 2010;20(9):2103-13.
  20. Ajay Kumar, Otto Muzik, Diane Chugani, Pulak Chakraborty and Harry Chugani. PET-derived biodistribution and dosimetry of the benzodiazepine receptor-binding radioligand (11)C-(R)-PK11195 in children and adults. J Nucl Med 2010;51(1):139-44.
  21. Shamim SA, Kumar R, Halanaik D, Kumar A, Shandal V, Shukla J, Kumar A, Trikha V, Chandra P, Bandopadhayaya G, Malhotra A.Role of rhenium-188 tin colloid radiosynovectomy in patients with inflammatory knee joint conditions refractory to conventional therapy. Nucl Med Commun 2010;31(9):814-20.
  22. Sivaswamy L, Ajay Kumar, Rajan D, Behen M, Muzik O, Chugani D and Chugani HT. A Diffusion Tensor Imaging Study of the Cerebellar Pathways in Children with Autism Spectrum Disorder. J Child Neurol 2010;25(10):1223-31.
  23. Ajay Kumar, Csaba Juhász, Eishi Asano, Sandeep Sood, Otto Muzik, Harry T. Chugani. Objective Detection of Epileptic Foci by 18F-FDG PET in Children Undergoing Epilepsy Surgery. J Nucl Med 2010;51(12):1901-7.
  24. Jeong JW, Sundaram SK, Kumar A, Chugani DC, Chugani HT. Aberrant diffusion and geometric properties in the left arcuate fasciculus of developmentally delayed children: a diffusion tensor imaging study. Am J Neuroradiol 2011;32(2):323-30.
  25. Saporta AS, Kumar A, Govindan RM, Sundaram SK, Chugani HT.Arcuate fasciculus and speech in congenital bilateral perisylvian syndrome. Pediat Neurol 2011 Apr;44(4):270-4.
  26. Jeong JW, Kumar A, Sundaram SK, Chugani HT, Chugani DC. Sharp curvature of frontal lobe white matter pathways in children with autism spectrum disorders: tract-based morphometry analysis. Am J Neuroradiol 2011 Oct;32(9):1600-6.
  27. Harry T Chugani, Ajay Kumar, William Kupsky, Eishi Asano, Sandeep Sood, Csaba Juhasz. Clinical and histopathological correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy. Epilepsia 2011 Sep;52(9):1692-8.
  28. Tiwari VN, Kumar A, Chakraborty PK, Chugani HT. Can Diffusion Tensor Imaging (DTI) Identify Epileptogenic Tubers in Tuberous Sclerosis Complex? Correlation With α-[11C]methyl-L-tryptophan ([11C] AMT) Positron Emission Tomography (PET). J Child Neurol. 2011 Dec 2.
  29. Varun Shandal, Senthil Sundaram, Diane Chugani, Ajay Kumar, Michael Behen, Harry Chugani. Abnormal Brain Protein Synthesis in Language Areas of Children with Pervasive Developmental Disorder: A L-[1-11C]-Leucine PET Study. Journal of Child Neurology 2011 Nov;26(11):1347-54.
  30. Gopal SP, Tiwari VN, Veenstra AL, Kumar A, Behen M, Chugani HT, Sundaram SK. Sensitive Diffusion Tensor Imaging Quantification Method to Identify Language Pathway Abnormalities in Children with Developmental Delay. J Pediatrics 2011 Aug 10. [Epub ahead of print].
  31. Ajay Kumar, Eishi Asano, Senthil K Sundaram, Csaba Juhasz, James Janisse, Diane C Chugani, Sandeep Sood, and Harry T Chugani. Diffusion Tensor Imaging Study of the Origin and Course of Corticospinal Tract. Effect of Epilepsy and Correlation with Cortical Stimulation. (submitted for publication)
  32. Ajay Kumar, Otto Muzik, Pulak Chakraborty, Diane C Chugani, and Harry T Chugani. Brain Distribution, Uptake and Receptor Binding of 11C-[R]-PK11195 in Children and Adults. (submitted for publication)
  33. Vijay Narayan Tiwari, Senthil K.Sundaram, Ajay Kumar, Jeong Won Jeong, Michael E. Behen, Harry T. Chugani, Diane C. Chugani. White matter microstructural integrity pattern in children with Autism Spectrum Disorders with and without cognitive impairment identified with tract based spatial statistics (TBSS). (Manuscript in preparation).
  34. Ajay Kumar, Jeong-Won Jeong, Senthil K. Sundaram, Harry T Chugani, and Diane C. Chugani. Aberrant White Matter Diffusion Property in Young Children with Autism Spectrum Disorder and Developmental Delay. (manuscript in preparation)
  35. Ajay Kumar,Michael Behen, Piti Singsoonsud, Cortney Wolfe-Christensen, Emily Helder, Stacey Halverson, Harry T Chugani. Microstructural Abnormalities in Fronto-temporal Cortical Association Tracts in Children with Histories of Early Severe Deprivation: A Diffusion Tensor Imaging Study. (manuscript in preparation)

 

II. Case reports

 

  1. CS Bal and Ajay kumar. Follicular carcinoma presenting with an isolated scapular metastasis. IJNM 2000; 15(1): 30-32.
  2. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, and Bal CS. Adrenal and Renal Metastases from Follicular Thyroid Cancer. BJR 2005; 78: 1038-1041.
  3. Kumar A,Bal CS, Srivastava DN, Acharya SK, Thulkar S, Sharma S, Duttagupta S. Transarterial Radionuclide Therapy with Re-188-HDD-lipiodol in Case of Unresectable Hepatocellular Carcinoma with Extensive Portal Vein Thrombosis. EJR (extra) 2005; 2005; 56 (2): 55-59.
  4. Kumar A, Bal C, Srivastava DN, Thulkar SP, Sharma S, Acharya SK, Duttagupta S.  Management of multiple intrahepatic recurrences after radiofrequency ablation of hepatocellular carcinoma with rhenium-188-HDD-lipiodol. Eur J Gastroenterol Hepatol 2006;18(2): 219-23.
  5. Kumar A,Srivastava DN, Bal CS. Management of Post-Surgical Recurrence of Hepatocellular Carcinoma with Transarterial Radionuclide Therapy. J Vasc Interv Radiol 2006; 17(1): 157-61.
  6. Ajay Kumar, Harry T. Chugani, Eishi Asano, MD,PhD, Sandeep Sood, Pulak Chakraborty. Epilepsy surgery in a case of encephalitis: use of 11C-PK11195 PET. Ped Neurology 2008;38(6):439-42.
  7. Kumar A, Chugani HT. Niemann-Pick disease type C: unique 2-deoxy-2[¹⁸F] fluoro-D-glucose PET abnormality. Pediatr Neurol. 2011 Jan;44(1):57-60.
  8. Ajay Kumar, Harry T Chugani, Pulak Chakraborty, AHM Mahbubul Huq. Evaluation of Neuroinflammation in X-linked Adrenoleukodystrophy. Pediatr Neurol 2011;44(2):143-6.

 

III. Review articles

 

  1. Bal CS and Ajay Kumar. Radionuclide imaging in Urinary infections. Pediatric Today 2000; 6: 408-410.
  2. Bal CS and Kumar A. Alternative Strategies in the Management of De-Differentiated Thyroid Cancer. Ind J Med Paed Oncol 2005; 26: 28-41.
  3. Bal CS and Kumar A. Radioisotope Therapy for Hepatocellular Carcinoma: Indication, Cost and Efficacy. Trop Gastroenterol 2008;29(2):62-70.
  4. Ajay Kumarand Harry T Chugani. Surgical Treatment of Epilepsy: Update Review. Proceedings of Asian and Oceanian Congress of Clinical Neurophysiology 2009.
  5. Ajay Kumarand Harry T Chugani. PET in the Assessment of Pediatric Brain Development and Developmental Disorders. PET Clinics 2009; 3: 487-515.
  6. Ajay Kumarand Harry T Chugani. Delineating Cortical Networks Underlying Epileptic Encephalopathy and Cognitive Impairment with PET: A Perspective.J Nucl Med. 2011 Jan;52(1):8-9.
  7. Ajay Kumar,Asano and Harry T Chugani. α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies. Biomark Med. 2011 Oct;5(5):577-84.

 

Books and chapters

 

  1. CS Bal and Ajay Kumar. Radionuclide imaging. In Pediatric Nephrology, RN Srivastav and A Bagga (eds), 3rd Edition, Jaypee Brothers, New Delhi, 2001, pp39-49.
  2. CS Bal &A Kumar. Radioisotopes and their applications in Medicine. In Text Book of Biochemistry and Human Biology. GP Talwar and LM Srivastav (eds), Pritice Hall India, New Delhi, 2002, pp1189-1214.
  3. CS Bal and Ajay Kumar. Radionuclide imaging. In R N Srivastava and A Bagga eds. Pediatric Nephrology. New Delhi: Jaypee Brothers, 2004: 45-57.
  4. CS Bal and Ajay Kumar. Nuclear Imaging in vesico-ureteric reflux. In M Bajpai, J P Gearhart, K Hjalmas eds. Progress in pediatric Urology. New Delhi: Penwel publishers plc, 2005: 50-59.
  5. CS Bal and Ajay Kumar. “Role of Radionuclide Investigations in Surgical Practices”. In “Essentials of Surgery”. Sunil Chumbar(ed), Jaypee Brothers, New Delhi, 2005; 336-344.
  6. Prem Chandra, SN Dwivedi, CS Bal, Ajay Kumar, Arvind Pandey, KR Sundaram, Padam Singh. On the use of consort statement in clinical trial on remnant ablation of differentiated thyroid cancer. In Arvind Pandey ed. Biostatistical aspects of health and population. New Delhi: Hindustan publishing corporation (India), 2006: 41-45.
  7. SundaramSK, Ajay Kumar and GP Bandopadhyaya. Radiopharmaceuticals in clinical nuclear medicine. In GS Pant (ed), Basic Physics and Radiation Safety in Nuclear Medicine. Mumbai: Himalaya Publishing House, 2008, chapter 15; pp: 227-240.
  8. Bal CS and Ajay Kumar. Nuclear Imaging in Paediatric Surgery. In D K Gupta (ed), Pediatric Surgery. Jaypee brothers, New Delhi, India, 2008, chapter 12; pp: 140-167.
  9. Sundaram SK and Ajay Kumar. PET Quantification. In GS Pant (ed), Basic Physics and Radiation Safety in Nuclear Medicine. Himalaya Publishing House, Mumbai, India, 2008, chapter 30; pp: 461-474.
  10. CS Bal and Ajay Kumar.Differentiated Thyroid Cancer in Childhood and Adolescence. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, chapter 9; pp 79-95.
  11. CS Bal and Ajay Kumar.Prognostic factors and risk group analyses in patients with differentiated thyroid carcinoma. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, chapter 8; pp 63-78.
  12. CS Bal and Ajay Kumar.Role of Chemotherapy. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, chapter 14; pp 164-170.
  13. CS Bal and Ajay Kumar.Thyroglobulin. In “An International Perspective of Thyroid Cancer: a practical approach to management and related issues”, IAEA, Vienna, chapter 4; pp 26-41.
  14. Ajay Kumarand Harry T Chugani. Imaging approaches to seizure analysis. Functional imaging: PET analysis. In Encyclopedia of Basic Epilepsy Research. Elsevier Ltd, Oxford, UK, chapter 13.
  15.  Ajay Kumar and Harry T Chugani. Application of PET and SPECT in Pediatric Epilepsy Surgery. In Oguz Cataltepe and George Jallo (Eds), Pediatric Epilepsy Surgery: Etiology, Assessment and Surgical Approaches. Thieme publishers, New York, Chapter 10, pp 82-92.
  16. Harry T Chugani andAjay Kumar. Historical perspectives of neuroimaging in epilepsy. In, Harry T Chugani (Ed), Neuroimaging in Epilepsy. Oxford University Press, New York, 2011, chapter 1, pp 3-7.
  17. Ajay Kumarand Harry T Chugani. Functional Imaging: PET. In, Dulac O, Lassonde M, Sarnat HB (Eds), Pediatric Neurology Handbook of Clinical Neurology, 3rd edition. Elsevier (in Press).
  18. Ajay Kumar, Harry T Chugani, F Semah and W Theodore. Epilepsy diagnosis: PET. In, Michael J Aminoff, Francois Boller and Dick F Swaab (Eds), Epilepsies: Part 1: Basic Principles and Diagnoses. The Handbook of Clinical Neurology series, 3rd edition. Elsevier (in press).

 

Published abstracts

 

  1. Bal C S, KumarA, Dwivedi SN. Radioiodine ablation of contralateral normal lobe in low-risk carcinoma thyroid patients following hemithyroidectomy. J Nucl Med 1999; 40: 207
  2. Bal C S, Kumar A, Goswami RK. A prospective randomized control trial to evaluate the adjuvant effect of lithium on radioiodine treatment of hyperthyrpoidism. J Nucl Med 1999; 40: 209
  3. Bal C S, Kumar A, Pant GS. Radioiodine ablation of remaining thyroid lobe/tissue following hemithyroidectomy or subtotal thyroidectomy in low-risk patients with differentiated carcinoma thyroid. Ind J Nucl Med 1999; 14: 112.
  4. Bal C S, A Kumar, Mukhopadhyaya S. detection of X-Ray negative pulmonary metastasis by high resolution CT scan in differentiated thyroid carcinoma and their outcome after radioiodine therapy. Endocrinol Jap 2000; 47: 135.
  5. Gopal V Punjabi, A Kumar, R Goswami, C S Bal. Prevalence of UTI and detection of renal scars by 99mTc DMSA scanning in diabetes Mellitus- A case control study. J Nucl Med 2000;
  6. Bal C S, Kumar A, S Barai, G V Punjabi, A Naik, G P Bandopadhyaya, S Aggarwal, A Malhotra, V S Mehta. Role of 99mTc-GHA brain SPECT in differentiating recurrent glioma from radiation necrosis. EJNM 2000; 27: 997.
  7. Ajay kumar, Pandey R M, Bal C S. A prospective randomized control trial to evaluate the adjuvant effect of Lithium on radioiodine treatment of hyperthyroidism. Endocrinol Jap 2000; 47: 247.
  8. Bal CS, Kumar A, Senthil kumar, G V Punjabi, J B Dasan, Bhatia M, Padma MV, Gaikwad S, Singh VP, Jain S, Gupta S, Sarkar C. Role of Ictal and Interictal Tc99m-HMPAO/ECD SPECT in the evaluation of Surgically remediable epilepsy: Outcome in first 55 operated patients. EJNM 2000; 27: 938.
  9. G V Punjabi, M Mighlani, A Kumar, J B Dasan, P K Dave, C S Bal. Comparison of bone scan and SPECT with structural imaging in diagnosing cause of low backache. EJNM 2000; 27: 920.
  10. Ajay Kumar, Bal C S, Padhy A K. Clinical feature of differentiated thyroid carcinoma in children and adolescents in endemic iodine deficient area. Turk J Nucl Med 2000; 9 (3): 67.
  11. Amite Pankaj, Ajay Kumar, CS Bal et al. Role of three phase bone scintigraphy in the early diagnosis of reflex sympathetic dystrophy of the hand. EJNM 2001; 28: 1167.
  12. Ajay kumar, CS Bal, Abhijit Ghosh et al. Role of GFR and ERPF in predicting renal dysfunction in anaemic patients with normal serum biochemistry. EJNM 2001; 28: 1221-1222.
  13. Gopal V Punjabi, Ajay Kumar, CS Bal. Prognostic value of flow cytometric DNA measurements in Indian Patients with thyroid cancer. EJNM 2001; 28: 1174.
  14. CS Bal, A Kumar and GS Pant. How small should “small dose” of radioiodine be for remnant ablation in differentiated thyroid carcinoma: A prospective randomized clinical trial in 372 patients. JNM 2001; 42: 158.
  15. Chandrashekar N, Ajay Kumar, M tripathi, Hentok Phom, Thomas EJ and CS Bal. Evaluation of L,L-Ethyl cysteine in healthy Indian adults. IJNM 2001; 16: 144.
  16. N Chandrashekar, S Guleria, M Tripathi, Ajay Kumar and CS Bal. Role of Tc-99m L, L-ethyl cysteine in evaluation of renal transplant patients: initial experience. IJNM 2001; 16: 146.
  17. CS Bal, K Gupta, A Kumar, Chandrashekar N, V P Choudhury, R Kashyap, M Mahapatra and A K Padhy. Role of Cr-51-RBC survival studies in the management of hypersplenism. IJNM 2001; 16: 174.
  18. Madhavi T, Chandrashekar N, Thomas EJ, Hentok P, Naveen K, Ajay Kumar, R Kumar, A Malhotra and CS Bal. Hepatobiliary scintigraphy is very crucial in the management of bile leak following laparoscopic cholecystectomy. Nucl Med Comm 2002; 23: 399.
  19. Chandrashekar N, Ajay Kumar, Thomas EJ, Madhavi T, Hentok P, Naveen K, A Malhotra and C S Bal. 99mTc-l,l-ethyl cysteine renal scan as a single modality investigation for the evaluation of renal morphology and function: a comparative study with 99mTc-DMSA renal scan. Nucl Med Comm 2002; 23: 399.
  20. A Kumar, N Keshary, H Phom, N Chandrashekar, E J Thomas, M Tripathi, P S N Menon, K Anand, R M Pandey, C S Bal. A large proportion of children with Down syndrome suffer from thyroid dysfunction. JNM 2002; 43: 330.
  21. A Kumar, H Phom, E J Thomas, N Chandrashekar, M Tripathi, A Malhotra, R Kashyap, V P Choudhry, C S Bal. Detection of accessory spleen following splenectomy in cases of chronic Idiopathic Thrombocytopenic Purpura. JNM 2002; 43: 79-80.
  22. E J Thomas, N Chandrashekar, A Kumar, H Phom, M Tripathi, P K Julka, V P Singh, C S Bal. 99mTc Glucoheptonate Brain SPECT: an Invaluable Tool in the Management of Post-Operative Patients with Primary Brain Tumors Receiving Radiotherapy; Correlative Study with CT, MRI and Clinical Outcome in 140 Patients. JNM 2002; 43: 249.
  23. C S Bal, A Kumar. Can Iopanoic Acid (Telepaque) be used for rapid control of hyperthyroidism prior to 131I therapy: long-term outcome of a randomized control trial. JNM 2002; 43: 125-126.
  24. Tripathi M, Chandrashekar N, Thomas EJ, Naveen K, Ajay Kumar, CS Bal, A Malhotra. Efficacy of F+0 diuresis renography with 99mTc-EC in the evaluation of dilated upper tract in infants & children. EANM-2002; A 2555.
  25. A. Kumar, H.Phom, P. Akshay, N. Chandrashekar, M. Tripathi, E.J.Thomas, M.Srinivas, V. Bhatnagar, C.S. Bal.  Evaluation of cerebral vascular reserve by 99m-Tc-ECD brain Spect: is it a sensitive prognostic parameter in the management of congenital hydrocephalus?  WFNMB 2002; 2568.
  26. A. Kumar, H.Phom, E.J. Thomas, M. Tripathi, N. Chandrashekar, H Zamir, S. Gulati, V.Kalra, C.S. Bal.  Role of 99mTc-ECD brain SPECT in the detection of cerebral perfusion abnormality in cases of attention Deficit Hyperactivity Disorder.  WFNMB 2002; 2573.
  27. A. Kumar, P.Hentok, N. Chandrashekar, E.J. Thomas, M. Tripathi, A. Ghosh, B.L. Jaikhani, O.P. Malhotra, C.S. Bal.  Effect of severe anaemia on renal function: a case-control study.  WFNMB 2002; 2566.
  28. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Differentiated thyroid carcinoma in children and adolescents: clinical features and outcome of radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 4.
  29. Bal CS, Ajay Kumar, G S Pant, A K Padhy. Clinical Characteristics of X-ray negative pulmonary metastasis from differentiated thyroid carcinoma in children and adolescents and their outcome after radioiodine therapy. Ind J Pediatr 2002; SS2: 69: 25.
  30. Thomas EJ, J. Bharathi Dasan, N. Chandrasekhar, M. Tripathi, R. Kumar, A. Kumar, D.K. Gupta, D.K. Mitra, A. Malhotra. Detection of gastroesophageal reflux in survivors of congenital diaphragmatic hernia: A radionuclide scintigraphic study in 26 children. WFNMB 2002: 1; A 320.
  31. Thomas EJ, J. Bharathi Dasan, R. Kumar, N. Chandershekher, M. Tripathi, A. Kumar, S. Menon, S.K. Kabra, A. Malhotra. Silent gastro-esphageal reflux in children presenting with recurrent lower respiratory tract infections. WFNMB 2002: 1; A 321.
  32. Thomas EJ, M. Hadi, M. Tripathi, A. Kumar, J. Bharathi Dasan, N. Chandershekhar, S. Agarwala, C.S. Bal, R. Kumar. Direct radionuclide cystography by suprapublic puncture method – a comparison with micturating cystouretherography in 45 children on follow up for vesico ureteric reflux. WFNMB 2002: 1; A 322.
  33. Y G Rao, Ajay Kumar, G K Pande, P Sahni, T K Chattopadhyay, K Gupta, S Aggarwal, G P Bandopadhyay and C S Bal. Role of 99mTc-DTPA GFR estimation in the evaluation of the effect of preoperative hydration and low dose dopamine infusion on renal function in patients undergoing surgery for obstructive jaundice. BJNM 2003. 6; 62-63.
  34. Ajay Kumar, Srinivasan J V, Phom H, Chandrashekhar N, Tripathi M, C S Bal. Role of bone scan in assessing the fracture healing and predicting the outcome of fracture shaft femur, managed by rimmed intramedullary interlocking. J Nucl Med2003; 44: A 652687.
  35. Ajay Kumar, Pant GS, Padhy AK, Bal CS. Clinical characteristics, treatment, course and outcome of differentiated thyroid cancer in children and adolescents. BJNM 2003. 6; 81-82. 
  36. Ajay Kumar, G S Pant, C S Bal. Clinical characteristics of pulmonary metastasis from differentiated thyroid carcinoma in children and adolescents and their outcome after radioiodine therapy. J Nucl Med 2003; 44(5): 347P.
  37. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K Acharya, K R sundaram and G S Pant. Role of dosimetry in transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma. World congress on Medical Physics and Biomedical Engineering 2003: A 2065.
  38. Ajay Kumar, C S Bal, G P Bandopadhyaya, D N Srivastava, S K Acharya, K R sundaram and G S Pant. Is scatter correction necessary for the dosimetry in transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma? World congress on Medical Physics and Biomedical Engineering 2003: A 2069.
  39. A Kumar, P Chandra, N K Gowda, N Murali, S Choudhury, N Chandrasheker, S Sen, J Bharathidasan, S Aggarwal, G P Bandopadhyaya and C S Bal.Critical evaluation of the role of 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin (TF) in post-surgical follow-up of the patients with differentiated thyroid cancer: a clinical trial. JSNM 2003.
  40. C S Bal, Ajay Kumar, M Tripathi, and G S Pant. High dose radioiodine treatment is not associated with change in fertility or any genetic risk to the offspring. Ind J NuclMed 2003;18 (4): 22-23.
  41. M Tripathi, N Chandrasekhar, N Gowda, A Kumar, C Bal. Effectiveness of Sm-153 therapy in pain palliation from skeletal metastases of carcinoma breast and carcinoma prostate. Ind J NuclMed 2003;18(4): 22.
  42. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant,G P Bandopadhyaya, G K Pandey, S DattaGupta, K R sundaram, Pat Zanzonico, Felix X Sundaram, A K Padhy and C S Bal. Transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma. WJNM 2004; 3: S130-131.
  43. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C S Bal. Trans-hepatic-arterial Re-188 labeled lipiodol therapy (TART) in cases of inoperable hepatocellular carcinoma (IHCC)- a prospective clinical trial. J Nucl Med2004;45(5):147P-148P.
  44. A Kumar, M R Nadig, P Chandra, M Sahoo, G S Pant and C S Bal. Can radioiodine ablation be an effective alternative to completion thyroidectomy in patients undergoing subtotal thyroidectomy (STT) and if yes, what is the optimum 131I administered activity required: a prospective clinical trial. J Nucl Med2004; 45 (5):19P.
  45. N Chandrashekar, M Tripathi, A Kumar, N K Gowda, M R Nadig, C Patel, A Malhotra, S Guleria and C S Bal. Evaluation of 99mTc-L,L-Ethyl Cysteine in renal transplant patients: A comparative study with 99mTc-MAG3 and 131I-OIH. J Nucl Med2004; 45 (5):314P.
  46. Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, K R Sundaram, S Duttagupta, G K Pandey, A Malhotra and C S Bal. Dosimetric and therapeutic evaluation of trans-arterial Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC)-a prospective multicentric clinical trial. 8th AOFNMB 2004; A213.
  47. D N Srivastava, Ajay Kumar, S K Acharya, Sanjay Thulkar, Sanjay Sharma, G K Pandey, S Duttagupta, K R Sundaram, G P Bandopadhyaya, G S Pant, A Malhotra and C S Bal. Trans-arterial radionuclide therapy (TART) in cases of inoperable hepatocellular carcinoma (HCC)- a prospective clinical trial. 6th APCCIR 2004: 324-325.
  48. G Bhaskar, A Kumar, P Chandra, S Gulati, A K Gupta, V Kalra, C S Bal.  Prevalence of gastroesophageal reflux in children with developmental delay: A prospective clinical trial.  J. Nucl Med 2005; 46: 224P.
  49. S Kattimani, A Kumar, R Sagar, C S Bal.  Role of 99mTc-ECD Brain SPECT in the evaluation of patients with catatonia: A prospective clinical Trial.  J Nucl Med 2005; 46: 215P.
  50. CS Bal, T Singhal, K Naveen, M Tripathi, GS Pant, CD Patel, R Kumar, A Kumar, SK Saw, A Malhotra. 18F-FDG PET-CT in 131I WBS negative thyroid cancer: an initial experience. IJNM 2005; 20 (4): 119.
  51. CS Bal, T Singhal, R Kumar, R Verma, P Chandra, A Kumar, GS Pant. Long term outcome of radioiodine lobar ablation in patients with differentiated thyroid cancer. J Nucl Med 2006; 47 (Suppl 1): 324.
  52. A Kumar, C Bal, DN Srivastava, P Chandra, SK Acharya, GS Pant, GP Bandopadhyaya. Dosimetric and therapeutic evaluation of trans-arterial Rhenium-188 in cases of inoperable hepatocellular carcinoma (HCC). J Nucl Med2006; 47 (Suppl 1): 105.
  53. A Kumar, C Bal and DN Srivastava. Modified labeling technique of Rhenium (Re)-188-HDD lipiodol for transarterial radionuclide therapy in liver cancer. J Nucl Med2006; 47 (Suppl 1): 528.
  54. Prem Chandra, CS Bal, SN Dwivedi, Ajay Kumar, Arvind Pandey. An applicability of imputation analysis in clinical trial on remnant ablation in differentiated thyroid cancer. Clinical Trials 2006; 3(1): 208
  55. Ajay Kumar, Senthil K. Sundaram, Diane C. Chugani, Otto Muzik, Michael E. Behen, Fanrong Mu, and Harry T. Chugani. Evaluation of Hippocampal Protein Synthesis in Human Brain Using L-[1-11C]-Leucine PET: Implications for Lateralization of Memory Function. Ind J Nuc Med 2008; 23: 113.
  56. Kumar A, Asano E, Sundaram SK, Juhasz C, Makki M, Janisse J, Chugani DC, Sood S, Chugani HT. Evaluation of the cortical origin of corticospinal tract and its location in the posterior limb of internal capsule in children. Epilepsia 2008; 49 (suppl 7): 407-408.
  57. Senthil Sundaram, Ajay Kumar, Michael Behen, Fanrong Mu, Diane Chugani, Harry Chugani. Decreased protein synthesis in children with idiopathic developmental delay: A C-11 leucine PET study. Ind J Nuc Med 2008; 23: 114.
  58. Ajay Kumar, Senthil K.Sundaram, Lalitha Sivaswamy, Michael E. Behen, Malek I. Makki, Harry T. Chugani and Diane C. Chugani. A DTI study of frontal lobe association tracts, corpus callosum and corticospinal tract in children with autism spectrum disorder. Ann Neurol 2008; 64 (suppl 12): S96-S96.
  59. Otto Muzik, Ajay Kumar, Diane Chugani, Pulak Chakraborty and Harry Chugani. Pediatric radiation dose estimates for the tracer [C-11] PK-11195 based on in vivo PET imaging. J Nucl Med 2008;49 (Suppl 1): 15P.
  60. Ajay Kumar, C Juhasz, E Asano, O Muzik, H Chugani. Objective lateralization and localization of epileptic foci by FDG PET using voxel based analysis in children with intractable epilepsy undergoing surgery. J Nucl Med 2009; 50 (suppl 2): 95P.
  61. Ajay Kumar, H T Chugani, O Muzik, P Chakraborty. [C-11] PK-11195 as a positron emission tomography biomarker of brain inflammation in children with Niemann-Pick disease type-C. J Nucl Med 2009; 50 (suppl 2): 96P.
  62. Ajay Kumar, O Muzik, D Chugani, P Chakraborty and H Chugani. Biodistribution and dosimetry of [C-11] PK-11195 PET imaging in children and adults. J Nucl Med 2009; 50 (suppl 2): 117P.
  63. Behen ME, Ajay Kumar, Helder E, Sinsoongsud P, Halverson S, Thomas K, Chugani HT. Abnormal language and limbic pathways in children with histories of early deprivation:  A diffusion tensor imaging (DTI) study. Ann Neurol 2009; 66 (suppl 13): S99-S99.
  64. Ajay Kumar, Chugani HT, Patterson MC, Muzik O, Chakraborty P. [11-C] PK11195 PET as a biomarker of neuroinflammation in children with NPC. Ann Neurol 2009; 66 (suppl 13); S107-S107.
  65. L Sivaswamy, D Rajan, Ajay Kumar, M Behen, HT Chugani, D Chugani. Study of Cerebellar Pathways in Children with Autism Spectrum Disorder using MRI Diffusion Tensor Imaging (MRI-DTI). Ann Neurol 2009; 66 (suppl 13); S111-S111.
  66. Saporta ASD, Ajay Kumar, Govindan RM, Chugani HT. Arcuate Fasciculus Fiber-tracking Identification and Speech Development in Patients with Congenital Perisylvian Malformations. Ann Neurol 2009; 66 (suppl 13): S116-S117.
  67. Harry T Chugani, Ajay Kumar, William Kupsky, Eishi Asano, Sandeep Sood, Csaba Juhasz. Clinical and histopathological correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy. Epilepsia 2009; 50 (S11): 435-36.
  68. Ajay Kumar, C. Juhasz, E. Asano, O. Muzik and H. T. Chugani. Voxel based analysis of FDG PET images for the presurgical lateralization and localization of epileptic foci in children with intractable epilepsy. Epilepsia 2009; 50 (S11): 429.
  69. L Sivaswamy, A Kumar, O Muzik, M Behen, HT Chugani, DC Chugani. Cerebellar serotonin synthesis capacity in autism spectrum disorders. XIth World Congress of ICNC 2010; Cairo, Egypt.
  70. A Kumar, H Chugani, P Chakraborty, O Muzik. Evaluation of neuroinflammation in children with Niemann Pick disease type-C using [C-11] PK-11195 PET. J Nucl Med 2010; 51 (5): 828.
  71. Anita S. Dias Saporta, Ajay Kumar, Rajkumar M. Govindan, Senthil K. Sundaram, Harry T. Chugani. Arcuate Fasciculus Fiber-Tracking Identification and Speech Development in Patients with Congenital Bilateral Perisylvian Malformations. Neurology 2010; 74 (suppl 2): A489-A489.
  72. Ajay Kumar, Harry T Chugani, Eishi Asano, William Kupsky, Csaba Juhasz, Pulak Chakraborty, Otto Muzik, Sandeep Sood. Role of alpha[11C]methyl-L-tryptophan PET scan in children with intractable epilepsy undergoing epilepsy surgery. J Nucl Med2010; 51 (suppl 2): 137P.
  73. Ajay Kumar, Lalitha Sivaswamy, Mike Behen, Pulak Chakraborty, Otto Muzik, Harry T Chugani, Diane C Chugani. Evaluation of cerebellar serotonin synthesis capacity using alpha[11C]methyl-L-tryptophan (AMT) PET scan in children with autism spectrum disorder. J Nucl Med2010; 51 (suppl 2): 14P.
  74. J-W Jeong, A Kumar, S Sundram, HT Chugani, DC Chugani. Aberrant white matter diffusion property in young children with autism spectrum disorder and developmental delay. RSNA 2010.
  75. J-W Jeong, A Kumar, S Sundram, HT Chugani, DC Chugani. Curvature of frontal lobe white matter pathways in children with autism spectrum disorder. RSNA 2010.
  76. Ajay Kumar, Jeong-Won Jeong, Michael Behen, Lalitha Sivaswamy, Harry T Chugani and Diane C Chugani. Tract Based Spatial Statistical Analysis of White Matter Pathways in Young Children with Autism Spectrum Disorder and Normal MRI. Ann Neurol 2010; 68: S85.
  77. J-W Jeong, S Sundaram, A Kumar, DC Chugani, HT Chugani. Aberrant white matter anisotropy and geometry in left arcuate fasciculus of developmental delayed children. Ann Neurol 2010; 68: S114.
  78. Ajay Kumar, Otto Muzik, Pulak Chakraborty, Diane Chugani, Harry Chugani. Uptake pattern, Tracer Kinetics and Receptor Binding of C-11-[R]-PK11195 in the Brain of Children and Adults. RSNA 2010.
  79. Dhondi D, Khalaf M, Kumar A, Daoud M. Likelihood of Malignancy in Solitary versus Multiple Pulmonary Nodules in Positive FDG PET Scan. ARRS 2011.
  80. O. Muzik, M Khalaf, A Kumar, TJ Mangner. Quantitative assessment of oxidative metabolism in Brown Fat. SNM 2011; 1788.
  81. V Shandal, SK Sundaram, DC Chugani, A Kumar, ME Behen, HT Chugani. Abnormal brain protein synthesis in language areas of children with pervasive developmental disorder: a L-[1-11C]-Leucine PET study. RSNA 2011; 87.
  82. MZ Khalaf, N Jain, A Kumar, A Shields, J Janisse. Role of ultra short-term steroid therapy in characterizing equivocal pulmonary nodules in FDG PET/CT scan. RSNA 2011; 154.
  83. Jeong-Won Jeong, Ajay Kumar, Senthil K. Sundaram, Harry T. Chigani, and Diane C. Chugani. Abnormal diffusivity changes in white matter regions of the children with autism spectrum disorder: comparison of TBSS, TSPOON, and SPM analysis. ISMRM 2011.
  84. Harry T Chugani, Ajay Kumar, Otto Muzik, Pulak K Chakraborty. Basal Ganglia Inflammation in Children with Post-infectious Neuropsychiatric Manifestations: A Positron Emission Tomography Study using [11C]-PK-11195. Ann Neurol 2011; 70 (S15); S168.
  85. Veenstra AL, Behen ME, Wilson BJ, Kumar A, Jeong J-W, Chugani H. Cortical-Striatal Functional Connectivity in Children with Histories of Early Social Deprivation. Ann Neurol 2011; 70 (S15); S170.
  86. Sai Prasad Gopal, Vijay Narayan Tiwari, Amy L. Veenstra, Ajay Kumar, Michael Behen,  Harry T. Chugani, Senthil K. Sundaram. A sensitive diffusion tensor imaging quantification method to identify language pathway abnormalities in developmentally delayed children. Ann Neurol 2011; 70 (S15); S135.
  87. Ajay Kumar, Harry T Chugani, Otto Muzik, Pulak K Chakraborty. Evaluation of Neuroinflammation in Children with Infantile Spasms using [11C]-PK-11195 Positron Emission Tomography. Ann Neurol 2011; 70 (S15); S127.
  88. Vijay Narayan Tiwari, Ajay Kumar, Rajkumar Munian Govindan, Csaba Juhasz, Harry T. Chugani. Correlation between diffusion tensor imaging (DTI) and a-[11C] methyl-L-tryptophan ([11C] AMT) PET in tuberous sclerosis complex. AES 2011.
  89. Jeong JW, Kumar A, Govindan R, Chugani DC, Chugani HT, Chugani DC. "Atypical development of dentatothalamic pathway in children with autistic spectrum disorders ", Proc. Int. Soc. Magnetic Resonance in Medicine, Montréal, 2011.
  90. Jeong JW, Kumar A, Sundaram SK, Chugani DC, Chugani HT, Chugani DC. "Sharp curvature in frontal lobe white matter pathways of children with autism spectrum disorder ", Proc. Int. Soc. Magnetic Resonance in Medicine, Montréal, 2011.

 

INVITED LECTURES/PRESENTATIONS

 

  1. Detection of X-Ray negative pulmonary metastasis by high resolution CT scan in differentiated thyroid carcinoma and their outcome after radioiodine therapy. Part of thiswork was presented in 12th International Thyroid Congress in Kyoto, Japan, from 22-27th Oct 2000. (Bal CS, Kumar A, Mukhopadhyaya S)
  2. A prospective randomized control trial to evaluate the adjuvant effect of Lithium on radioiodine treatment of hyperthyroidism. Part of this work was presented in 12th International Thyroid Congress in Kyoto, Japan, from 22-27th Oct 2000. (Ajay kumar, Pandey RM, Bal CS)
  3. A large proportion of children with Down syndrome suffer from thyroid dysfunction. Part of this work was presented in 49th annual meeting of Society of Nuclear Medicine in LA, CA from June 15-19, 2002. (A Kumar, N Keshary, H Phom, N Chandrashekar, E J Thomas, M Tripathi, P S N Menon, K Anand, R M Pandey, C S Bal)
  4. Detection of accessory spleen following splenectomy in cases of chronic Idiopathic Thrombocytopenic Purpura. Part of this work was presented in 49th annual meeting of Society of Nuclear Medicine in LA, CA from June 15-19, 2002. (A Kumar, H Phom, E J Thomas, N Chandrashekar, M Tripathi, A Malhotra, R Kashyap, V P Choudhry, C S Bal)
  5. Differentiated thyroid carcinoma in children and adolescents: clinical features and outcome of radioiodine therapy. Part of this work was presented in the 2nd International Society of Pediatric Oncology- Asia Conference and 6th National Conference of Pediatric Hematology-Oncology from November 22-24, 2002 in New Delhi, India. (Bal CS, Ajay Kumar, G S Pant, A K Padhy)
  6. Clinical Characteristics of X-ray negative pulmonary metastasis from differentiated thyroid carcinoma in children and adolescents and their outcome after radioiodine therapy. Part of this work was presented in the 2nd International Society of Pediatric Oncology- Asia Conference and 6th National Conference of Pediatric Hematology-Oncology from Nov 22-24, 2002 in New Delhi, India. (Bal CS, A Kumar, GS Pant, AK Padhy)
  7. Role of 99mTc-DTPA GFR estimation in the evaluation of the effect of preoperative hydration and low dose dopamine infusion on renal function in patients undergoing surgery for obstructive jaundice. Part of this work was presented in 2nd Annual Meeting of Asian Regional Cooperative Council for Nuclear Medicine, in Dhaka, Bangladesh, from 6-8th Feb 2003. (Y G Rao, Ajay Kumar, G K Pande, P Sahni, T K Chattopadhyay, K Gupta, S Aggarwal, G P Bandopadhyay and C S Bal)
  8. Clinical characteristics, treatment, course and outcome of differentiated thyroid cancer in children and adolescents. Part of this work was presented in 2nd Annual Meeting of Asian Regional Cooperative Council for Nuclear Medicine, in Dhaka, Bangladesh, from 6-8th Feb 2003. (A Kumar, Pant GS, Padhy AK, Bal CS)
  9. Transarterial Re-188 labeled lipiodol therapy in cases of inoperable hepatocellular carcinoma. Part of this work was presented in International Symposium on Nuclear Oncology, organized by International Atomic Energy Agency, in Porte Allegre, Brazil in Jan, 2004. (Ajay Kumar, D N Srivastava, S K Acharya, G S Pant, G P Bandopadhyaya, G K Pandey, S DattaGupta, K R sundaram, Pat Zanzonico, Felix X Sundaram, A K Padhy and C S Bal)
  10. Trans-arterial radionuclide therapy (TART) in cases of inoperable hepatocellular carcinoma (HCC)- a prospective clinical trial. Part of this work was presented in the 6th Asia Pacific Congress of Cardiovascular and Interventional Radiology in New Delhi, India, from 31st Oct-3rd Nov 2004. (D N Srivastava, Ajay Kumar, S K Acharya, Sanjay Thulkar, Sanjay Sharma, G K Pandey, S Duttagupta, K R Sundaram, G P Bandopadhyaya, G S Pant, A Malhotra and C S Bal)
  11. Evaluation of Hippocampal Protein Synthesis in Human Brain Using L-[1-11C]-Leucine PET: Implications for Lateralization of Memory Function. Part of this work was presented in 9th Congress of Asia Oceania Federation of Nuclear Medicine & Biology, in New Delhi, India, from 31st Oct-4th Nov 2008. (Ajay Kumar, Senthil K. Sundaram, Diane C. Chugani, Otto Muzik, Michael E. Behen, Fanrong Mu, and Harry T. Chugani)
  12. Objective lateralization and localization of epileptic foci by FDG PET using voxel based analysis in children with intractable epilepsy undergoing surgery.  Part of thiswork was presented in the 56th annual meeting of the Society of Nuclear Medicine, in Toronto, Canada, from 13-17 June, 2009. (Ajay Kumar, C Juhasz, E Asano, O Muzik, H Chugani)
  13. [C-11] PK-11195 as a positron emission tomography biomarker of brain inflammation in children with Niemann-Pick disease type-C. Part of this work was presented in the 56th annual meeting of the Society of Nuclear Medicine, in Toronto, Canada, from 13-17 June, 2009. (Ajay Kumar, H T Chugani, O Muzik, P Chakraborty)
  14. Biodistribution and dosimetry of [C-11] PK-11195 PET imaging in children and adults. Part of this work was presented in the 56th annual meeting of the Society of Nuclear Medicine, in Toronto, Canada, from 13-17 June, 2009. (Ajay Kumar, O Muzik, D Chugani, P Chakraborty and H Chugani)
  15. Abnormal language and limbic pathways in children with histories of early deprivation:  A diffusion tensor imaging (DTI) study. Part of this work was presented in the 38th annual meeting of the Child Neurology Society, in Louisville, Kentucky, from 14-17 October, 2009. (ME Behen, Ajay Kumar, E Helder, P Sinsoongsud, S Halverson, K Thomas, HT Chugani)
  16. Study of Cerebellar Pathways in Children with Autism Spectrum Disorder using MRI Diffusion Tensor Imaging (MRI-DTI). Part of thiswork was presented in the 38th annual meeting of the Child Neurology Society, in Louisville, Kentucky, from 14-17 October, 2009. (L Sivaswamy, D Rajan, Ajay Kumar, M Behen, HT Chugani, D Chugani)
  17. Arcuate Fasciculus Fiber-tracking Identification and Speech Development in Patients with Congenital Perisylvian Malformations. Part of this work was presented in the 38th annual meeting of the Child Neurology Society, in Louisville, Kentucky, from 14-17 October, 2009. (ASD Saporta, Ajay Kumar, RM Govindan, HT Chugani)
  18. 11C-PK11195 PET as a biomarker of neuroinflammation in children with NPC. Part of this work was presented in the 38th annual meeting of the Child Neurology Society, in Louisville, Kentucky, from 14-17 October, 2009. (Ajay Kumar, H T Chugani, Mark C Patterson, O Muzik, P Chakraborty)
  19. Delivered a talk on “Diagnosis and Treatment of Pediatric Epilepsy Syndromes” in symposium “INSIDE EPILEPSY”, organized by Atlantic Neuroscience Institute, NJ, USA on May 1 2010.
  20. Evaluation of neuroinflammation in children with Niemann Pick disease type-C using [C-11] PK-11195 PET. Part of this work was presented in the Molecular Neuroimaging Symposium, at NIH, Bethesda, from 6-7May, 2010. (A Kumar, H Chugani, P Chakraborty, O Muzik)
  21. Role of alpha[11C]methyl-L-tryptophan PET scan in children with intractable epilepsy undergoing epilepsy surgery. Part of this work was presented in the 57th annual meeting of the Society of Nuclear Medicine, in Salt Lake City, Utah, from 5-9 June, 2010.(Ajay Kumar, Harry T Chugani, Eishi Asano, William Kupsky, Csaba Juhasz, Pulak Chakraborty, Otto Muzik, Sandeep Sood)
  22. Evaluation of cerebellar serotonin synthesis capacity using alpha[11C]methyl-L-tryptophan (AMT) PET scan in children with autism spectrum disorder. Part of this work was presented in the 57th annual meeting of the Society of Nuclear Medicine, in Salt Lake City, Utah, from 5-9 June, 2010.(Ajay Kumar, Lalitha Sivaswamy, Mike Behen, Pulak Chakraborty, Otto Muzik, Harry T Chugani, Diane C Chugani)
  23. Tract Based Spatial Statistical Analysis of White Matter Pathways in Young Children with Autism Spectrum Disorder and Normal MRI. Part of this work was presented in the 39th annual meeting of the Child Neurology Society, in Providence, RI, from 13-16 October, 2010. (Ajay Kumar, Jeong-Won Jeong, Michael Behen, Lalitha Sivaswamy, Harry T Chugani and Diane C Chugani)
  24. Uptake pattern, Tracer Kinetics and Receptor Binding of C-11-[R]-PK11195 in the Brain of Children and Adults. This work was presented in the 96th annual meeting of the Radiological Society of North America, in Chicago, IL, from 28 Nov-3 Dec, 2010. (Ajay Kumar, O Muzik, P Chakraborty, D Chugani, H Chugani)