School of Medicine

Wayne State University School of Medicine

Dr. Diane Chugani

 

(313) 993-3847 (Voice)
(313) 993-3845 (Fax)
dchugani@pet.wayne.edu

 

Diane Chugani, Ph.D., is currently Professor of Pediatrics and Radiology at Wayne State University. She is the Director of the Translational Imaging Laboratory at Children's Hospital of Michigan. Dr. Chugani obtained a bachelor’s degree in Psychology from the University of Maryland, College Park in 1979. Dr. Chugani obtained her Ph.D. in Pharmacology from the University of California, Los Angeles in 1986, and received postdoctoral training in Biological Chemistry also at UCLA before joining the UCLA faculty in the Departments Pharmacology and Radiology (1988-1993). The aim of Dr. Chugani’s laboratory is to discover mechanisms involved in the pathogenesis of autism and to design and test new treatments based upon the research findings. A combination of approaches is employed and includes imaging studies (PET and MRI), genetic studies and pharmacological studies. Her PET studies of serotonin synthesis in children with autism (funded by NICHD and pilot grants from MIRA and the Pheasant Ring Foundation) identified differences in developmental changes in brain serotonin synthesis in young autistic compared to non-autistic children. Based upon these results, Dr. Chugani conducted a pharmacokinetic, safety and efficacy trial of a serotonergic drug in young autistic children (funded by NICHD through the Pediatric Pharmacology Research Unit network). Based upon the preliminary findings of that study, Dr. Chugani was recently awarded an Autism Center of Excellence Network Grant award (NINDS) to further test this novel treatment for autism. Dr. Chugani is also interested in biochemical mechanisms in epilepsy. In a study of children with tuberous sclerosis complex and medically uncontrolled epilepsy (funded by NINDS and a pilot grant from the National Tuberous Sclerosis Association), Dr. Chugani showed that increased metabolism of tryptophan shown on PET studies in brain regions causing seizures was related to the production of a toxic metabolite of tryptophan metabolism in the kynurenine pathway called quinolinic acid. Dr. Chugani currently holds a grant from NINDS to determine whether this mechanism also occurs in other groups of children with medically uncontrolled epilepsy.

Dr. Chugani is a member of the Scientific Advisory Boards of Autism Speaks and the Tuberous Sclerosis Alliance. She was a founding board member of the International Society for Autism Research. Dr. Chugani was a member of the Brain Disorders and Clinical Neuroscience (BDCN-2) Study Section of the National Institutes of Health for 5 years. She is routinely appointed to NIH special emphasis panels, including reviews of the Conte Centers for Schizophrenia research, the Collaborative Programs for Excellence in Autism, the Brain Disorders members conflict study section, and site reviews of General Clinical Research Centers.

Education
1979 B.A. (cum laude), Psychology
University of Maryland, College Park, MD

1986 Ph.D., Pharmacology
University of California, Los Angeles

Training
1986-1988 Post-doctoral Fellow, Biological Chemistry
University of California, Los Angeles


Faculty Appointments

1988-1992 Assistant Professor
Department of Radiological Sciences
Division of Nuclear Medicine and Biophysics
University of California, Los Angeles

1992-1993 Assistant Professor
Department of Pharmacology
University of California, Los Angeles

10/1/93 - 8/17/98 Assistant Professor
Departments of Pediatrics and Radiology
Wayne State University
Detroit, MI

8/18/98 - 8/21/99 Associate Professor
Departments of Pediatrics and Radiology
Wayne State University
Detroit, MI

8/22/99 – 8/19/04 Associate Professor with tenure
Departments of Pediatrics and Radiology
Wayne State University
Detroit, MI

8/19/04-present Professor with tenure
Departments of Pediatrics and Radiology
Wayne State University
Detroit, MI

11/01-2/07/07 Co-Director, PET Center
Children's Hospital of Michigan

2/07-present Director
Translational Imaging Laboratory
Children’s Hospital of Michigan

Major Professional Societies
Member, Society for Neuroscience
Executive Committee, International Society for Autism Research (2001, 2002)
Member, New York Academy of Science (2003)

Honors/Awards
NIH (NICHD) Mental Retardation Center Trainee Fellowship, UCLA (1986-1988)
Milestone Award from the Mental Illness Research Association (1997)
Ring of Hope Award from the Pheasant Ring Foundation (2001)
Executive Committee, International Society for Autism Research (2001, 2002)

Service
Committee Service:

WSU CTSA Novel Research Initiatives Working Group (2007-present)

Member, Search Committee of Director of the Children’s Research Center of Michigan (2005-2006)

Member, Search Committee for Genomics Core Director (2004)

Member, Search Committee for Pediatric Imaging Chief (2003)

Member, Wayne State University Imaging Research Oversight Committee (2001 to present)

Member, Children’s Research Center of Michigan Research Committee (February 2001 to 2003)

Member, Radioactive Drug Research Committee (RDRC) (1994 to present)

Member, Department of Pediatrics Research Committee (July 1996-December 1998)

Coordinator, Department of Pharmacology Seminar Series, UCLA (1992-1993)

Member, Department of Pharmacology, UCLA, Graduate Curriculum Committee, UCLA (1992-1993)

Member, Department of Pharmacology, UCLA, Graduate Admissions Committee (1992-1993)

Member, Department of Pharmacology, UCLA, Search committee for recruitment of 3 faculty members at Asst. Professor level (1992-1993).

Member, Graduate Program in Neuroscience, UCLA, Admissions Committee (1990-1993).

Member, Department of Biomedical Physics, UCLA, Graduate Admissions Committee, (1989-1992)

Member, Department of Biomedical Physics, UCLA, Graduate Curriculum Committee, (1990-1992)


Scientific Advisory Boards:

Member, Research Council, Epilepsy Foundation of America, July 2006 to present.

Member, Professional Advisory Board, August 1999 to present.
Chair, Scientific Advisory Board, February 2000 to present.
The Sturge-Weber Foundation.

Member, Scientific Advisory Board for Autism Society of America, May 1997 to present.

Member, Scientific Advisory Board for Cure Autism Now, October 1998 to 2007 (CAN merged with Autism Speaks).

Member, Scientific Advisory Board for Autism Speaks, 2007 to present.

Member, Center Without Walls, National Tuberous Sclerosis Association, 1998 to present.

Member, Scientific Adisory Board for the National Tuberous Sclerosis Association, August 1999 to present.

Member, Professional Advisory Board for the Pheasant Ring Foundation, February 2002 to present.

Scientific Meeting Organization
Co-organizer, Sturge-Weber Consensus Conference, June 1999

Program committee for the International Meeting for Autism Research (IMFAR), November 2001, 2003; May 2004

Program committee for International Meeting for IASSID—International Association for the Scientific Study of Intellectual Disability, June 2004

NIH and DOD Grant Review:
Regular member, NIH Brain Disorders and Clinical Neuroscience (BDCN-2) Study Section 1998-2003.

Appointed t o BDCN Member Conflict Special Emphasis Panel, November 2002.

Appointed to Department of Defense review for RFA regarding tuberous sclerosis complex. November 2002, 2003.

Appointed to NIH Special Emphasis Panel to review grants for the Innovative Autism RFA, July 24, 2001.

Appointed to NIH Special Emphasis Panel to review the program project grant "Program for Study of Neuroreceptor Binding in Man" submitted by Johns Hopkins PET Center, June 26-27, 1994.

Appointed to NIH Special Emphasis Panel to review program project grants in response to RFA on Autism. April 1997.

Appointed to NIH Special Emphasis Panel to review program project grant on Dyslexia at Bowman Gray School of Medicine, Wake Forest University, December 1997.

Appointed to ZMH1 BRB P05, NIMH Conte Centers For The Study Of Schizophrenia, March 16-17, 2004

Appointed to Department of Defense review for RFA regarding clinical trials for neurofibromatosis. July 2004.

NIH Site Visits for GCRC grants at Stanford University (November 2005) and UCLA (December 2005)

Ad Hoc Reviewer R13 grants for NIMH (March 2006)


Foundation and International Grant Review:
Review grant proposals for the Sturge-Weber Foundation (2001)
Review grant proposals for the National Tuberous Sclerosis Association (1995, 2002)
Review grant proposals for CAN "Cure Autism Now" (December 1997, January 1999, January 2000, February 2001, January 2002, February 2003, September 2004, September 2005, September 2006)
Reviewer for Medical Research Council of Canada (November 1998)
Reviewer for Thrasher Research Fund (March 2001)
Reviewer for the McKnight Foundation (October 2001, 2003)
Reviewer for the PPP Foundation, UK (April 2003)
Reviewer for the Action Research Foundation, UK (July 2003)
Reviewer for Epilepsy Foundation of America (Novemer 2005)
Review grant proposals for Autism Speaks (May 2007)

Ad hoc reviewer:
Journal of Biological Chemistry
Developmental Brain Research
Journal of Neuroscience Research
Archives of General Psychiatry
Journal Cerebral Blood Flow and Metabolism
Epilepsia
Annals of Neurology
Journal of Nuclear Medicine
Journal of Neuroscience
Journal of the Neurological Sciences
Neurology
Journal of Neurochemistry
NeuroImage
Archives of Neurology
Journal of Neurophysiology
Brain
Biological Psychiatry
Proceedings National Academy of Sciences
International Journal of Neuropsychopharmacology
New England Journal of Medicine
Lancet
Journal of Autism and Developmental Disorders
American Journal of Psychiatry
Synapse
Brain Research

Presented at EXPLORATHON 1995, 1996, and 1997; Program sponsored by Cranbrook and AAUW in which women scientists present their work to high school girls interested in careers in science.

Brain Awareness Week, March 2000, Presentation at West Maple Elementary School, Birmingham School District, Michigan.


Teaching

Member, Executive Committee for newly developed doctoral graduate program, “Translational Neuroscience Program,” May 25, 2006 to present.

Mentor for K12 award for Sujatha Kannan, M.D., Assistant Professor of Pediatrics (Division of Critical Care)

Masters Thesis advisor for:
Jennifer Lee Basic Medical Sciences (2000-2001)
Cynthia Husk Basic Medical Sciences (2000-2001)

Ph.D. Thesis advisor for:
Sreenivasa Chandana Pharmacology (Sept. 2001 – Sept 2004)

Ph.D. rotation student:
Sreenivasa Chandana Pharmacology (Jan. 2001-May 2001)

Supervisor for Postdoctoral Fellows:
Michele Durand, Ph.D. 1988-1989
Hiroshi Shamoto, M.D. 1994-1996
Ednea daSilva, M.D. 1995-1999
Ferenc Nagy, M.D. 1996-1998
Kaku Niimura, M.D. 1996-1999
Csaba Juhasz, M.D. 1998-2001
Eishi Asano, M.D. 1999-2002
Zoltan Pfund, M.D. 1999-2002
Soo Joon Lee, M.D. 1999-2001
Kenji Kagawa, M.D. 2001-2003
Krisztina Benedek, M.D. 2002-2003
Tomomi Kimiwada, M.D. 2003-2004
Bharati Dasan Jadadeesan, M.D. 2003-2004
Thomas Eluvingthal, M.D. 2004-2006
Michael Behen, Ph.D. 2004-2006
Rajkumar Govindan, M.D. 2005-present
Ajay Kumar, M.D. 2006-present
Carlos Batista, M.D. 2006-present

Ph.D. Thesis committee member for:
Kirk Mahoney Biomedical Physics (UCLA)
Lucia M. Notterpek Neuroscience (UCLA)
Sanjay K. Vasu Biological Chemistry (UCLA)
Susanne Koch Cellular and Clinical Neurobiology Program (Wayne State, 1998)
Department of Psychiatry and Behavioral Neurosciences
Sridhar Nimmagadda Cancer Biology, Wayne State (2002-2005)


M.S. Thesis committee member for:
Ian Wilds Basic Medical Sciences (Wayne State, 1999)
Theresa Shaouni Basic Medical Sciences (Wayne State, 2005- 2006)

Undergraduates and Medical Students trained in the laboratory:
Mark Fuster (1989)
Ajit Sarnaik (Summer, 1994)
Jennifer Lee (Summer, 1997; Summer, 1999)
Anita Valanju (Jan. 1998 - 1999)
Eric Slattery (Nov 2002-Sept 2003)

Taught at Wayne State University:

Department of Pediatrics, Faculty/Fellow Lecture: “Pharmacotherapy in autism” April 12, 2006

Department of Pediatrics Grand Rounds, “Autism” April 14, 2006.

WSU Department of Psychiatry and Psychology, Hawthorne Center, Novi, MI invited lecture “Autism”

PYC 7020
1.5 h Lecture entitled "Autism"
December 11, 2001

PYC 7020
1.5 h Lecture entitled "Autism"
February 8, 2000

Bio 7660--Neurobiology 2
4 x 1.5 hour lectures
March 23, 25, 30, April 1, 1999
Brain imaging: PET and MRI

PYC 7020
1.5 h Lecture entitled "Autism"
February 11, 1999

BMB 701
Application of basic biochemistry principals to PET scanning
1 lecture--30 minutes
November 17, 1998

Bio 7660--Neurobiology 2
3 x 1.5 hour lectures
March 26, 1998--Brain imaging: PET
April 2, 1998--Brain imaging: Motor learning
April 7, 1998--Brain imaging: Motor learning

PYC 7020
1.5 h Lecture entitled "Autism"
February 12, 1998

Psychopharmacology course for PGY-II Psychiatry Residents
1 h Lecture entitled "Application of PET to Psychiatry"
March 4, 1998

Didatic course for PGY-II Radiology Residents
1 h Lecture entitled "Clinical and research study of the brain with PET"
March 18, 1998

Neuroscience Survey 719, 2 hours, 50 students, "Neuroimaging"
December 1997, 1996, 1995

February 1996, Gave 2 lectures to Neurology Residents: "Excitatory and Inhibitory Neurotransmitters" and "Antiepileptic Drugs"

September 1994, Gave 3 lectures to Neurology Residents: "Neuronal Differentiation and Migration," "Formation, Structure and Function of Synapses" and "Blood Brain Barrier"

January 1994, Gave 2 lectures to Neurology Residents: "Antiepileptic Drugs: Mechanisms of Action" and "Antiepileptic Drugs: Pharmacokinetics and Drug Interactions"


Taught at UCLA:
Molecular Neurobiology 203M: Fall Quarter 1992, Taught one-half course (15 one hour lectures). This is a graduate course required for all first year Neuroscience graduate students.

Neurochemistry 203M: Fall Quarter 1991, Gave 8 lectures covering blood brain barrier, neurotransmitter synthesis, receptors. This is a graduate course required for all first year Neuroscience graduate students.

Pharmacology 200C: Spring Quarter 1993, Gave 3 lectures covering dopaminergic neurotransmission. This is a graduate course required for all second year pharmacology graduate students.

Developed course "Radiologic Anatomy and Physiology" which is now part of the Biomedical Physics core curriculum.

Fall Quarter 1988 Gave Interactive Teaching Course (IAT) to Freshman Medical Students entitled "Neurological and Psychiatric Disease with Positron Emission Tomography."

Fall Quarter 1989 Gave Interactive Teaching Course (IAT) to Sophomore Medical Students entitled "Positron Emission Tomography."


Grant Support
NIH Grant USHHS 2 P01 NS 15654-11 (Program Project)
"Neuroscience Research with PET"
PI: Micheal E. Phelps
Principal Investigator Subproject III: Diane Chugani
9/1/89 to 8/31/90 $103,281
9/1/90 to 8/31/91 $90,772
9/1/91 to 8/31/92 $94,403

DOE Contract DE-FC03-87ER60615
11/1/89 to 10/31/90 $280,000

Japanese Epilepsy Association Grant
"Functional PET Studies of Television-induced Epilpesy"
3/95 - 2/98 $100,000
PI: Harry T. Chugani
Co-PI: Diane C. Chugani

NIH Grant: R01 NS 34488
"Localization of Epileptic Foci with PET in Children"
Principal Investigator: Harry T. Chugani
Co-Investigator: Diane C. Chugani
Funded for period 12/1/96 to 11/30/99; Total award: $559,279
12/1/96 to 11/30/99 $198,000
12/1/96 to 11/30/99 $179,985
12/1/96 to 11/30/99 $180,525
Funded for period 9/15/00 to 8/31/05; Total award: $1,496,125
9/15/00 to 8/31/01 $277,471
9/01/01 to 8/31/02 $272,916
9/01/02 to 8/31/03 $281,102
9/01/03 to 8/31/04 $289,535
Funded for period 9/1/05 to 8/31/10; Total award $1,948,541

MIRA-Mental Illness Research Association
$30,000 per year for years 1995, 1996, 1997 for PET Studies of Autism
$12,500, July 1997 for "Autism Research Clinic"
awarded to Harry T. Chugani and Diane C. Chugani

Pheasant Ring Community
$12,500 year ongoing commitment beginning July 1997 for "Autism Research Clinic"
awarded to Harry T. Chugani and Diane C. Chugani

Elks CRC for Cerebral Palsy, Principal Investigator: Diane C. Chugani
$5,000 awarded May 1997 for PET studies of Cerebral Palsy

American Association for the Study of Headache
"A positron emission tomography study of serotonin synthesis in patients with migraine headache" PI Seemant Chaturvedi, CoPI Diane Chugani
$20,000 awarded June 1997

National Tuberous Sclerosis Association
"Alpha[C-11]methyl-tryptophan PET in Tuberous Sclerosis Complex"
PI Diane Chugani
2/01/98-1/31/99 $25,254 awarded 12/97

NIH grant 1 R01 HD34942
Brain serotonin synthesis in autism
PI: Diane C. Chugani
Funded for period 12/15/98 to 11/30/01; Total award: $758,181
12/15/98 to 11/30/99 $251,578
12/1/99 to 11/30/00 $245,265
12/1/00 to 11/30/01 $251,641

NIH grant 1R01 NS 38324
Imaging tryptophan metabolism in tuberous sclerosis
PI: Diane C. Chugani
Funded for period 2/1/99 to 1/31/04; Total award: $973,273
2/1/99 to 1/31/00 $194,213
2/1/00 to 1/31/01 $187,170
2/1/01 to 1/31/02 $192,511
2/1/02 to 1/31/03 $197,249
2/1/03 to 1/31/04 $202,130

NIH grant 1 R13 NS38447
Sturge Weber Syndrome Consensus Conference
PI: Harry T. Chugani
Co-PI: Diane C. Chugani
Funded for period 4/01/1999 - 03/31/2000; Total award $45,000

Children’s Research Center of Michigan
Development of software tools for pediatric neuroimaging
PI: Otto Muzik
Co-PI: Diane C. Chugani
Funded for period 1/01/2000 - 12/31/2000; Total award $49,363

NIH grant R01 HD40007-01
Ontogeny of human GABAA receptor complex measured with PET
PI: Otto Muzik
Co-PI: Diane C. Chugani
Funded for period 9-29-00 to 9-28-03, Total award $550,000 direct costs

R21 DA015919-01 (Muzik)
Software tools for pediatric neuroimaging
PI: Otto Muzik
Co-Investigator: Diane C. Chugani
Funded for period 10/01/02-9/30/04 Total award $300,000 direct costs


U01 HD37261-04S2
Pediatric Pharmacology Research Unit
PI: Jacob Aranda
Subproject title: Early pharmacotherapy aimed at neuroplasticity in autism
Subproject PI: Diane C. Chugani
Funded for period 9/30/02 to 12/31/03 Total award $120,000 direct costs

R01 NS 41922
Longitudinal neuroimaging in Sturge-Weber syndrome
PI: Csaba Juhasz
Co-Investigator: Diane C. Chugani
July 1, 2003 to June 30, 2007, Total award $950,000 direct costs

NIH R01 NS 45151
Tryptophan metabolism in children with epilepsy
PI: Diane Chugani
January 1, 2004 to December 31, 2007, Total award $925,000 direct costs

NIH R01 HD 55729
Early pharmacotherapy guided by biomarkers in autism
PI: Diane Chugani
November 1, 2007 to October 31, 2012, Total award $3,855,886 direct costs
(Priority score 121, approved by council)


Publications
I. Original observations in refereed journals

1. Chugani HT, Ackermann RF, Chugani DC and Engel J. (1984) Opioid-induced epileptogenic phenomena: anatomical, behavioral and electroencephalographic features. Ann. Neurol. 15:361-367.

2. Campbell IC, Durcan MJ, Cohen RM, Pickar D, Chugani D and Murphy DL. (1985) Chronic clorgyline and pargyline increase apomorphine-induced stereotypy in the rat. Pharmacol. Biochem. Behav. 23:921-925.

3. Chugani DC, Ackermann RF, and Phelps ME. (1988) In vivo 3-H-spiperone binding: evidence for accumulation in corpus striatum by agonist-mediated receptor internalization. J. Cereb. Blood Flow Metab. 8:291-303.

4. Kedersha NL, Heuser JE, Chugani DC, and Rome LH. (1991) Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. J. Cell Biol. 112:225-235.

5. Chugani DC, Kedersha NL, and Rome LH. (1991) Vault immunofluorescence in the brain: new insights regarding the origin of microglia. J. Neurosci. 11:256-268.

6. Chugani DC, Rome LH, and Kedersha NL. (1993) Evidence that vault organelles localize to the nuclear pore complex, J. Cell Sci. 106:23-33.

7. Chugani HT, da Silva E, Chugani DC: (1996) Infantile spasms: III. Prognostic implications of bitemporal hypometabolism on positron emission tomography. Annals of Neurology, 39: 643-649.

8. Shamoto H, Chugani DC, Chugani HT: (1996) Glucose metabolism in the human cerebellum. 1: Anatomical-functional correlations. Journal of Child Neurology, 11: 451-457.

9. Chakraborty PK, Mangner TJ, Chugani DC, Muzik O, Chugani HT: (1996) A high yield and simplified procedure for the synthesis of a[11C]Methyl-L-Tryptophan. Nuclear Medicine and Biology, 23: 1005-1008.

10. Chugani HT, Muller R-A, Chugani DC: (1996) Functional brain reorganization in children. Brain and Development, 18: 347-356.

11. Muzik O, Chugani DC, Chakraborty PK, Mangner T, Chugani HT: (1997) Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. Journal of Cerebral Blood Flow and Metabolism, 17: 659-669.

12. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, da Silva EA, Chugani HT: (1997) Altered serotonin synthesis in the dentato-thalamo-cortical pathway in autistic boys. Annals of Neurology, 42: 666-669.

13. da Silva EA, Chugani HT, Chugani DC: (1997) Landau-Kleffner syndrome: Metabolic abnormalities in temporal lobe is a common feature. Journal Child Neurology, 12: 489-495.

14. da Silva EA, Chugani DC, Muzik O, Chugani HT: (1997) Identification of frontal epileptic foci in children using positron emission tomography, Epilepsia, 38: 1198-1208.

15. Chugani DC, Muzik O, Chakraborty PK, Mangner T, Chugani HT: (1998) Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan, Synapse, 28: 33-43.

16. Muller RA, Chugani DC, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT: (1998) Impairment of dentato-thalamo-cortical pathway in autistic men: Language activation data from PET. Neuroscience Letters, 245: 1-4.

17. Muzik O, Chugani DC, Shen C, da Silva EA, Shah J, Shah A, Canady A, Watson C, Chugani HT: (1998) An objective method for localization of cortical asymmetries using positron emission tomography to aid in surgical resection of epileptic foci. Computer Aided Surgery, 3: 74-82.

18. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady A, Mangner TJ, Chakraborty PK: (1998) Imaging epileptogenic tubers in children with tuberous sclerosis complex using a[11C]-methyl-L-tryptophan PET. Annals of Neurology, 44: 858-866.

19. Muller RA, Behen ME, Rothermel RD, Chugani DC, Muzik O, Mangner TJ, Chugani HT: (1999) Brain mapping of language and auditory perception in high-functioning autistic adults: a PET study. J Autism Dev. Disorders 29: 19-31.

20. Chugani DC, Muzik O, Behen ME, Rothermel RD, Lee J, Chugani HT: (1999) Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children. Annals of Neurology 45: 287-295.

21. Niimura K, Chugani DC, Muzik O, Chugani HT: (1999) Cerebellar reorganization following cortical injury in humans: effects of lesion size and age. Neurology 52: 792-797.

22. Chugani DC, Sundram BS, Behen M, Lee M-L, Moore GJ: (1999) Evidence of altered energy metabolism in autistic children. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 23: 635-641.

23. Muzik O, Ager J, Janisse J, Shen C, Chugani DC, Chugani HT: (1999) A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children. Progress in Neuro-Psychopharmacol. & Biol. Psychiat. 23: 589-600.

24. Nagy F, Chugani DC, Juhasz C, da Silva EA, Muzik O, Kupsky W, Canady A, Watson C, Shah J, Chugani HT: (1999) Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex. Journal of Cerebral Blood Flow and Metabolism 19: 939-947.

25. da Silva EA, Muller RA, Chugani DC, Shah J, Shah A, Watson C, Chugani HT: Brain activation during intermittent photic stimulation: (1999) A [O-15]water PET study on photosensitive epilepsy. Epilepsia 40(Suppl. 4): 17-22.

26. Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee M-L, Chugani HT: (1999) Increased brain serotonin synthesis in migraine. Neurology 53: 1473-1479.

27. Juhasz C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT: (1999) Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 53: 2037-2044.

28. Niimura K, Muzik O, Chugani DC, Shen C, Chugani HT: (1999) [C-11]Flumazenil PET: activity images versus parametric images for the detection of neocortical epileptic foci. J Nuc Med 40: 1985-1991.

29. Muzik O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, von Stockhausen H-M, Herholz K, Canady A, Gates J, Frost M, Ritter F, Watson C, Chugani HT: (2000) Intracranial EEG versus flumazenil and glucose PET abnormalities in children with extratemporal lobe epilepsy. Neurology 54: 171-179.

30. Asano E, Chugani DC, Muzik O, Shen C, Juhász C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson CE, Chugani HT: (2000) Multimodality imaging for improved detection of epileptogenic lesions tuberous sclerosis complex. Neurology 54:1976-1984.

31. Pfund Z, Chugani DC, Juhasz C, Muzik O, Chugani HT, Wilds IB, Seraji-Bozorgzad N, Moore GJ: (2000) Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and 1H MRS in epilepsy patients. Journal of Cerebral Blood Flow and Metabolism 20: 871-878.

32. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: (2000) Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Annals of Neurology 48: 88-96.

33. Juhasz C, Chugani DC, Muzik O, Watson CE, Shah J, Shah A, Chugani HT: (2000) Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 55: 825-834.

34. Muzik O, Chugani DC, Juhasz C, Shen C, Chugani HT: (2000) Statistical parametric mapping: Assessment of application in children. NeuroImage 12: 538-549.

35. Pfund Z, Chugani HT, Juhasz C, Muzik O, Behen ME, Chugani DC, Nigro MA, Trock GL, Squires LA: (2000) Lissencephaly: Fetal pattern of glucose metabolsm on positron emission tomography? Neurology 55:1683-1688.

36. Chugani DC, Muzik O, Juhasz C, Janisse JJ, Ager J, Chugani HT: (2001) Postnatal maturation of human GABAA receptors measured with positron emission tomography. Annals of Neurology 49: 618-626.

37. Asano E, Kuivaniemi H, Huq M, Tromp G, Behen M, Rothermel R, Herron J, Chugani DC: (2001) A study on novel polymorphisms in the upstream region of vasoactive intestinal polypeptide receptor type 2 gene in autism. J. Child Neurology 16: 357-363.

38. Juhasz C, Chugani DC, Muzik O, Shah A, Shah J, Watson C, Canady A, Chugani HT: Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome. Neurology 2001; 56: 1650-1658.

39. Chugani HT, Behen ME, Muzik O, Nagy F, Juhasz C, Chugani DC: Local brain functional activity following early social deprivation: A study of post-institutionalized Romanian orphans. NeuroImage 2001; 14: 1290-1301.

40. Asano E, Chugani DC, Juhasza C, Muzik O, Chugani HT. Surgical treatment of West syndrome. Brain Dev. 2001; 23: 668-676.

41. Juhasz C, Chugani HT, Muzik O, Chugani DC. Neuroradiological assessment of brain structure and function and its implication in the pathogenesis of West syndrome. Brain Dev. 2001; 23:488-495.

42. Lee JS, Asano E, Muzik O, Chugani DC, Juhasz C, Pfund Z, Philip S, Behen M, Chugani HT: Sturge-Weber Syndrome: Correlation between clinical course and FDG PET findings. Neurology 2001; 57: 189-195.

43. Juhász C, Behen ME, Muzik O, Chugani DC, Chugani HT. Bilateral prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression. Epilepsia 2001; 42:991-1001.

44. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, Mangner TJ, Chakraborty PK, Chugani HT. Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 2001; 57:1269-1277

45. Juhász C, Muzik O, Chugani DC, Shen C, Janisse J, Chugani HT. Prolonged vigabatrin treatment modifies developmental changes of GABAA receptor binding in young children with epilepsy. Epilepsia 2001; 42: 1320-1326.

46. Huq AHM, Chugani DC, Hukku B, Serajee FJ. Evidence of somatic mosaicism in Sturge-Weber syndrome. Neurology 2002; 59: 780-2.

47. Pfund Z, Chugani DC, Muzik O, Juhasz C, Behen ME, Lee J, Chakraborty P, Mangner T, Chugani HT. a[C-11]methyl-L-tryptophan PET in patients with alternating hemiplegia of childhood. J Child Neurol 2002; 17: 253-60.

48. Lee JS, Pfund Z, Juhasz C, Behen ME, Muzik O, Chugani DC, Nigro MA, Chugani HT. Altered regional brain glucose metabolism in Duchenne muscular dystrophy: A PET study. Muscle & Nerve 2002; 26: 506-512.

49. Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner TJ, Chakraborty PK, Sood S, Chugani HT. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology. 2003; 60: 960-968.

50. Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn-Ewing J, Shen C, Gotman J, Chugani HT. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. Epilepsia. 2003; 44:425-34.

51. Chander S, Ergun EL, Chugani HT, Chugani DC, Juhasz C, Shields AF, Weaver DW. High 2-deoxy-2-[18F]fluoro-D-glucose accumulation in a case of retroperitoneal fibrosis following resection of carcinoid tumor. Molecular Imaging and Biology 2002; 4: 363-368.

52. Pfund Z, Kagawa K, Juhasz C, Rubin M, Shen C, Lee JS, Chugani DC, Muzik O, Chugani HT. Quantitative analysis of gray and white matter volumes and glucose metabolism in the Sturge-Weber Syndrome. J Child Neurol 2003;18:119-126.

53. Nabi R, Serajee FJ, Chugani DC, Zhong H, Huq AH. Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. Am J Med Genet. 2004 Feb 15;125B(1):63-8.

54. Juhasz C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner TJ, Chakraborty PK, Sood S, Chugani HT. Evaluation with alpha-[11C]Methyl-l-tryptophan Positron Emission Tomography for Reoperation after Failed Epilepsy Surgery. Epilepsia. 2004 Feb;45(2):124-30.

55. Asano E, Benedek K, Shah A, Juhász C, Shah J, Chugani DC, Muzik O, Sood S, Chugani HT. Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? Epilepsia 2004; 45(9):1091-9.

56. Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Kagawa K, Benedek K, Sood S, Gotman J, Chugani HT. Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures. Clin Neurophysiol. 2004; 115: 2718-2727.

57. Benedek K, Juhász C, Muzik O, Chugani DC, Chugani HT. Metabolic changes of subcortical structures in focal medically intractable epilepsy. Epilepsia 2004;45(9):1100-5.

59. Yu J, Baybis M, Lee A, McKhann G, Chugani D, Kupsky WJ, Aronica E, Crino PB. Differntial gene expression in hemimegalencephaly: activation of Wnt/b-catenin signaling. Epilepsia. 2004 Dec;45(12):1517-24.

60. Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and propagation of epileptic spasms delineated on electrocorticography. Epilepsia. 2005; 46(7):1086-97.

61. Juhasz C, Chugani DC, Muzik O, Wu D, Sloan AE, Barger G, Watson C, Shah AK, Sood S, Ergun EL, Mangner TJ, Chakraborty PK, Kupsky WJ, Chugani HT. In vivo uptake and metabolism of alpha-[(11)C]methyl-L-tryptophan in human brain tumors. J Cereb Blood Flow Metab. 2006 Mar;26(3):345-57.

62. Kagawa K, Chugani DC, Asano E, Juhasz C, Muzik O, Shah A, Shah J, Sood S, Kupsky WJ, Mangner TJ, Chakraborty PK, Chugani HT. Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET). J Child Neurol. 2005 May;20(5):429-38.

63. Maiti DK, Chakraborty PK, Chugani DC, Muzik O, Mangner TJ, Chugani HT. Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635. Appl Radiat Isot. 2005 May;62(5):721-7.

64. Chandana SR, Behen ME, Juhasz C, Muzik O, Rothermel RD, Mangner TJ, Chakraborty PK, Chugani HT, Chugani DC. Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism. Int J Dev Neurosci. 2005 Apr-May;23(2-3):171-82

65. Muzik O, Pourabdollah S, Juhasz C, Chugani DC, Janisse J, Draghici S. Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci. IEEE Trans on Biomed Engineering 2005; 52: 1574-1581.

66. Yu J, Baybis M, Lee A, McKhann G 2nd, Chugani D, Kupsky WJ, Aronica E, Crino PB. Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling. Brain Pathol. 2005 Jul;15(3):179-86.

67. Eluvathingal T, Chugani HT, Behen M, Juhasz C, Muzik O, Chugani DC, Makki M, Maqbool
M. Abnormal Brain Connectivity In Children Following Early Severe Socio-Emotional Deprivation: A Diffusion Tensor Imaging Study. Pediatrics 2006 Jun;117(6):2093-100.

68. Kimiwada T, Juhasz C, Makki M, Muzik O, Chugani DC, Asano E, Chugani HT. Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy. Epilepsia. 2006 Jan;47(1):167-75.

69. Edwards DJ, Chugani DC, Chugani HT, Chehab J, Malian M, Aranda JV. Pharmacokinetics of buspirone in autistic children, J Clin Pharmacol 2006; 46: 508-514.

70. Lin FY, Gascon GG, Hyland K, Chugani H, Chugani D. Transient nonketotic hyperglycinemia and defective serotonin metabolism in a child with neonatal seizures. J Child Neurol. 2006 Oct;21(10):900-3.

71. Eluvathingal TJ, Behen ME, Chugani HT, Janisse J, Bernardi B, Chakraborty P, Juhasz C, Muzik O, Chugani DC. Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates. J Child Neurol. 2006 Oct;21(10):846-51.

72. Sundaram SK, Muzik O, Chugani DC, Mu F, Mangner TJ, Chugani HT. Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue. J Nucl Med. 2006 Nov;47(11):1787-95.

73. Peng F, Juhasz C, Bhambhani K, Wu D, Chugani DC, Chugani HT. Assessment of Progression and Treatment Response of Optic Pathway Glioma with Positron Emission Tomography using alpha-[(11)C]Methyl-L: -Tryptophan. Mol Imaging Biol. 2007; 9(3):106-9.

74. Muzik O, Chugani D, Zhou G, Hua J, Lu Y, Lu S, Asano E, Chugani H. Multimodality Data Integration in Epilepsy, International Journal of Biomedical Imaging (in press).

75. Juhasz C, Batista CEA, Chugani DC, Muzik O, Chugani HT, Evolution of cortical metabolic abnormalities and their clinical correlate in Sturge-Weber Syndrome. Eur J Paediatr Neurol. 2007 Apr 2; [Epub ahead of print]

76. Juhasz C, Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume is a major predictor of cognitive function in Sturge-Weber Syndrome. Archives of Neurology (in press).

77. Juhász C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol 2007 May;28(5):900-6.

78. Makki M, Chugani DC, Janisse JJ, Chugani HT. Abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MRI in tuberous sclerosis complex. American Journal of Neuroradiology (in press).

79. Kannan S, Saadani-Makki F, Muzik O, Chakraborty P, Mangner TJ, Janisse J, Romero R, Chugani DC. Microglial activation in perinatal rabbit brain induced by intrauterine inflammation:
Detection with [11C](R)-PK11195 and microPET. J Nuc Med 2007; May 15; [Epub ahead of print]

II. Review Articles

1. Rome LH, Kedersha NL, Chugani DC. (1991) Unlocking vaults: Organelles in search of a function. Trends Cell Biol. 1:47-50.

2. CAN Conscensus Group (Geschwind D, Cummings JL, Hollander E, DiMauro S, Cook EH, Lombard J, Stefanatos G, Sprouse CA, Jensen P, Mott SH, Zimmerman A, Tuchman RF, Chugani DC, Chez MG, Lewine J, Iversen L, Kornblum H, Griesback A, Miller B, Robinson R, Trauner DA, Nespeca MP, Stubbs GE, Iversen P, Shestack J, Bolte E, Levine H, Levine H, Toedtman M) (1998) Autism screening and diagnostic evaluation: CAN consensus statement. CNS Spectrums. 3: 40-49.

3. Abbott NJ, Chugani DC, Zaharchuk G, Rosen BR, Lo EH: (1999) Delivery of imaging agents to the brain. Advanced Drug Delivery Reviews, 37: 253-277.

4. Mohan KK, Chugani DC, Chugani HT: (1999) Positron emission tomography in pediatric neurology. Semin Pediatr Neurol, 6: 111-119.

5. Chugani HT, Chugani DC: (1999) Basic mechanisms of childhood epilepsies: studies with positron emission tomography. Adv Neurol. 79: 883-891.

6. Chugani DC, Muzik O: (2000) a[C-11]Methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cerebral Blood Flow & Metabolism 20: 2-9.

7. Juhász C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT: Relationship between EEG and positron emission tomography abnormalities in clinical epilepsy. J Clin Neurophysiol 2000;17:29-42.

8. Juhász C, Chugani HT, Muzik O, Chugani DC: Hypotheses from functional neuroimaging studies. . In Schwartzkroin PA, Rho JM (eds.): Epilepsy, Infantile Spasms, and Developmental Encephalopathy. Int. Rev. Neurobiology 2002; 49:37-55.

9. Chugani DC: Role of altered brain serotonin mechanisms in autism. Molecular Psychiatry 2002; 7 Suppl 2:S16-17.

10. Chugani DC, Chugani HT: Does serotonin have trophic effects in temporal lobe epilepsy? Neurology (invited editorial). 2003; 60(5):736-7.

11. Juhasz C, Chugani DC, Chugani HT. Pathophysiology and functional consequences of human partial epilepsy: lessons from positron emission tomography studies. Acta Physiol Hung. 2003;90(4):281-303.

12. Anderson GM, Zimmerman AW, Akshoomoff N, Chugani DC: Autism Clinical Trials: Biological and Medical Issues in Patient Selection and Treatment Response. CNS Spectrums 2004; 9: 57-64.

13. Chugani DC. Serotonin in autism and pediatric epilepsies. Mental Retardation and Developmental Disabilities Research Reviews 2004; 10(2):112-6.

14. Sundaram SK, Chugani HT, Chugani DC. PET Methods with Potential for Increased Understanding of Mental Retardation and Developmental Disabilities, Ment Retard Dev Disabil Res Rev. 2005;11(4):325-30.

15. Chugani DC. Pharmacological Intervention in Autism: Targeting critical periods of brain development. Clinical Neuropsychiatry, 2005, 2(6): 346-353.

16. Chugani HT, Chugani DC. Imaging of serotonin mechanisms in epilepsy. Epilepsy Curr. 2005 Nov-Dec;5(6):201-6.

17. Invited lay review for Cerebrum, an online journal of the Dana Foundation. August 2006. “Bringing the brain of the child with autism back on track. Chugani, DC and Sukel K.

18. Belmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl S, Lajonchere C, Colamarino SA. Offering to Share: How to Put Heads Together in Autism Neuroimaging. J Autism Dev Disord. 2007 Mar 9; [Epub ahead of print]


III. Books and chapters

1. Barrio JR, Keen RE, Chugani DC, Bida G, Satyamurthy N, Phelps ME: (1986) Concepts and techniques used in metabolic tracer studies. In Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry, DM Wieland TJ Mangner and MC Tobes, ed., Springer-Verlag, 213-231.

2. Cummings TJ, Chugani DC, Chugani HT: (1995) Positron emission tomography in pediatric epilepsy. In Adelson PD, Black PM (eds): Surgical management of pediatric epilepsy. Neurosurg Clin North America, 6 (No. 3):465-472.

3. Chugani HT, Kupsky WJ, Chugani DC: (1996) Cortical dysplasia: Surgical treatment and neuropathological findings. In Guerrini R, Andermann F, Canapicchi R, Roger J, Pfanner P (eds.): Dysplasias of cerebral cortex and epilepsy. Lippincott-Raven Pub, Philadelphia, 427-433.

4. Chugani HT, Da Silva E, Chugani DC, Muller R-A: (1998) PET in the diagnostic evaluation of children with focal epilepsy. In I. Tuxhorn, H. Holthausen & H-E Boenigk (eds.) Pediatric Epilepsy Syndromes and their Surgical Treatment. London: John Libbey, 592-606.

5. Muzik O, Chugani DC, Shen C., da Silva E: (1998) Non-invasive imaging of serotonin synthesis rate using PET and [C-11]alpha-methyl-tryptophan in autistic children, in: Quantitative Functional Brain Imaging with Positron Emission Tomography, eds Carson R, Hershkowitz P. Academic Press, San Diego, 201-206.

6. Chugani HT, Chugani DC: (1999) Basic mechanisms of childhood epilepsies: studies with positron emission tomography. in: Jasper’s Basic Mechanisms of the Epilepsies, Third Edition: Advances in Neurology, Vol. 79, eds Delgado-Escueta AV, Wilson WA, Olsen RW and Porter RJ. Lippincott Williams & Wilkins, Philadelphia, 883-891.

7. Juhasz C, Chugani DC, Chugani HT: A PET a normalis agy fejlodesenek esgyermekkori neuropszichiatriai korkepeknek a vizsgalataban. Rudolph C (ed). In: Magyar Tudomany: A Pozitron Emisszios Tomografia (PET) A Vilagban es Magyarorszagon. Oktober/Kulonszam, 1999.

8. Muzik O, Chugani DC, Shen C, Juhász C, von Stockhausen HM, Chugani HT: Assessment of the performance of FDG and FMZ PET imaging against the gold standard of invasive EEG monitoring for the detection of extratemporal lobe epileptic foci in children. In: Physiological Imaging of the Brain with PET, eds. Gjedde A, Hansen SB, Knudsen GM, Paulson OB. Academic Press, San Diego, 2001;381-387.

9. Chugani HT, Chugani DC: (2001) Abnormal development and catastrophic epilepsies: The clinical picture and relation to neuroimaging. In: Brain Plasticity and Epilepsy (International Review of Neurobiology, vol. 45) ed. Engel J Jr., 141-157.

10. Chugani HT, Chugani DC: Ancillary Investigations, Section 2: Studies with Positron Emission Tomography. In: Movement Disorders in Children, editors Fernandez-Alvarez E, Aicardi J. International review of Child Neurology Series, 2001, MacKeith Press, London, pp. 235-249.

11. Shah JR, Chugani DC, Chugani HT: Diagnostic positron emission tomography. (Oxbury J, Polkey C, Duchowny M, eds.) In: Intractable Focal Epilepsy: Medical and Surgical Treatment. W.B. Saunders Co., London 2000; 311-321.

12. Chugani DC: Autism. In The Foundation and Future of Functional Neuroimaging in Child Psychiatry, eds. M. Ernst and J. Rumsey. Cambridge University Press, Cambridge 2000; 171-188.

13. Chugani DC, Chugani HT: New directions in PET neuroimaging for neocortical epilepsy. In Neocortical Epilepsies, eds. Williamson PD, Siegel AM, Roberts DW, Thadani VM, Gazzaniga MS. Adv Neurol 2000; 84: 447-456.

14. Chugani DC, Chugani HT: PET: Mapping of serotonin synthesis. In Functional imaging in the epilepsies, eds. Henry TR, Duncan JS, Berkovic SF. Adv Neurol. 2000; 83:165-71.

15. Chugani HT, Chugani DC: Ancillary Investigations, Section 2: Studies with Positron Emission Tomography. In: Movement Disorders in Children, editors Fernandez-Alvarez E, Aicardi J. International review of Child Neurology Series, 2001, MacKeith Press, London, pp. 235-249

16. Chugani DC, Chugani HT: Positron emission tomography (PET) and single photon emission computed tomography (SPECT) in developmental disorders. In Handbook of Neuropsychology, eds Segalowitz S and Rapin I, Elsevier, 2002, Chapter 8, pp. 195-215.

17. Asano E, Juhasz C, Chugani DC, Muzik O, Chugani HT: Positron emission tomography: Localization for epilepsy surgery. In Reisin RC, Nuwer MR, Hallett M, Medina C (eds.), Advances in Clinical Neurophysiology, Supplements to Clinical Neurophysiology, vol. 54, Elsevier,, 2002, chapter 53, pp. 351-8.

18. Chugani DC. Positron Emission Tomography Studies of Autism. In Bauman M. & Kemper T (eds), Neurobiology of Autism, Johns Hopkins Univ Press, Baltimore (in press).

19. Asano E, Chugani DC, Chugani HT. Positron emission tomography. In Curatolo P (Ed.): Tuberous sclerosis complex: from basic science to clinical phenotypes. International Review of Child Neurology series, Mac Keith Press, London, pp. 124-135, Chapter 8, 2003.

20. Juhász C, Chugani DC, Muzik O, Chugani HT. PET in epilepsy. In: Kuzniecky R & Jackson G (eds.), Magnetic resonance in epilepsy. Academic Press (in press)

 
Published Abstracts (last five years)
Juhasz C, Watson C, Chugani DC, Muzik O, Shah J, Shah A, Chugani HT: Epileptogenicity of “metabolic borderzones” in human neocortical epilepsy. American Academy of Neurology, 2000, accepted for poster presentation, chosen for “Best of the Best” meeting summaryNEUROLOGY 54: (7) A107-A108 Suppl. 3.

Juhasz C, Muzik O, Chugani DC, Rothermel RD, Behen ME, Chugani HT: Ontogeny of human GABAA receptors studied by positron emission tomography. Child Neurology Society 29th Annual Meeting, San Diego (accepted as platform presentation) Annals Neurol. 2000: 48: 517.

Lee JS, Asano E, Juhasz C, Pfund Z, Behen M, Muzik O, Chugani DC, Chugani HT: Sturge-Weber syndrome with unihemisphereic involvement: Correlation between clinical characteristics and FDG PET findings. Child Neurology Society 29th Annual Meeting, Annals Neurol. 2000; 48: 531-532.

Chugani DC, Behen ME, Asano E, Lee J, Rothermel R, Muzik O, Chugani HT: Behavioral subtypes of autistic children show differences in regional brain serotonin synthesis. Soc. Neurosci. Abstracts, 2000; 26: 2103.

Asano E, Chugani DC, Behen M, Rothermel R, Muzik O, Chugani HT: Autism in tuberous sclerosis complex: Evidence for cortical and subcortical mechanisms. Soc. Neurosci. Abstracts, 2000; 26:.

Pfund Z, Chugani DC, Juhasz C, Muzik O, Chugani HT, Wilds IB, Seraji-Bozorgzad N, Moore GJ: (2000) Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and 1H MRS in epilepsy patients. Epilepsia 41(Suppl. 7): 67.

Lee JS, Asano E, Juhasz C, Pfund Z, Muzik O, Chugani DC, Chugani HT: Sturge-Wever Syndrome with unilateral leptomeningeal angioma: Degree and extent of glucose hypometabolism are related to epileptiform pattern. Epilepsia 41 (Suppl. 7): 188.

Asano E, Chugani DC, Juhasz C, Muzik O, Philip S, Shah J, Shah A, Watson C, Canady A, Chugani HT: (2000) Epileptogenic zones in tuberous sclerosis complex: Subdural EEG versus MRI and FDG PET. Epilepsia 41(Suppl. 7): 128.

Juhasz C, Muzik O, Chugani DC, Chugani HT: GABAA receptors in epileptic children: Age-related changes and effect of antiepileptic drugs. Epilepsia 41 (Suppl. 7): 83.

Asano E, Kuivaniemi SH, Huq M, Tromp G, Behen M, Rothermel R, Herron, Chugani DC: Novel polymorphisms in the uptream region of VIPR2 gene have a possible role in gastrointestinal problems and stereotypical behaviors in autism. 50th Annual Meeting of the American Society of Human Genetics, Philadelphia, PA October 3-7, 2000 AM J HUM GENET 67: (4) 169-169 Suppl. 2 OCT 2000

Juhasz C, Chugani DC, Muzik O, Shah A, Shah J, Chugani HT: (2001) Role of alpha[11C]methyl-L-tryptophan PET in localization of epileptic foci in intractable partial epilepsy. Neurology 56(Suppl 3): A265.

Asano E, Husk C, Muzik O, Shen C, Shah A, Shah J, Canady A, Chugani HT, Chugani DC: (2001) Detection of epileptogenic zones in tuberous sclerosis complex using voxel analysis of AMT and FDG PET scanning. American Epilepsy Society Annual Meeting, Philadelphia, December 2001.

Juhasz C, Chugani DC, Muzik O, Asano E, Shah A, Shah J, Canady A, Chugani HT: (2001) Increased cortical uptake of a[11C]methyl-L-tryptophan detected by PET in chidren with intractable epilepsy. American Epilepsy Society Annual Meeting, Philadelphia, December 2001.

Chugani HT, Juhasz C, Chugani DC, Muzik O: (2001) Increased ipsilateral striatal serotonin synthesis following frontal cortical resection in children with epilepsy. American Epilepsy Society Annual Meeting, Philadelphia, December 2001.

Pfund Z, Juhasz C, Chugani DC, Muzik O, Lee JS, Chugani HT: (2001) Sturge-Weber syndrome: quantitative MRI and FDG PET correlations. American Epilepsy Society Annual Meeting, Philadelphia, December 2001.

Juhasz C, Chugani DC, Muzik O, Shah A, Shah J, Chugani HT: (2001) Role of alpha[C-11]methyl-L-tryptophan PET in localization of epileptic foci in intractable partial epilepsy. American Academy of Neurology Annual Meeting, Philadelphia, May 2001.

Pfund Z, Chugani DC, Behen ME, Juhasz C, Muzik O, Lee J, Chugani HT: (2001) Abnormalities of GABAA receptors measured with [C-11]flumazenil PET in autistic children. Society for Neuroscience Annual Meeting, San Diego, November 2001.

Chandana S, Pfund Z, Juhasz C, Muzik O, Behen M, Chugani H, Chugani D: (2001) Re-evaluation of brain glucose metabolic abnormalities in autistic boys. International Meeting for Autism Research, San Diego, November 2001.

Muzik O, Chugani DC, Juhász C, Chugani HT. Effect of chronic vigabatrin treatment on benzodiazepine receptor binding in children with epilepsy. Epilepsia 2001;42(Suppl. 2):125. (24th International Epilepsy Congress, Buenos Aires, Argentina, May 13-18, 2001)

Muzik O, Juhász C, Chugani DC. Chronic vigabatrin treatment modifies developmental changes of GABAA receptor binding in children with epilepsy. J Nucl Med 2001;42(Suppl.):38P. (Annual Meeting of the Society of Nuclear Medicine, Toronto, ON, Canada, June 23-27, 2001)

Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Chugani HT. Decreased GABAA Receptor Binding and Increased Uptake of alpha-[11C]Methyl-L-Tryptophan on PET Can Independently Identify Human Epileptogenic Cortex. American Academy of Neurology Annual Meeting, Denver, CO, May 2002.

Chugani DC, Pfund Z, Chandana S, Behen ME, Muzik O, Juhasz C, Lee J. GABAA receptors measured with [C-11]flumazenil PET in children with autism, Angelman and Landau-Kleffner syndromes. International Meeting for Autism Research, Orlando, Florida, Novermber 2002.

Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn
Ewing J, Shen C, Gotman J, Chugani HT. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):43-44

Huq AHM, Nabi R, Zhong HL, Chugani DC, Serajee FJ.Serotonergic neurotransmission and autism: A genetic analysis. ANN NEUROL 52 (3): S115-S115 Suppl. 1 SEP 2002

Huq AHM, Zhong HL, Nabi R, Chugani DC, Serajee FJ Evidence for an additional susceptibility region for autism on human chromosome 7q36. ANN NEUROL 52 (3): S116-S117 Suppl. 1 SEP 2002

Juhász C, Chugani DC, Asano E, Shah A, Shah J, Muzik O, Sood S, Chugani HT. a[11C]Methyl-L-tryptophan (AMT) PET scanning in 176 patients with intractable epilepsy, Annual Child Neurology Meeting, Oct 2002 Washington DC., Ann Neurol 2002;53 (suppl. 1):S118.

Huq AHMM, Chugani DC, Hukku B, Serajee FJ. Somatic mosaicism in Sturge-Weber syndrome. ANN NEUROL 52 (3): S123-S123 Suppl. 1 SEP 2002

Muzik O, Pourabdollah S, Juhasz C, et al. Objective method for localization of abnormal cortical glucose metabolism using 3D analysis of PET image data. J NUCL MED 43 (5): 825 Suppl. S MAY 2002

Juhasz C, Chugani DC, Muzik O, et al. Decreased GABA(A) receptor binding and increased uptake of alpha-[C-11]methyl-L-tryptophanon PET can independently identify human epileptogenic cortex. NEUROLOGY 58 (7): A150-A150 Suppl. 3 APR 9 2002

Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Sood S, Mangner T, Chakraborty PK, Chugani HT. a[11C]Methyl-L-tryptophan (AMT) PET can detect residual epileptic cortex following failed cortical resection in children with intractable epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):126-127.

Chugani HT, Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK. Surgery for intractable infantile spasms: the role of a[11C]Methyl-L-tryptophan (AMT) PET scanning. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):75-76.

Kagawa K, Juhasz C, Chugani DC, Muzik O, Chugani HT. Maximal reduction of N-acetylaspartate in metabolic border zone of fluorodeoxyglucose-positron emission tomography in nonlesional extratemporal lobe epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):76.

Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Shah J, Sood S, Kagawa K, Benedek K, Chugani HT. Cortical GABAA receptor-binding abnormalities remote from the primary epileptic focus: what are their electrophysiologic and clinical significance? Epilepsia 2003; 44 (Suppl 9):311-312. (Poster presentation; Annual Meeting of the American Epilepsy Society, Boston, MA, December 5-10, 2003)

Chugani HT, Juhász C, Behen M, Ondersma R, Muzik O, Chugani DC. Autism with facial port-wine stain: a new syndrome? Ann Neurol 2003;54 (suppl 7):S129 (Poster presentation; Annual Meeting of the Child Neurology Society, October 2003, Miami, FL)

Muzik O, Kagawa K, Juhász C, Chugani HT, Chugani DC. Pattern of GABA-A receptor distribution in children with epilepsy. Epilepsia 2003;44(Suppl.8):183-184. (Poster presentation;25th International Epilepsy Congress, Lisbon, Portugal, 12-16 October, 2003)

Asano E, Benedek K, Shah A, Juhász C, Muzik O, Chugani DC, Sood S, Chugani HT. Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? Epilepsia 2003; 44 (Suppl 9):163-164. (Platform presentation; Annual Meeting of the American Epilepsy Society, Boston, MA, December 5-10, 2003)

Juhász C, Chugani DC, Muzik O, Sloan A, Barger G, Watson C, Sood S, Chugani HT. PET imaging of recurrent brain tumors using a_[11C]methyl-L-tryptophan. Accepted for presentation at the Annual Meeting of the American Academy of neurology, April 29, 2004, San Francisco, CA

Muzik O, Pourabdollah S, Juhasz C, Chugani DC, Draghici S, Chugani HT. Quantitative assessment of the spatial relationship between electrophysiological and functional data in the cortex of epileptic children. J Nuc Med 2003; 44 (5) (Suppl): 13P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

Muzik O, Kagawa K, Juhasz C, Chugani HT, Chugani DC. Non-invasive imaging of the GABA-A receptor complex in children with epilepsy using PET. J Nuc Med 2003; 44 (5) (Suppl): 245P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

Muzik O, Pourabdollah S, Juhasz C, Chugani DC, Draghici S, Chugani HT. Application of an objective method for localizing bilateral cortical abnormalities to guide the resection of epileptic foci. Brain 2003; 23 (suppl 6): S659 (Poster presentation; BrainPET '03, Calgary, Canada 29 June 29 - 3 July, 2003)

Maiti D, Chakraborty PK, Chugani DC, Muzik O, Mangner T, Chugani HT. An improved synthesis procedure for routine production of [Carbonyl-11C] desmethyl-way-100635. J Labeled Compounds and Radiopharmaceuticals 2003; 46 (8) (suppl 1): S233. (Poster presentation, 15th International Symposium on Radiopharmaceutical Chemistry, Sydney, Australia, 10-14 August 2003).

Jagadeesan BD, Behen M, Makki M, Muzik O, Juhasz C, Chugani DC, Chugani HT Abnormal brain connectivity in children with early severe social deprivation: Diffusion tensor imaging study. Ann Neurol 56: S91-S91 Suppl. 8, 2004

Kagawa K, Chugani DC, Behen M, Chandana SR, Juhasz C, Muzik O, Chugani HT Altered brain growth in children with tuberous sclerosis complex and autism. Ann Neurol 56: S93-S94 Suppl. 8, 2004

Chandana SR, Behen ME, Rothermel R, Juhasz C, Muzik O, Chugani HT, Chugani DC. Serotonergic abnormalities in caudate nucleus in autism. Ann Neurol 56: S94-S94 Suppl. 8, 2004

Behen ME, Solomon K, Phan KL, Makki M, Fitzgerald DA, Muzik O, Juhasz C, Jagadeesan BD, Chugani DC, Chugani HT. Brain activation during emotional face recognition in children with early social deprivation. Ann Neurol 56: S94-S94 Suppl. 8, 2004

Behen ME, Chandana SR, Rothmel R, Muzik O, Juhasz C, Chugani HT, Chugani DC. Lateralized cortical serotonergic abnormalities in autistic children are associated with social subtypes. Ann Neurol 56: S95-S95 Suppl. 8, 2004

Maiti DK, Chakraborty PK, Mangner TJ, Chugani DC, Chugani HT. Role of tertiary amine in the condensation reaction of C-11-DWAY and C-11-way synthesis. Abstr Am Chem 227: U54-U55 261-MEDI Part 2, MAR 28 2004

Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Shah J, Sood S, Chugani HT. Flumazenil PET in children with intractable partial epilepsy or infantile spasms: does it provide additional localizing information? Epilepsia 2004;45(suppl 7):366. (Platform presentation at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004.)

Asano E, Juhász C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Analysis of intracranial electrocorticography in children with epileptic spasms. Epilepsia 2004;45(suppl 7):249. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004.)

Kimiwada T, Juhász C, Makki M, Jagadeesan BD, Muzik O, Chugani DC, Chugani HT. Thalamic and hippocamnpal diffusion tensor imaging (DTI) abnormalities in children with temporal lobe epilepsy. Epilepsia 2004;45(suppl 7):295. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004.)

Eluvathingal T, Juhász C, Chugani DC, Kagawa K, Muzik O, Shah A, Asano E, Sood S, Chugani HT. a-[11C]Methyl-L-tryptophan (AMT) PET can localize epileptogenic tubers when scalp EEG is poorly localizing in children with tuberous sclerosis. Epilepsia 2004;45(suppl 7):296-7. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004.)

Juhasz C, Chugani DC, Chugani HT. Longitudinal changes of brain glucose metabolism in children with Sturge-Weber syndrome and epilepsy. Epilepsia 2005; 46(Suppl 8): 50-51.

Asano E, Rothermel R, Behen M, Muzik O, Chugani DC, Pawlak C, Janisse J, Ager J, Chugani HT. Occipital alpha peak frequency during quiet wakefulness is an independent predictor of cognitive function in children with focal epilepsy. Epilepsia 2005; 46( Suppl. 8):
140-141.

Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Sood S, Chugani HT. Quantitative analysis of ictal electrocorticography in children with tuberous sclerosis complex.
(Suppl. 8): 313.

Wakamoto H, Eluvathingal T, Makki M, Behen ME, Juhasz C, Muzik O, Senthil S, Chugani DC, Chugani HT. Diffusion tensor imaging of the corticospinal tracts after cerebral Hemispherectomy. Annals of Neurology 2005; 58 (Suppl. 9): 94.

Eluvathingal TJ, Behen ME, Makki M, Juhasz C, Muzik O, Chugani DC, Chugani HT. Abnormal language network is associated with language dysfunction in children subjected to early social deprivation: A diffusion tensor imaging study. Annals of Neurology 2005; 58(Suppl. 9):94-95.

Behen ME, Eluvathingal TJ, Bernardi B, Janisse J, Juhasz C, Muzik O, Chugani DC, Chugani HT. Cerebellar lesions in patients with tuberous sclerosis complex: Neuroimaging and neurobehavioral findings. Annals of Neurology 2005; 58 (Suppl. 9): 95.

Behen ME, Rothermel R, Geenen E, Eluvathingal T, Chugani DC, Chugani HT. Incidence of specific neurocognitive impairment in a sample of children with history of early severe social deprivation. Annals of Neurology 2005; 58 (Suppl. 9): 128.

Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and propagation of epileptic spasms delineated on electrocorticography. Epilepsia 2005; 46(7): 1086-1097.

Sundaram S, Chugani D, Munian Govindan R, Asano E, Juhász C, Chakraborty P, Muzik O, Sood S, Chugani HT. Alpha-methyl-L-tryptophan positron emission tomography (AMT-PET) predicts surgical outcome in children with intractable neocortical epilepsy. Ann Neurol 2006;60(suppl 3): S137. Presented at the Annual Meeting of the Child Neurology Society, Pittsburgh, PA, October 2006.

Behen ME, Juhász C, Helder E, Batista CEA, Chugani DC, Chugani HT. Cognitive function in Sturge-Weber syndrome: Efect of side and extent of severe hypometabolism on PET scanning. Ann Neurol 2006;60(suppl 3): S122. Presented the Annual Meeting of the Child Neurology Society, Pittsburgh, PA, October 2006.

Muzik O, Sundaram S, Chugani DC, Mu F, Mangner TJ, Chugani HT. Determination of an index of protein synthesis (IPS) in brain using 1-[11C]-leucine PET: Effect of large neutral amino acid plasma levels and recycled tissue amino acids. J Nucl Med 2006; 47(1): 12P

Chakraborty PK, Maiti DK, Mangner TJ, Chugani DC, Chugani HT. High yield and semi-automated synthesis procedure of (R)-[11C]PK11195. J Nuclear Med 2006; 47:522P.

Sivaswamy L, Kumar R, Juhász C, Maqbool M, Chugani DC, Makki M, Chugani HT. DTI tractography detects abnormal corticospinal tract in children with Sturge-Weber syndrome and absence of severe motor deficit. Ann Neurol 2006; 60 (Suppl. 3):S125-6. Presented at the 35th Annual Meeting of the Child Neurology Society, Oct 18-21, 2006, Pittsburgh, PA.

Juhász C, Haacke M, Hu J, Xuan Y, Muzik O, Chugani DC, Chugani HT. Susceptibility weighted imaging in Sturge-Weber syndrome: relation to cortical hypometabolism and seizures. Presented at the Annual Meeting of the American Epilepsy Society, Dec 1-5, 2006, San Diego, CA.

Govindan RM, Sundaram SK, Muzik O, Chakraborty PK, Chugani HT, Chugani DC. Kinetic analysis of alpha-[11C]methyl-L-tryptophan (AMT) abnormalities in PET studies of children with intractable epilepsy. Presented at the Annual Meeting of the American Epilepsy Society, Dec 1-5, 2006, San Diego, CA.

Wakamoto H, Chugani DC, Juhász C, Muzik O, Chugani HT. Alpha-[11C]methyl-L-tryptophan uptake on PET in intractable childhood epilepsy with cortical developmental malformations. Presented at the Annual Meeting of the American Epilepsy Society, Dec 1-5, 2006, San Diego, CA.

Williams MT, Eluvathingal TJ, Behen ME, Chugani DC, Chugani HT. Abnormal asymmetry in the arcuate fasciculus of autistic children: A DTI study. International Meeting for Autism Research, Montreal, Canada, June 1-3, 2006.

Rothermel RR, Behen ME, Geenen E, Fish A, Chugani HT, Chugani DC. Pilot efficacy of treatment with buspirone in autistic children: A randomized double blind study in children 2 to 6 years of age. International Meeting for Autism Research, Montreal, Canada, June 1-3, 2006.

Behen ME, Rothermel RR, Geenen E, Stano C, Chugani DC. Sensory problems in autism: Incidence, symptom patterns and correlates. International Meeting for Autism Research, Montreal, Canada, June 1-3, 2006.

Kannan S, Sadaani-Makki F, Chugani D, Muzik O, Skoff R, Romero R. PET imaging of intrauterine inflammation induced perinatal brain injury. Soc. for Neuroscience Atlanta, GA October 14-18, 2006.


Presentations
1. Invited and/or refereed international or national meetings

Chugani DC, Ackermann RF, Phelps ME (1985) In vivo spiperone binding is altered by dopaminergic pathway stimulation. Presented at Society for Nuclear Medicine. J Nuc Med 26: 52.

Chugani DC, Ackermann RF, Phelps ME (1987) In vivo receptor binding: the role of receptor-mediated endocytosis. Presented at 13th Int. Symp. Cereb. Blood Flow Metab., Montreal, J Cereb Blood Flow Metab 7(Suppl. 1): S342.

Chugani DC, Chugani HT, Mangner TJ, Muzik O, Chakraborty PK: Localization of epileptic foci with [11-C]flumazenil PET in children. Presented at the XVII International Symposium on Cerebral Blood Flow and Metabolism, Cologne, Germany, July 2-6, 1995. Published in J Cereb Blood Flow Metab 1995;15(Suppl 1):179.

Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT: Brain serotonin synthesis rate measured with [C-11]amethyl-tryptophan positron emission tomography in normal and autistic subjects. Child Neurology Society Annual Meeting, 1996. Platform presentation.

Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT: Brain serotonin synthesis measured with a[C-11]-methyl-tryptophan positron emission tomography in normal and autistic adults. Society for Neuroscience Annual Meeting, 1996. Platform presentation.

Third International Symposium on Basic Mechanisms of the Epilepsies: Cellular and Molecular Approaches, [C-11]Flumazenil PET in children with intractable epilepsy. San Diego, CA, April 1996.

Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty PK, Mangner TJ, Chugani HC: [C-11]amethyl-tryptophan PET demonstrates increased brain serotonin synthesis rate in autistic adults. IASSID, July 1996. Platform presentation.

Think Tank on Neurology of Autism sponsored by CAN "Cure Autism Now" Group, March 8-9, 1997, "Altered brain serotonin synthesis in autism measured with PET."

International Symposium on Alternating Hemiplegia, May 16-17, 1997, Seattle, Washington, "Can altered tryptophan metabolism mimick respiratory chain mitochondrial encephalomyopathy?"

Chugani DC, Chugani HT, Niimura K, Muzik O: Differences in brain serotonin synthesis capacity during development in autistic and non-autistic children. Child Neurology Society 26th Annual Meeting, Oct 1997, Accepted for platform presentation.

Chugani DC, Chugani HT, Niimura K, Muzik O: Developmental differences in brain serotonin synthesis capacity in autistic and non-autistic children. Society for Neuroscience Annual Meeting, 1997. Accepted for platform presentation.

"Cure Autism Now" Parent and Professional Conference, October 18, 1997, New York, NY. "Alterations of serotonin synthesis in autism."

Invited panelist: Approaches to developmental and learing disorders in infants and children: Theory and practice 1997, Rockville, MD, November 1997

Invited speaker at "Workshop to explore the implications of brain research for improving early childhood" sponsored by the New Jersey State Department of Education and Education Commission of the States. "Are there implications from brain research developments for improving early childhood?" Trenton, NJ; March 5, 1998

Invited conference speaker at the Gatlinburg Conference on Research and Theory in Mental Retardation and Developmental Disabilities. "PET technologies in Mental Retardation/Developmental Disabilities Research", Charleston, South Carolina; March 11, 1998

Invited to participate in "Animal model of autism workshop" sponsored by Cure Autism Now Foundation, Los Angeles, CA, March 15, 1998

Invited conference participant at Tuberous Sclerosis Complex Consensus Conference sponsored by NINDS and NICHD., Annapolis, MD, July 10-11, 1998

Chugani DC, Heyes MP, Kuhn DM, Chugani HT: Evidence a[C-11]methyl-L-tryptophan PET traces tryptophan metabolism via the kynurenine pathway in tuberous sclerosis complex. Society for Neurscience Annual Meeting, 1998, Los Angeles, CA. Platform presentation.

Invited speaker at the National Family Conference on Tuberous Sclerosis; July 22-25, 1999; “Behavior concerns and autism and PDD: Treatment and current research.”

Invited speaker at the Neurobiology of Autism, International School of the Neurological Sciences, 9th Annual Symposium of the Child Neurology Section, Rome, Italy, June 25-26, 1999.

Invited speaker at Autism Conference entitled “Autismo: Ricerca scientifica e impegno della societa” in Catania, Sicily, June 27, 1999.

Invited speaker at the annual meeting of the British Association for Psychopharmacology, Symposium in Harrogate, England, July 28, 1999 “Towards Understanding Autism”, talk entitled “The Neurochemistry of Autism.”

Invited speaker at “International Conference on Autism and Disorders of Relating and Communicating”, in McLean, Virginia, November 13, 1999, “Altered serotonin synthesis capacity in autism.”

Invited speaker (could not attend due to family illness) at “Behavioural Disorders in Tuberous Sclerosis: Concepts and Current Research” in Cambridge, England January 14-16, 2000, “Functional Imaging in Autistic Spectrum Disorder in Tuberous Sclerosis Complex”.

Invited speaker at the National Tuberous Sclerosis Center Without Wall Meeting, Boston, Mass., March 24, 2000, “Epilepsy and Autism in Tuberous Sclerosis Complex.”

Invited speaker at the Second Hershey Conference on Developmental Cerebral Blood Flow and Metabolism, Hershey Pennsylvania, June 8-11, 2000, “Ontogeny of Human GABAA Receptor Binding Studied with PET.”

Invited speaker at the Sturge-Weber Foundation Family Conference, Atlanta, Georgia, June 23, 2000, June 23, 2000.

Chugani DC, Behen ME, Asano E, Lee J, Rothermel R, Muzik O, Chugani HT: Behavioral subtypes of autistic children show differences in regional brain serotonin synthesis. Soc. Neurosci. Abstracts, 2000, platform presentation.

Invited speaker at conference entitled “New Biological Directions in Autism,” Orlando, FL, October 14, 2000, “Neuroimaging techniques in Autism.”

Invited speaker at conference entitled “6th Annual Conference: Current trends in Autism,” Danvers, MA, October 20, 2000, “Functional imaging in Autism.”

Invited speaker at “Microbiology, Immunology and Toxicology of Autism and Other Neurodevelopmetal Disorders,” Banbury Center, Cold Spring Harbor Laboratory, February 11-14, 2001.

Invited speaker at “Tuberous Sclerosis Behavioral Meeting,” Cincinnati, OH, March 23-25, 2001, “AMT-PET in the evaluation of autism in Tuberous Sclerosis Complex.”

Invited speaker at Yonsei University School of Medicine, Seoul, Korea, June 19, 2001, "Functional imaging studies in autism."

Invited speaker at the Sturge-Weber Foundation Family Conference, Schaumburg, IL. June 28-July1, 2001, “Update on Research Funded by The Sturge-Weber Foundation.”

Invited speaker at “Potential Cellular and Molecular Mechanisms in Autism and Related Disorders” Sponsored by NICHD and NIEHS, Co-sponsored by NIMH, NINDS, and NIDCD
September 6-7, 2001, “Abnormal serotonin (5-HT) synthesis in autistic brain.”

Invited speaker at Children's Mercy Hospital, Kansas City, MO, December 7, 2001, "Functional imaging in children with autism: Results point to strategies for pharmacological intervention."

Invited speaker at “Autism Clinical Trials Task Force” sponsored by Cure Autism Now, Santa Monica California, April 12-14, 2002.

Invited speaker at International Assoc. for the Scientific Study of Intellectual Disability Conference, University College Dublin, June 12-15, 2002.

Invited speaker at Satellite Symposium of the Joint Congress of ICNA and AOCNA, Hong Kong Sept. 18-19, 2002 entitled "Autism/Neuromuscular Disorders".

Invited speaker at American College of Neuropsychopharmacology, San Juan Puerto Rico, December 8-12, 2002, Study group on "Autism: New views from brain imaging."

Invited speaker at “2003 Tuberous Sclerosis Complex Brain/Behaviour Workshop,” Cambridge, England, January 10-12, 2003, “PET/MRI studies”.

Invited speaker at Post graduate course entitled “Autism and pervasive developmental disorders”, Assisi, Italy, March 19-21, 2003.

Invited panelist, NINDS Imaging Markers of Epileptogenesis: New Research Directions, Washington, DC, April 10-11, 2003.

Invited speaker, New York Academy of Sciences “Functional Imaging and Neuropathology of Autism,” New York, NY, May 20, 2003.

Invited lecturer, National Institute for Child and Family Development, Mahidol University, Bangkok, Thailand, July 21, 2003.

Invited speaker, 9th Annual Conference of the Autism Research Foundation, “Current Trends in Autism”, Newton MA, October 24, 2003.

Invited speaker, 7th International Conference of the Interdisciplinary Council on Developmental and Learning Disorders “Autism and Disorders of Relating and Communicating”, Tysons Corner, VA, November 8, 2003.

Invited speaker, UC Davis Epilepsy and Autism Conference, “Serotonin and GABA in autism and pediatric epilepsies,” Sacramento, CA, March 26-28, 2004

Invited speaker, Dutch EndoNeuroPsycho Meeting, “Neurochemical characteristics of epileptogenic lesions: PET experience,” Amsterdam, Netherlands, June 3-4, 2004.

Invited speaker, Universite Paris, Hopital Robert-Debre, “Pathophysiology of autistic syndromes,” Paris, France, June 23, 2004.

Invited speaker, National Alliance for Autism Research Workshop “Integrating the Clinical and Basic Sciences of Autism,” presentation entitled Brain serotonin synthesis: Role in genetic and pharmacology studies. Fort Lauderdale, Florida, November 12-13, 2004.

Invited keynote speaker, Learning & the Brain Conference, presentation entitled “The Adaptability of the Developing Brain: Plasticity, Experiences, Critical Learning Periods and Autism in Children and Adolescents,” Boston, MA, April 28, 2005.

Invited panelist, Cure Autism Now Imaging Summit, Los Angeles, CA January 22-24, 2006.

Visiting professor, Illinois Autism Colloquium, DeKalb, Illinois April 6-7, 2006.

Co-Chair, Biochemical Biomarkers Group, NIH Workshop on “Biomarkers of Epileptogenesis” Septemer 7-8, 2006, Bethesda, MD.

Invited speaker, Third Residential Course on Developmental Cognitive Neurosciences. Mental retardation, Orvieto, Italy, November 15-17, 2006.

Invited speaker, NIH Workshop Angiogenesis in the Nervous System. “Defining the vascular phenotype in Sturge Weber Syndrome” Bethesda, MD December 11-13, 2006.


2. Invited and/or refereed local/regional meetings

Symposium entitled "Brain Imaging: Implications for the Diagnosis and Treatment of Neuropsychiatric Disorders" September 20, 1997, Dearborn, Michigan. "PET studies of serotonin synthesis in childhood autistic disorders."

Symposium entitled "Developmental Neuroimaging in Psychiatric Disorders"
Dearborn, MI, June 13, 1998, "Positron emission tomography studies in children with autism."

Conference sponsored by Early On Michigan entitled “Windows of Opportunity” October 29, 1999, Bay Harbor, Michigan, “Research in Childhood Autism.”

Symposium entitled “Cure Autism Now Illinois Chapter Fall Conference 1999: Bio-medical Update” September 28, 1999, St. Charles, Illinois, “PET imaging studies in autistic children.”

Psychiatrist Quarterly Conference of the Oakland County Community Health Authority, September 12, 1999, Bloomfield Hills, MI, “Autism research at Children’s Hospital of Michigan/Wayne State University.”

16th Annual Developmental Disabilities Conference, Michigan State University, April 4, 2000, Lansing, Michigan, “Application of PET to study children with autism.”

4th Annual Issues and Challenges: The Child with Special Health Care Needs, Children’s Hospital of Michigan, November 4, 2000, “Autism treatment and research.”

TSC Midwest Conference, October 1, 2005, Ann Arbor, Michigan, “Overview of Tuberous Sclerosis Complex: Management and Treatment.”

3. Invited seminars or lectures

Invited speaker, Grand Rounds, Division of Endocrinology, Department of Internal Medicine, Wayne State University, “HPA/HPO Axis in Borderline Personality Disorder,” May 30, 2007.

Invited speaker Johns Hopkins University School of Medicine/Kennedy Krieger Institute Distinguished Scientist Lecture Series, “Understanding alterations during brain development with PET: A guide to new treatment approaches for autism,” April 19, 2007.

Invited seminar, College of Pharmacy, Wayne State University, “Pharmacotherapy aimed at neuroplasticity in autism,” January 18, 2005.

Invited speaker, University of Michigan Autism and Communication Disorders Center Autism Lecture Series, “The Role of Altered Serotonin Mechanisms for Brain Development in Autism,” September 30, 2004.

Grand Rounds, Department of Psychiatry, Wayne State University, “Tuberous Sclerosis Complex: Genetics, Cell Biology, Behavior and Imaging,” January 21, 2004.

Invited speaker, Cellular and Clinical Neurobiology seminar series, Wayne State University, November 25, 2003.

Invited speaker, BIRD seminar series, Wayne State University, March 31, 2003.

Invited seminar speaker, Department of Anatomy, Wayne State University, April 30, 2003.

Grand Rounds, Child Psychiatry, Wayne State University, May 14, 2002, "The role of functional imaging in the design of interventions for autism."

Invited seminar, Molecular Imaging Seminar, May 10, 2002 University of Washington, Seattle, "Role of PET Imaging in Autism."

Invited seminar, Department of Pharmacology, Wayne State University, May 11, 2001, “Functional imaging in autistic children.”

Grand Rounds, Department of Pediatrics, Wayne State University, December 1, 2000, “PET Scanning research in Autism.”

Grand Rounds, Department of Dermatology, Wayne State University, September 6, 2000, “Sturge-Weber Syndrome: Overview of features and new research.”

Invited seminar, University of Michigan, Institute for Human Adjustment, Autism Faculty Seminar, March 31, 2000, “Role of functional imaging in autism.”

Invited seminar, Department of Pediatrics, Division of Child Development and Rehabilitative Medicine, University of Pennsylvania, October 5, 1999, “Alteration of brain serotonin synthesis in autism.”

Grand Rounds, Department of Pediatrics, Wayne State University, September 3, 1999, “Neuroimaging with PET in autistic children.”

Grand Rounds, Department of Neurology (Child Neurology), Wayne State University, May 21, 1999, “Measurement of serotonin synthesis with PET in neurological disorders.”

Grand Rounds, Department of Child Psychiatry, Wayne State University, April 13, 1999, “Alpha[C-11]methyl-L-tryptophan PET measures serotonin and kynurenine
pathway metabolism: Implications for study of psychiatric and neurological disorders.”

Grand Rounds, Department of Pediatrics, DeVos Children's Hospital, Grand Rapids, MI, September 1, 1998, "Recent developments in autism research."

Grand Rounds, Department of Radiology, University of Iowa, August 6, 1998, "Application of new tracers for Positron Emission Tomography."

Keynote speaker: Annual Research Day, Department of Psychiatry, Medical College of Ohio, Toledo, Ohio, April 9, 1998.

Killiam Lecture Series, Montreal Neurological Institute, McGill University, October 14, 1997, Montreal, Canada, "Alpha[C-11]methyl-L-tryptophan PET: Application to childhood disorders."

Grand Rounds, Department of Psychiatry, University of Alabama at Birmingham, May 6, 1997, "Altered brain serotonin synthesis in autism measured with PET."

Grand Rounds, Department of Neurology (Pediatric Neurology), Wayne State University, December 20, 1996, "Brain serotonin sysnthesis measured with alpha[C-11]methyl-tryptophan positron emission tomography in normal and autistic subjects."

Grand Rounds, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, December 18, 1996, "Altered brain serotonin synthesis in autism measured with PET"

Institute National de la Sante' et de la Recherche Medicale, Neurobiologie Cellulaire et Fonctionnelle, Faculte de Medecine Pitie-Salpetriere, May 1991, "Unlocking Vaults: Organelle in search of a function."

Dr. Nicole Le Douarin, College de France,Institute d'Embryologie Cellulaire et Moleculaire, May 1991, "Vault immunofluorescence in brain: New insights regarding the origin of microglia."

UC Irvine Department of Pharmacology Seminar, March 1990, "Clues about receptor regulation from in vivo ligand binding studies."

Beckman Institute of Neuroscience, City of Hope, Duarte, California. November 1989, seminar speaker, "Role of receptor-mediated endocytosis in the regulation of the D2 dopamine receptor."

Neurology 200 (Neurology Grand Rounds, UCLA) October 26, 1988. "Receptor dynamics of the dopamine system."