School of Medicine

Wayne State University School of Medicine

Dr. Otto Muzik, Ph.D.

Ph. (313) 993-2616
Fax (313) 993-3845

EDUCATION:

1970-78 Radetzky High School, Vienna, Austria

1978-84 Technical University of Vienna, M.S. in Physics

1986-88 Technical University of Vienna, Institute of Electron and X-ray Physics: Ph.D. in Medical Physics; Title of Thesis:"Contribution to modelling in PET: Design and verification of the [11C]methylglucose model" (Mentor : Prof. LudwigFeinendegen) Research performed in the Institute of Medicine - PET Center Nuclear Research Center Juelich, Germany

TRAINING:

1990 - 1993 Post Doctoral Fellow in the Cardiac PET Group
University of Michigan, Ann Arbor

FACULTY APPOINTMENTS:

11/2004 - present Associate Professor with tenure (50%)
8/2003 - 11/2004 Associate Professor with tenure (25%)
2/2001 - 8/2003 Associate Professor (tenure track)
  Department of Pediatrics & Radiology
1999 - 2/2001 Associate Professor FTA
  Department of Radiology
1994 - 1999 Assistant Professor (Research-Educator) FTA
  Wayne State University/Detroit Medical Center
  Children's Hospital of Michigan
1988 - 1990 Staff Ph.D. Physicist in the PET Group of the Juelich Institute of Medicine
  Nuclear Research Center (Juelich, Germany)

MAJOR PROFFESIONAL SOCIETIES:

  • Society of Nuclear Medicine
  • American Association of Physicist in Medicine

SERVICE:

PATIENT CARE
Providing high quality standards for all clinical PET procedures including PET scanner calibration / PET scanner quality control, design of efficient data acquisition protocols, development and modification of PET data analysis procedures, data networking within the PET Center and to other departments or institutions.

SCIENTIFIC ACTIVITIES:

2006 Development of software tools for the integration of PET, DTI and EEG modalities
  Implementation of Landmark-constrained Conformal Mapping of the cortex for the determination of homotopic cortical elements
  Acceptance testing of the GE Discovery STE PET/CT scanner
2005

Development of a software tool for the quantitative assessment of the connectivity strength of cortico-cortical and thalamo-cortical fiber tracts

  Implementation of advanced DTI analysis software
  Installation of the SPM2 image analysis environment
  Development of kinetic analysis software for the C11 leucine tracer
  Implementation of software to create parametric images of BP from dynamic PK11195 studies
  Implementation of microPET scanning and image analysis protocols in the NICU
  Development of a method to coregister microPET rat data with MR images on the R4 microPET
2004 Implementation of fMRI analysis software for pediatric data
  Development of diffusion tensor analysis software which allows fMRI information to be used for seed regions
  Implementation of 4T spectroscopy
  Development of software for thalamic segmentation of diffusion tensor data
2003 Acceptance testing and QC of microPET rodent scanner
  Development of software for advance image and kinetic analysis of microPET image data
  Development of diffusion tensor analysis software able to calculate parametric images of mean diffusivity and fractional
anisotropy.
  Development of white matter fiber tracking software using specialized Kalman filter
  Implementation of voxel-based morphometry using the SPM99 software package
2002 Objective localization of cortical abnormalities using geometric parcellation of the cortical shell and determination of cortical
abnormalities based on histogram analysis
  Creation of a Web-based autism database (java-beans)
2001 3D software tools to define three-dimensional volumes of interest in pediatric coregistered MRI/PET image volumes
  Quantification of spike frequency, amplitude and delay derived from interictal EEG data and development of an ORACLE
database to correlate EEG data with image data
  Installation and development of the MIAMI Fuse software package in order to coregister functional PET image data with
structural CT/MRI image data using a mutual information algorithm
2000 Installation of the ANALYZE software package in order to perform subtraction of ictal SPECT coregistered with MRI
(SISCOM)
  “Fuzzy” segmentation of SPGR MRI images in order to allow an improved partial volume correction of PET images
  Assessment of the SPM method in pediatric applications 
  Installation of the SPM software package in order to perform
statistical parametric mapping in children and adults.
1999 Development of a software package which allows full 3D assessment of cortical abnormalities, in particular bilateral abnormalities.
1998 Installation and development of the 3D-Tool software package in order to coregister intracranial electrodes on the cortical surface
of PET image volumes
  Determination of the absolute surface size of cortical abnormalities in PET/MRI coregistered image volumes
1997 Semiautomated image segmentation and cerebral parcellation in order to define automatically brain structures in MRI images
1996 Development of a segmentation routine to extract cortical surfaces from volumetric MRI image volumes
  Implementation of the Phong illumination model for 3D surface rendering
1995 Installation of 3D-PET data acquisition at the CHM PET Center
  Non-linear warping of brain data volumes to a standard Tallairach brain atlas
  Kinetic modelling of the alpha-methyl-Tryptophan PET tracer
  Semi-automated determination of extent and location of epileptic foci using an assymetry measure of flumazenil retention in pediatric
brain.
1994 Implementation of MRI/PET coregistration software based on MPITOOL and the Chang/Pelizzari method.
  Kinetic modelling of the C-11 Flumazenil PET tracer
  Development of a patient motion correction algotithm for dynamic PET brain image sequences
  Installation and testing of PET activation study software according to the Minoshima package and SPM.
1992-1993 Parametric imaging of myocardial perfusion using [13N]ammonia and the Patlak-approach
  Evaluation of the characteristics of the generator-produced tracer Cu-PTSM in dogs and in patients for quantitative analysis
of myocardial perfusion
  Comparison of regional heterogeneity of [13N]ammonia tracer distribution to Rb-82 and Cu-PTSM
  Assessment of cardiac adrenergic neuronal function following acute myocardial infarction by [11C]hydroxyephedrine
  Investigation of dead-time losses due to tomograph block detector design in protocols with a high initial activity in the left ventricle
  Statistical analysis of inter- and intraobserver variability in quantitative determination of myocardial blood flow using
[13N]ammonia
  Development of a cardiac software package (written in PV-Wave/IDL programming language) for quantification of dynamic [13N]ammonia PET studies incorporating 3D-apical sampling.
1991-1992 Investigation of automated region definition and in-plane/3D motion correction for cardiac [13N]ammonia PET imaging
  Assessment of myocardial viability based on Rb-82 tissue clearance kinetics
1990-1991 Evaluation of quantitative myocardial perfusion using dynamic PET and [15O]water and [13N]ammonia injection
techniques (Canine and patient studies)
1989-1990 Determination of 18FDG and 11C-Methylglucose model parameter identifiability using a singular value decomposition of the final
sensitivity matrix
1988-1989 Measurement of local glucose transport rate constant and free glucose pool in human brain using PET and 11C-Methylglucose:
Results in normal, Alzheimer and Huntington patients
1986-1988 Blood-brain-barrier kinetics of glucose in human brain analyzed by 11C-3-O-Methyl-D-glucose and PET


REVIEW

  • Ad hoc reviewer for Journal of Nuclear Medicine
  • European Journal of Nuclear Medicine
  • Epilepsia
  • Journal of Cerebral Blood Flow and Metabolism
  • Annals of Neurology
  • NeuroImage
  • Neurology
  • Journal of Medical Physics

UNIVERSITY COMMITTEES

2001 - present Curriculum and Evaluations Committee member in the Medical Physics Graduate Program
Department of Radiation Oncology & Department of Radiology
2001 - present Member, Information Technology (IT) Committee
Wayne State University School of Medicine
2001 - present Faculty Member, Institute for Scientific Computing
Wayne State University
2003 - present Admisstions Committee memeber in the Medical Physics Graduate Program
Department of Radiation Oncology & Department of Radiology
2000 - 2003 Children's Research Center of Michigan (CRCM)
Research Committee Member

TEACHING:

A. Formal Courses:

1996 - WSU Medical Physics Graduate Program
RAD 7010 Imaging Physics II (Winter Semester 2003 – 16 week program)
Required (core) course (2 credits)
2h lecture using laptop presentation, slides and overheads
Provided lecture notes and exam for 15 – 20 graduate students

2000 - WSU Medical Physics Graduate Program
RAD 7130 Nuclear Medicine Lab (Spring Semester 2002 – 16 week program)
Required (core) course (2 credits)
3h lab at the Radiation Oncology Center, PET Center and Nuclear Medicine Suite
Provided lecture notes and supervision for 15 – 20 graduate students during lab exercises

1996 - Radiological Physics Course for Radiology residents
Winter Semester 2003 (block of 6 lectures) 1.5h
Provide lecture notes for about 15 Radiology residents

2000 - WSU Radiation Therapy Technology Program
RT4220 Radionuclide Physics (3 lectures) 1.5h
Provided lecture notes for 10 undergarduate students


B. Student Advisor:

Ph.D. Thesis advisor for
Mark Smyczynski (9/2006 - present)
Respiratory motion in lung cancer
Iyad Jafar (3/2006 - present)
Automated detection of lung cancer based on PET/CT data

Ph.D. Thesis advisor for (together with Dr. Draghici from the Department of Computer Science):
Shoaib Ghias (3/2003 - 6/2006)
Software tools for pediatric neuroimaging

Ph.D. Thesis committee member for:
Haihao Sun (8/2000 – 2003)
Development of PET imaging agents and antineoplastic agents: The studies
of FAU and FMAU

MS Thesis advisor for (together with Dr. Draghici from the Department of Computer Science):
Siamak Pourabdullah (6/2001-12/2003)
Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci

K23 Career Development Award primary mentor for:
Eishi Asano, MD (3/2003 - present)
Quantitative multimodality analyses in pediatric epilepsy surgery

Supervisor for postdoctoral research assistants at the PET Center

Kenji Kagawa, M.D. 2001-2003
Krisztina Benedek, M.D. 2002-2003
Tomomi Kimiwada, M.D. 2003-2004
Bharatha Dasan Jadadeesan, M.D. 2003-2004
Thomas Eluvathingal, M.D. 2004-2006
Rajkumar Govindan, M.D. 2005- present
Carlos E. Batista M.D. res. Fellow 2006 - present
Chris Lai (student) summer 2006


GRANT SUPPORT:

Active: Michigan Technology Tri-Corridor (PI: O Muzik)
MTTC Period: 09/01/05-08/30/08
"Software tools for neuroimaging in epilepsy"
PI, 10% time effort
Total direct cost for entire project period: $ 395,000
Total projected award: $450,000

NINDS Research Grant (PI: HT Chugani)
RO1 NS 34488 Period: 9/1/05 to 8/31/10
"Localization of Epileptic Foci with PET in Children"
Co-Investigator, 20% time effort
Total direct cost for entire project period: $ 1,496,125.-
Total projected award: $ $1,948,541.-

NIH Research Grant (PI: C Juhasz)
R01 NS041922-01 A2 Period: 12/01/02 - 11-30-07
"Longitudinal neuroimaging in Sturge-Weber syndrome"
Co-Investigator, 5% time effort
Total direct cost for entire project period: $ 1,100,000.-
Total projected award: $ 1,465,350.-

NIH Research Grant (PI: Diane Chugani)
NS45151 Period: 12/01/03 - 11/30/08
"Tryptophan metabolism in children with epilepsy"
Co-Investigator, 10% time effort
Total award $925,000 direct costs

K23 Career Development Award (PI: Eishi Asano)
Quantitative multimodality analyses in pediatric epilepsy surgery
Primary Mentor
7/01/04 - 6/30/09. Total direct costs $728,380


Pending: NSF Research Grant (PI: Jing Hua)
NSF Period: 09/01/06 - 08/31/09
Quantitative assessment of fiber tract connectivity in the human brain
Co-Investigator: Otto Muzik

NIH Grant
Tryptophan metabolism in human brain tumors
PI: Csaba Juhasz
Agency: NCI. Type RO1 CA123451
Co-Investigator: Otto Muzik

DOD Prostate Cancer Research Program
PET imaging of cancer with fluoropyrimidine
PI: Tony Shields
Co-Investigator: Otto Muzik

R21 NIH/NIBIB
Human Copper Transporter 1 as Reporter Gene for Imaging
PI: Fangyu Peng
Co-Investigator: Otto Muzik


Past: NIBBI Research Grant (PI: O Muzik)
R21 DA015919-01 Period: 10/01/02-9/30/05
"Software tools for pediatric neuroimaging"
PI, 10% time effort
Total direct cost for entire project period: $ 300,000.-
Total projected award: $ 442,100.-

NIH Research Grant (PI: AF Shields)
RO1 CA 39566 Period: 4/1/05 – 3/31/07
“Labeled Thymidine: Development as a PET Imaging Agent”
Co-Investigator, 5% time effort
Total direct cost for entire project period: $ 900,000.-
Total projected award: $ 1,250,350.-

NICHD Research Grant (PI: O Muzik)
RO1 HD40007-01 Period: 9/29/00 - 9/28/03
“Ontogeny of human GABAA receptor complex measured with PET
PI, 20% time effort
Total direct cost for entire project period: $ 550,000.-
Total projected award: $ 684,750.-

CRCM Research Grant (PI: O Muzik)
“Development of software tools for pediatric neuroimaging”
Period: 01/01/00 - 12/31/00
PI, 10% time effort
Total direct cost for entire project period: $ 49,293.-

NINDS Research Grant (PI: DC Chugani)
RO1 HD34942 Period: 12/15/98 - 11/30/01
"Brain Serotonin Synthesis in Autism"
Co-Investigator, 10% time effort
Total direct cost for entire project period: $ 659,585.-

NINDS Research Grant (PI: CE Johansen)
DA-95-003 Period: 12/01/97 - 11/30/00
"Individual Differences in Biobehavioral Drug Response"
Co-Investigator, 10% time effort
Total direct cost for entire project period: $ 856,628.-

AHA Scientist Development Grant (PI: M DiCarli)
Period: 01/01/98 - 12/31/02
"Effects of Autonomic Neuropathy on Coronary Blood Flow in Patients With Diabetis Mellitus"
Co-Investigator, 5% time effort
Total direct cost for entire project period: $ 260,000.-
Total projected award: $ 361,213.-

NINDS Research Grant (PI: DC Chugani)
RO1 NS/RR38324 Period: 2/1/99 - 1/31/04
"Imaging Tryptophan Metabolism in Tuberous Sclerosis"
Co-Investigator, 10% time effort
Total direct cost for entire project period: $ 772,482.-
Total projected award: $ 1,029,718.-

PUBLICATIONS:

Completed Publications in Scientific Journals

Peer Reviewed Publications:

1. Altmann K, Muehlensiepen H, Muzik O. Cation transport by bone marrow cells from vitamin-E-deficient mice. Naturwissenschaften 1989;76:78-80.

2. Langen K, Coennen H, Roosen N, Kling P, Muzik O, Herzog H, Kuwert T, Stoecklin G, Feinendegen L. SPECT studies of brain tumors with L-[123-I]iodo- methyl tyrosine ([123-I]MT): First clinical results and comparison with PET and [124-I]MT. J Nucl Med 1990;31:281-286.

3. Schwaiger M, Muzik O. Assessment of myocardial perfusion by positron emission tomography. Am J Cardiol 1991;67:35D-43D.

4. Beanlands R, Muzik O, Hutchins G, Schwaiger M. Noninvasive quantification of myocardial perfusion using positron emission tomography. Coronary Artery Disease 1992, 3:281-290.

5. Beanlands R, Muzik O, Mintun M, Mangner T, Lee K, Petry N, Hutchins G, Schwaiger M. The kinetics of Copper-62-PTSM in the normal human heart. J Nucl Med. 1992; 33:684-690

6. Beanlands R, Muzik O, Mintun M, Nguyen N T, Petry N, Schwaiger M. The relationship between myocardial retention of Tc-99m teboroxime and
myocardial blood flow. J Am Coll Cardiol. 1992; 20:712-9

7. Muzik O, Beanlands R, Hutchins G, Mangner T, Nguyen N, Schwaiger M. Validation of Nitrogen-13-Ammonia Tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med 1993; 34:83-91

8. Muzik O, Beanlands R, Hutchins G, Mangner T, Wolfe E, Schwaiger M. Automated region definition for cardiac Nitrogen-13-Ammonia PET imaging. J Nucl Med 1993; 34:336-344

9. Allman K, Wieland D, Muzik O, DeGrado T, Wolfe E, Schwaiger M. Carbon-11 Hydroxyephedrine with positron emission tomography for
serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol 1993;22:368-75

10. Sawada S, Allman K, Muzik O, Beanlands R, Wolfe E, Jr., Gross M, Fig L, Schwaiger M. Positron emission tomography detects evidence of viability in rest Technetium-99m Sestamibi defects. J Am Coll Cardiol 1994;23:92-8

11. Beanlands R, Muzik O, Hutchins G, Wolfe E, Schwaiger M. Heterogeneity of regional [13N]ammonia tracer distribution in the normal human
heart: Comparison to Rb-82 and Cu-PTSM. J Nucl Cardiology 1994;1:225-35

12. Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using PET. Circulation 1994;90: 808-817

13. Sawada S, Muzik O, Beanlands R, Hutchins G, Wolfe E, Hutchins G, Schwaiger M. Interobserver and interstudy variability of myocardial blood flow and flow reserve measurements with N-13 ammonia labeled positron emission tomography. J Nucl Cardiology 1995; 2: 413-22

14. Beanlands R, Muzik O, Melon P, Sutor R, Sawada S, Muller D, Bondie D, Hutchins G, Schwaiger M. Noninvasive quantification of regional myocardial flow reserve in patients with coronary atherosclerosis using nitrogen-13 ammonia positron emission tomography. J Am Coll Cardiol 1995;26: 1465-75

15. VomDahl J, Muzik O, Wolfe E, Allman C, Hutchins G, Schwaiger M. Myocardial Rb-82 tissue kinetics assessed by dynamic PET as a marker of
myocardial cell membrane integrity and viability. Circulation 1996;93: 238-245

16. Muzik O, Paridon S, Singh T, Morrow R, Dayanikli F, DiCarli M. Quantification of myocardial blood flows and flow reserve in children with a history of Kawasaki disease and normal coronary arteries using positron emission tomography. J Am Coll Cardiol 1996; 28:757-62

17. Chakraborty P, Mangner T, Chugani D, Muzik O, Chugani H. A high-yield and simplified procedure for the synthesis of alpha-[C-11]methyl-L-tryptophan. Nucl Med Biology 1996; 23: 1005-8

18. Mueller A, Rothermel R, Behen M, Muzik O, Chakraborty P, Chugani H. Plasticity of motor organization in children and adults. Neuroreport 1997; 8: 3103-3108

19. Muzik O, Chugani D, Chakraborty P, Mangner T, Chugani H. Analysis of C-11 alpha-methyl tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab 1997; 17: 659-669

20. Mueller A, Chugani T, Muzik O, Rothermel R, Chakraborty P. Language and motor functions activate calcified hemispheres in patients with Sturge-Weber syndrome: a PET study. Child Neurology 1997; 12:431-437

21. Chugani D, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, DaSilva E, Chugani H. Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Ann Neurol 1997; 42: 666-669

22. Mueller A, Muzik O, Watson C, DaSilva E, Mangner T, Chakraborty P, Chugani H. Motor activation in the temporal lobe after perinatal middle cerebral artery stroke: a single-case PET study. AnnNeurol 1997; 42: 518-519

23. DaSilva E, Chugani DC, Muzik O, Chugani HT. Identification of frontal lobe epileptic foci in children using positron emission tomography. Epilepsia 1997; 38: 1198-1208

24. Mueller A, Rothermel R, Behen M, Muzik O, Mangner T, Chugani H. Receptive and expressive language activations for sentences: a PET study. NeuroReport 1997; 8: 3767-3770

25. Vinas FC, Zamorano L, Mueller A, Jiang Z, Chugani H, Fuerst D, Muzik O, Mangner T, Diaz FG. [O-15]water PET and intraoperative brain mapping: A comparison in the localization of eloquent cortex. Neurol Res 1997; 19: 601-608

26. DaSilva E, Chugani DC, Muzik O, Chugani HT. Landau-Kleffner Syndrome: Metabolic abnormalities in temporal lobe are a common feature. J Child Neurol 1997; 12: 489-95.

27. DiCarli M, Tobes M, Mangner T, Levine A, Muzik O, Chakraborty P, Levine B. Effects of cardiac sympathetic innervation on coronary blood flow. NEJM 1997; 336: 1208-15.

28. Chugani D, Muzik O, Chakraborty P, Mangner T, Chugani H. Human brain serotonin synthesis capacity measured in vivo with [C-11]alpha-methyl-tryptophan. Synapse 1998; 28: 33-43

29. Muzik O, Duvernoy C, Beanlands R, Sawada S, Dayanikli F, Wolfe E, Schwaiger M. Assessment of the diagnostic performance of quantitative flow measurements in normals and patients with angiographically documented CAD using [N-13]ammonia and PET. JACC 1998; 31: 534-40

30. Mueller A, Rothermel R, Behen M, Muzik O, Mangner T, Chakraborty P, Chugani H. Brain organization of language after early unilateral lesion: a PET study. Brain and Language 1998; 62: 422-451

31. Mueller A, Rothermel R, Behen M, Muzik O, Becker C, Fuerst D, Mangner T, Chugani H. Determination of language dominance by [O-15]water
PET in children and adolescents: A comparison with the Wada test. J Epilepsy 1998; 11: 152-161

32. Mueller A, Chugani C, Behen M, Rothermel R, Muzik O, Chakraborty P, Chugani H. Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography. Neuroscience Letters 1998; 245: 1-4

33. Mueller A, Rothermel R, Behen M, Muzik O, Downey R, Mangner T, Chugani H. Task-related activations in heterotopic barin malformations:
a PET study. Neuroreport 1998; 9: 2527-2533

34. Muzik O, Chugani DC, Shen C, DaSilva E, Shah J, Shah A, Canady A, Watson C, Chugani HT. An objective method for localization of PET
abnormalities: Validation with FDG-PET in normal controls and epilepsy surgery patients. Comp Assist Surgery 1998; 3(2): 74-82

35. Mueller A, Rothermel R, Behen M, Muzik O, Mangner T, Chugani H. Different patterns of language and motor reorganization following early left hemisphere lesion. Arch Neurol 1998; 55:1113-1119

36. Mueller A, Watson C, Muzik O, Chakraborty P, Chugani H. Motor organization after early middle cerebral artery stroke: a PET study . Ped Neurol 1998; 19: 294-8.

37. Mueller A, Rothermel R, Behen M, Muzik O, Mangner T, Chugani H. Developmental changes of cortical and cerebellar motor control: a clinical PET study with children and adults. J Child Neurol 1998; 13: 550-6

38. Bengel F, Hauser M, Duvernoy C, Kuehn A, Ziegler S, Stollfuss J, Beckmann M,  Sauer U, Muzik O, Schwaiger M, Hess J. Myocardial blood flow and coronary flow reserve late after anatomical correction of transposition of the great arteries. JACC 1998; 32: 1955-61

39. Muzik O, Shen C, DiCarli M. IDL software package for absolute quantification of myocardial blood flow based on [N-13]ammonia PET data. Computers in Cardiology 1998; 25: 33-36

40. Chugani D, Chugani H, Muzik O, Shah J, Shah A, Canady A, Mangner T, Chakraborty P. Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[C-11]-methyl-L-tryptophan PET. Annals Neurol 1998; 44:858-866

41. Mueller A, Chugani H, Muzik O, Mangner T. Brain organization of motor and language functions following hemisperectomy: A [O-15]water PET study. Child Neurol 1998, 13: 16-22

42. Niimura K, Chugani D, Muzik O, Chugani H. Cerebellar reorganization following cortical injury in humans: Effects of lesion size and age. Neurology 1999; 52: 792-797

43. Chugani D, Muzik O, Behen M, Rothermel R, Janisse J, Lee J, Chugani HT. Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children. Ann Neurol 1999; 45: 287-295

44. Juhasz C, Nagy F, Muzik O, Watson C, Shah J, Chugani HT. [C-11] flumazenil PET in patients with epilepsy with dual pathology. Epilepsia 1999; 40: 566-574

45. Muzik O, Janisse J, Ager J, Shen C, Chugani D, Chugani H. A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children. Prog Neuro-Psychoparmacol & Biol Psych 1999; 23: 589-600

46. Mueller A, Rothermel R, Behen M, Chakraborty P, Muzik O, Chugani H. Language organization in patients with early and late left-hemispheric lesion: a PET study. Neuropsychologia 1999; 37: 545-57

47. Mueller A, Behen M, Rothermel R, Muzik O, Chakraborty P, Chugani H. Brain organization for language in children, adolescents and adults with left hemisphere lesion: a PET study. Prog Neuro-Psychopharmacol & Biol Psychiat 1999; 23:657-68

48. DiCarli M, Bianco-Battles D, Landa M, Kazmers A, Groehn H, Muzik O, Gruberger G. Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus. Circulation 1999; 100: 813-19

49. Nagy F, Chugani D, Juhasz C, daSilva E, Muzik O, Kupsky W, Canady A, Watson C, Shah C, Chugani H. Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex. J Cereb Blood Flow Metab 1999; 19: 939-947

50. Chugani DC, Niimura K, Chaturverdi S, Muzik O, Fakhouri M, Lee ML, Chugani HT. Increased brain serotonin synthesis in migraine. Neurology 1999; 53:1473 - 79

51. Niimura K, Muzik O, Chugani DC, Shen C, Chugani H. [C-11] flumazenil PET: activity versus parametric images for the detection of neocortical epileptic foci. J Nucl Med 1999; 40: 1985-91

52. Mueller A, Behen M, Rothermel R, Chugani DC, Muzik O, Mangner T, Chugani HT. Brain mapping of language and auditory perception in high-
functioning autistic children: A PET study. J Autism Developmental Disorder 1999; 29: 19-31

53. Juhasz C, Nagy F, Watson C, daSilva E, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [C-11]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 1999; 53: 2037-2045

54. Chugani DC, Muzik O. Alpha[C-11]-methyl-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab 2000; 20: 2-9

55. Muzik O, daSilva E, Juhasz C, Chugani DC, Shah J, Nagy F, Canady A, von Stockhausen HM, Herholz K, Gates J, Frost M, Ritter F, Watson C, Chugani HT. Comparison of intracranial EEG with flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology 2000; 54: 171-79

56. Muench G, Nguyen N, Nekolla S, Ziegler S, Muzik O, Chakraborty P, Wieland D, Schwaiger M. Evaluation of sympathetic nerve terminals with [C-11]epinephrine and [C-11]hydroxyephedrine and positron emission tomography. Circulation 2000;101: 516-23.

57. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Relationship between EEG and PET abnormalities in clinical epilepsy. J Clinical Neurophys 2000; 17: 29-42

58. DiCarli M, Prcevski P, Singh T, Janisse J, Ager J, Muzik O, VanderHeide R. Myocardial blood flow, function and metabolism in repetitive stunning. J Nucl Med 2000; 41: 1227-34

59. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 2000; 55: 825-34

60. Muzik O, Chugani DC, Juhasz C, Shen C, Chugani HT. Statistical parametric mapping: Assessment of application in children. NeuroImage 2000; 12: 538-49

61. Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Annals Neurology 2000; 48: 88-96

62. Pfund Z, Chugani D, Juhasz C, Muzik O, Chugani H, Wilds I, Seraji-Bozorgzad N, Moore G. Evidence for coupling between glucose metabolism and glutamate cycling using FDG PET and 1H magnetic resonance spectroscopy in patients with epilepsy. JCBF 2000; 20: 871-78

63. Asano E, Chugani DC, Muzik O, Shen C, Juhasz C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson C, Chugani HT. Multimodality imaging for improved Detection of epileptogenic foci in tuberous sclerosis complex. Neurology 2000; 54: 1976-84

64. Singh TP, Greer K, Muzik O, Hammond RL, Stephenson LW, DiCarli M. Assessment of skeletal muscle ventricle tissue blood flow using positron emission Tomography. Artificial Organs 2001; 4: 306 - 12

65. Chugani DC, Muzik O, Juhasz C, Janisse J, Ager J, Chugani HT. Postnatal maturation of human GABAA receptors measured with PET. Ann Neurol 2001; 49:618 - 26

66. Singh TP, Humes RA, Muzik O, Kottamasu S, Karpawich PP, Di Carli MF. Impaired Myocardial Flow Reserve in Patients with a Systemic Right Ventricle after atrial switch repair. J Am Coll Card 2001; 37: 2120-5

67 Lee JS, Asano E, Muzik O, Chugani DC, Juhasz C, Pfund Z, Philip S, Behen M, Chugani HT. Sturge-Weber syndrome: Correlation between clinical course and FDGPET findings. Neurology 2001; 57: 189

68. Juhasz C, Chugani DC, Muzik O, Shah A, Shah J, Watson C, Canady A, Chugani
HT. Relationship of flumazenil and glucose PET abnormalities to neocortical
epilepsy surgery outcome. Neurology 2001; 56: 1650-8

69. Juhasz C, Behen M, Muzik O, Chugani DC, Chugani HT. Bilateral prefrontal and temporal neocortical hypometabolism in children with epilepsy and aggression. Epilepsia 2001; 42: 991-1001

70. Lee JS, Asanao E, Juhasz C, Pfund Z, Philp S, Behen M, Muzik O, Chugani DC, Chugani HT. Sturge-Weber syndrome with unihemispheric involvement: Correlation between clinical characteristics and FDG findings. Neurology 2001; 57:189-195

71. Juhasz C, Muzik O, Chugani DC, Shen C, Janisse J, Chugani HT. Prolonged vigabatrin treatment modifies developmental changes of GABAA receptor binding in young children with epilepsy. Epilepsia 2001; 42: 1320-26

72. Asano E, Chugani DC, Juhasz C, Muzik O, Chugani HT, Surgical treatment of West syndrome. Brain & Development 2001; 23: 668-76

73. Juhasz, C, Chugani HT, Muzik O, Chugani DC. Neuroradiological assessment of Brain structure and function and its implication in the pathogenesis of West syndrome. Brain & Development 2001; 23:488-95

74. Chugani HT, Behen M, Muzik O, Juhasz C, Nagy F, Chugani DC. Local brain functional activity following early deprivation: A study of post-institutionalized Romanian orphans. Neuroimage 2001, 6: 1290-301

75. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, Mangner TJ, Chakraborty PK, Chugani HT. Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 2001; 57:1269-1277

76. Shields T, Grierson JR, Muzik O, Stayanoff JC, Lawhorn-Crews J, Obradovich J, Mangner J. Kinetics of 3-Deoxy-3-[F18]fluorothymidine uptake and retention in Dogs. Molecular Imaging and Biology 2002; 4: 83-89

77. Pfund Z, Chugani DC, Muzik O, Juhasz C, Behen M, Lee J, Chakraborty P, Mangner T, Chugani HT. Alpha[C-11]Methyl-L-Tryptophan positron emission tomography in patients with alternating hemiplegia of childhood. J Child Neurol 2002; 17:253-60

78. Lee JS, Pfund Z, Juhasz C, Behen M, Muzik O, Chugani DC, Nigro M, Chugani HT. Altered regional brain glucose metabolism in Duchesne muscular atrophy. Muscle and Nerve 2002; 26: 506-12

79. Sun H, Collins J, Mangner T, Muzik O, Shields A. Imaging [F-18]1(-2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in dogs. Nucl Med Biology 2003; 30: 25-30

80. Asano E, Muzik O, Shah A, Juhasz C, Chugani D, Sood S, Janisse J, Ergun E, Ahn-Ewing J, Shen C, Gotman J, Chugani H. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. Epilepsia 2003, 44: 425 - 34

81. Pfund Z, Kagawa K, Juhasz C, Rubin M, Shen C, Lee JS, Chugani DC, Muzik O, Chugani HT. Quantitative analysis of gray and white matter volumes and glucose metabolism in the Sturge-Weber syndrome. J Child Neurol 2003, 18: 119-26

82. Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner TJ, Chakraborty PK, Sood S, Chugani HT. Alpha[C-11]Methyl-L-Tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003; 60: 960-8

84. Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn-Ewing J, Shen C, Gotman J, Chugani HT. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. Epilepsia. 2003; 44:425-34.

85. Singh TP, Muzik O, Forbes TF, DiCarli M. Positron emission tomography myocardial perfusion imaging in children with suspected coronary abnormalities. Pediatr Cardiol. 2003 Mar-Apr;24(2):138-44.

86. Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Evaluation with_a[11C]methyl-L-tryptophan PET for reoperation after failed epilepsy surgery. Epilepsia 2004;45:124-30.

87. Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Evaluation with_a[11C]methyl-L-tryptophan PET for reoperation after failed epilepsy surgery. Epilepsia 2004;45:124-30.

87. Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Sood S, Kagawa K, Benedek K, Sood S, Gotman J, Chugani HT. Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures. Clin Neurophys. 2004; 115: 2718-27

89. Shields T, Grierson J, Dohmen B, Machulla J, Stayanoff J, Lawhorn-Crews J, Obradovich J, Muzik O, Mangner T. Imaging proliferation in vivo with [F-18]FLT and PET. Nature Medicine 2004; 4(11):1334-6.

90. Duvernoy C, Martin J, Briesmiester K, Muzik O, Mosca L, Bargardi A. Myocardial blood flow reserve in response to hormone therapy in postmenopausal woman with risk factors for coronary disease. J Clin Endocrin and Metab 2004;89(6):2783-8.

91. Benedek K, Juhász C, Muzik O, Chugani DC, Chugani HT. Metabolic changes of subcortical structures in intractable focal epilepsy. Epilepsia 2004;45:1100-5

92. Sun H, Mangner T, Collins M, Muzik O, Douglas K, Shields A. Imaging DNA synthesis in vivo with [F-18]FMAU and Positron Emission Tomography. JNM 2005; 46: 292-6

93. Martin J, Briesmiester K, Bargardi A, Muzik O, Mosca L, Duvernoy C. Weight changes and obesity predict impaired resting and endothelium-dependent myocardial blood flow in postmenopausal woman. J Clin Cardiol 2005; 28: 13-18

94. Chandana S, Behen M, Juhasz C, Muzik O, Rothermel R, Mangner T, Chakraborty P, Chugani HT, Chugani DC. Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism. Int J Neuroscience 2005; 23: 171-82

95. Benedek K, Juhász C, Chugani DC, Muzik O, Chugani HT. Longitudinal changes of cortical glucose hypometabolism in children with intractable epilepsy. J Child Neurol 2005 (in press)

96. Kagawa K, Chugani DC, Asano E, Juhász C, Muzik O, Shah A, Shah J, Sood S, Kupsky WJ, Mangner TJ, Chakraborty PK, Chugani HT. Epilepsy surgery outcome in children with tuberous sclerosis evaluated with a-[11C]methyl-L-tryptophan PET. J Child Neurol 2005; 20: 429-38

97. Muzik O, Pourabdollah S, Juhasz, C, Chugani DC, Janisse J, Draghici S. Application of an objective method for localizing bilateral cortical FDG PET abnormalities to guide the resection of epileptic foci . IEEE Trans Biomed Eng. 2005 Sep; 52(9):1574-81

98 Sun H, Collins J, Mangner T, Muzik O, Shields A. Imaging the pharmacokinetics of [F-18]FAU in patients with tumors: PET studies. Cancer Chemotherap and Pharmacology 2005; 57: 343-8

99 Shields AF, Briston DA, Chandupatla S, Douglas KA, Lawhorn-Crews J, Collins JM, Mangner TJ, Heilbrun LK, Muzik O. A simplified analysis of [F-18]FLT metabolism and retention. Eur J Nuc Med & Mol Imaging 2005; 32: 1269-75

100. Khorsand A, Graf S, Pirich C, Muzik O, Kletter K, Dudczak R, Maurer G, Sochor H, Schuster E, Porenta G. Assessment of myocardial perfusion by dynamic N-13 ammonia imaging: Comparison between two tracer kinetic models. J Nucl Cardiol. 2005; 12: 410-7.

101. Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and propagation of epileptic spasms delineated on electrocorticography. Epilepsia 2005; 46: 1086-97

102. Sun H, Sloan A, Mangner TJ, Vaishanpayan U, Muzik O, Collins JM, Douglas K, Shields AF. Imaging DNA synthesis with [(18)F]FMAU and positron emission tomography in patients with cancer. Eur J Nucl Med 2005; 32: 15-22

103. Nimmagadda S, Mangner TJ, Sun H, Kleckner RW, Muzik O, Lawhorn-Crews J, Douglas K, Collins JM, Shields AF. Biodistribution and radiation dosimetry estimates of (1-(2-deoxy-2-[18F]fluoro-1-b-D-arabinofuranosyl)-5-bromouracil): PET imaging studies in dogs. J Nucl Med 2005; 46: 1916-22

104. Peng F, Wu J, Liu J, Lu X, Muzik O. Mouse Extra-hepatic Hepatoma Detected on microPET using Copper (II)-64 Chloride uptake Mediated by Endogenous Mouse Copper Transporter 1 Molecular Imaging and Biology, 2005; 7:325-329.

105. Duvernoy C, Martin J, Briesmiester K, Muzik O, Mosca L. Self-reported physical activity and myocardial flow reserve in postmenopausal women at risk for cardiovascular disease. J Woman Health 2006; 15(1): 45 - 50

106. Peng F, Lu X, Janisse J, Muzik O, Shields AF. PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2. J Nucl Med. 2006; 47(10):1649-52.

107. Sundaram SK, Muzik O, Chugani DC, Mu F, Mangner TJ, Chugani HT.Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue. J Nucl Med. 2006; 47(11):1787-95

108. Benedek K, Juhász C, Chugani DC, Muzik O, Chugani HT. Longitudinal changes of cortical glucose hypometabolism in children with intractable epilepsy. J Child Neurol 2006;21:26-30

109. Juhasz C, Chugani DC, Muzik O, Wu D, Sloan A, Barger G, Watson C, Shah A, Sood S, Ergun EL, Mangner T, Chakraborty P, Kupsky WJ, Chugani HT. In vivo uptake and metabolism of a-[11C]methyl-L-tryptophan in human brain tumors. J Cereb Blood Flow Metab 2006;26:345-57

110. Kimiwada T, Juhász C, Makki M, Muzik O, Chugani DC, Asano A, Chugani HT. Hippocampal and thalamic diffusion abnormalities in children with temporal lobe epilepsy. Epilepsia 2006;47:167-75

111. Eluvathingal T, Chugani HT, Behen ME, Juhász C, Muzik O, Maqbool M, Chugani DC, Makki M. Abnormal brain connectivity in children following early severe socio-emotional deprivation: a diffusion tensor imaging study. Pediatrics 2006;117:2093-100

112. Wakamoto H, Eluvathingal T, Makki M, Juhász C, Muzik O, Chugani HT. Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 2006;21:566-71

113. Eluvathingal TJ, Behen ME, Chugani HT, Janisse J, Bernardi B, Chakraborty P, Juhasz C, Muzik O, Chugani HT. Cerebellar lesions in tuberous sclerosis complex: neurobehavioral and neuroimaging correlates. J Child Neurol 2006;846-51

114. Juhász C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol 2007 (in press)

115. Juhász C, Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume is a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol 2007 (in press)

116. Muzik O, Chugani DC, Zou G, Hua J, Lu Y, Lu S, Asanao E, Chugani HT. Multimodality data integration in epilepsy. IJBI 2007 (in press)

117. Juhász C, Batista EA, Chugani DC, Muzik O, Chugani HT. Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome. Eur J Paediatr Neurol 2007 (in press)

118. Juhász C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol 2007 (in press)


Books

1. Muzik O, Herzog H, Langen K, Rota Kops E, Fulton R, Kuwert T, Feinendegen L. In Nuclear Medicine - Trends and Possibilities in Nuclear
Medicine edited by H Schmidt and G Buragi. Schattauer Verlag 1989; p 695-698.

2. Schwaiger M, Muzik O, Hutchins G. Assessment of myocardial perfusion with N-13 ammonia and Rb-82. In Cardiac Positron Emission Tomography edited by Markus Schwaiger. Kluwer Academic Publishers 1996; p 147-154

3. Muzik O, Chugani DC, Shen C, Chugani HT. Non-invasive imaging of serotonin synthesis rate using PET and alpha-methyl-tryptophan in autistic
children. In Quantitative Functional Brain Imaging with PET edited by R Carson, M Daube-Witherspoon and P Herscovitch. Academic Press 1998; p 201-206

4. Muzik O, Chugani DC, Shen C, Juhasz C, von Stockhausen HM, Chugani HT. Assessment of the performance of FDG and FMZ PET imaging against the gold standard of invasive EEG monitoring for the detection of extratemporal lobe epileptic foci in children. In Molecular and Pharmacological Brain Imaging with Positron Emission Tomography, eds. Gjedde A, Hansen SB, Knudsen GM, Paulson OB. Academic Press, San Diego, 381-387, 2001

5. Juhasz C, Chugani HT, Muzik O, Chugani D. Hypotheses from functional neuroimaging studies. In Epilepsy, Infantile Spasms and Developmental Encephalography, edited by Schwarzkron PA and Rho JM. Academic Press, San Diego, 38-56, 2002

6. Asano E, Juhasz C, Chugani DC, Muzik O, Chugani HT: Positron emission tomography: Localization for epilepsy surgery. In Reisin RC, Nuwer MR, Hallett M, Medina C (eds.), Advances in Clinical Neurophysiology, Supplements to Clinical Neurophysiology, vol. 54, Elsevier,, 2002, chapter 53, pp. 351-8.

7. Fitz C, Byrd S, Vezina G, Muzik O, Chugani HT. Brain: Imaging modalities. In Caffey's pediatric diagnostic imaging - 10th ed. Elsevier Inc (USA), pp 500-504, Chapter 2, 2004

8. Juhász C, Chugani DC, Muzik O, Chugani HT. Positron-Emission Tomography in epilepsy. In: Kuzniecky R & Jackson G (eds.), Magnetic resonance in epilepsy: and other neuroimaging techniques; 2nd edition. Academic Press 2004; 395-411)


Abstracts:

1. Muzik O, Herzog H, Patton D, Langen K, Wieler H, Feinendegen L. The effect of elevated blood glucose in the human brain. Eur J Nucl Med 1987;26:57.

2. Muzik O, Herzog H, Fulton R, Langen K, Kuwert, T, Feinendegen L. Modelling of a double-injection technique for combined control-stimulation studies of cerebral activation using PET and [18F]DG. Eur J Nucl Med 1989;15:453.

3. Muzik O, Beanlands R, Hutchins G, Mangner T, Wolpers G, Nguyen N, Schwaiger, M. Experimental validation of a tracer kinetic model for [13N]ammonia in comparison to [15O]water for the quantification of myocardial blood flow. J Nucl Med 1991;32:926.

4. Muzik O, vom Dahl J, Hutchins G, Schwaiger M. Comparison of regional 82Rb kinetics and FDG uptake in patients with previous myocardial infarction. J Nucl Med 1991;32:1012.

5. Henrich M, Vester E, Juelicher F, Muzik O, Herzog H, Grossmann K, Starauer. Myocardial glucose metabolism in patients with coronary artery occlusion: A FDG-PET study in the fasted state and after glucose load. J Nucl Med 1991;32:909.

6. Beanlands R, Muzik O, Nguyen N, Petry N, Schwaiger M. The relationship of 99mTc teboroxime retention and myocardial blood flow. J Nucl Med 1991;32:947.

7. Muzik O, Beanlands K, Lee K, Mintun M, Mangner T, Moskwa J, Hutchins G, Allman K, Petry N, Nguyen N, Schwaiger M. Investigation of myocardial perfusion using dynamic PET and generator produced 62Cu-PTSM. Eur J Nucl Med 1991;18:665.

8. Beanlads R, Muzik O, Sutor R, Melon P, Muller D, Hutchins G, Schwaiger M. Noninvasive determination of regional perfusion reserve in coronary artery disease. J Nucl Med 1992; 33:826

9. Melon P, Beanlands R, DeGrado T, Muzik O, Nguyen N, Petry N, Schwaiger M. Comparison of retention characteristics of Tl-201, Tc-99m-Sestamibi and Tc-99m-Teboroxime in canine myocardium. J Nucl Med 1992; 33:865

10. Muzik O, Beanlands R, Schwaiger M, Wolfe E, Hutchins G. New analysis approach for quantification of myocardial perfusion with PET using correction for patient motion and automated region definition. J Nucl Med 1992; 33:882

11. Muzik O, Behrendt D, Mangner T, Chugani H. Design of a pediatric protocol for quantitative brain FDG studies with PET not requiring invasive blood sampling. J Nucl Med 1994; 35:104

12. Chiao P, Muzik O, Rogers L. Evaluation of a model-based estimation method for dynamic cardiac studies.J Nucl Med 1994; 35:185

13. Muzik O, Paridon S, Mulla N, Dayanikli F. Quantification of regional myocardial blood flow and flow reserve in children with Kawasaki disease using positron emission tomography. Circulation 1994; 90: 2858

14. Chugani D, Chugani H, Mangner T, Muzik O, Chakraborty P. C-11 Flumazenil PET in children with epilepsy. J Nucl Med 1995; 36: 83

15. Chugani D, Chugani H, Mangner T, Muzik O, Chakraborty P. Localization of epileptic foci with C-11 flumazenil PET in children. J Cereb Blood Flow Metab 1995; 15: S179

16. Mueller A, Chugani H, Muzik O, Rothermel R, Chakraborty P. Localization of language functions after early perisylvanian lesion: a O-15 water PET study with children and adolescents. J Cereb Blood Flow Metab 1995; 15: S691

17. Mueller A, Chugani H, Muzik O, Mangner T, Nigro M. Involvement of non-motor cortex in motor control after early unilateral lesion: a O-15 water
PET study. J Cereb Blood Flow Metab 1995; 15: S692

18. Muzik O, Chugani D, Ding C, Mangner T, Chugani H. Automated operator-independent assessment of extent and localization of seizure foci in children with epilepsy using PET imaging. J Cereb Blood Flow Metab 1995; 15: S778

19. DiCarli M, Tobes M, Levine A, Muzik O, Mangner T, Rabkin G, Wynne J, Levine T. Effect of sympathetic neurons on basal myocardial blood flows and flow reserve in humans undergoing heart transplantation. J Nucl Med 1996; 37: 4P

20. Muzik O, Chugani D, Ding C, Chakraborty P, Mangner T, Chugani H. Analysis of C-11 Alpha-methyl tryptophan kinetics for the estimation of
serotonin synthesis rate in human brain using dynamic PET. J Nucl Med 1996;37: 145P

21. Muzik O, Shen C, Chugani DC. Improved positioning method to obtain the left ventricular input function for quantitative PET brain studies using anatomical information from the transmission scan. J Nucl Med 1997; 38:94P

22. Muzik O, Mueller A, Mangner TJ, Chugani HT. Performance comparison of pediatric O-15 water PET studies in 2D and 3D-mode during motor stimulation J Nucl Med 1997; 38:292P

23. Muzik O, Shen C, Chugani DC, DaSilva E, Chugani HT. Rendering of three-dimensional brain surfaces showing extent and localization of seizure foci in children with epilepsy based on FDG PET. J Cereb Blood Flow Metab 1997;17,1: S58

24. Muzik O, Chugani DC, Shen C, Chugani HT. Non-invasive imaging of serotonin synthesis rate using PET and alpha-methyl-tryptophan in autistic children. Neuroimage 1997; 5,4: B16

25. Muzik O, Chugani DC, Shen C, Chugani HT. Description of developmental changes in serotonin synthesis capacity in children using PET and [C-11]alpha-methyl-tryptophan. J Nucl Med 1998, 39: 124P

26. Muzik O, DiCarli M, Shen C, Chugani HT. Non-invasive determination of renal blood flow in pediatric patients using PET and the abdominal aorta as the arterial input function. J Nucl Med 1998; 39: 200P

27. Muzik O, Chugani D, Ager J, Janisse J, Shen C, Chugani HT. Developmental changes of serotonin synthesis capacity in children using PET and alpha[C-11] methyl-tryptophan. NeuroImage 1998; 7(4): A33

28. Muzik O, Shen C, DiCarli M. IDL software package for absolute quantification of myocardial blood flow based on [N-13]ammonia PET data. Computers in Cardiology 1998; S22

29. Muzik O, Shen C, Jones T, Chugani D. Comparison of OSEM iterative reconstruction with standard FBP for pediatric low-count PET brain studies in 3D-mode. J Nucl Med 1999; 5: 147P

30. Muzik O, vonStockhausen HM, Chugani D. A simple approach for the reliable correlation of subdural electrode grid data with neuroimaging data in extra-temporal epilepsy surgery planning. Epilepsia 1999; 40 (Suppl 2): 6

31. Muzik O, Chugani DC, Shen C, Juhasz C, Chugani HT. Statistical parametric mapping : Assessment of application in children. J Nucl Med
2000; 5: 62P

32. Muzik O, Juhasz C, Chugani DC, Chugani HT. Chronc Vigabatrin treatment modifies developmental changes of GABAA receptor binding in children with epilepsy. J Nucl Med 2001; 5: 38P

33. Muzik O, Chugani D, Juhasz DC, Chugani HT. Effect of chronic Vigabatrin treatment on benzodiazepine receptor binding in children with epilepsy. Epilepsia 2001; 42 (Suppl 2): 125

34. Muzik O, Pourabdollah S, Juhasz C, Draghici S, Chugani HT, Chugani DC. Objective method for localization of abnormal cortical glucose metabolism using 3D analysis of PET image data. J Nucl Med 2002; 43 (Suppl 5): 201P

35. Sun H, Mangner TJ, Muzik O, Collins JM, Douglas K, Shields AF. Imaging DNA synthesis in tumor patients with [F-18]FMAU and PET. J Nucl Med 2002; 43(Suppl 5): 26P

36. Nimgadda S, Mangner TJ, Muzik O, Sun H, Lawhorn-Crews J, Collins JM, Douglas K, Shields AF. Metabolic studies of [F-18]FBAU in dogs: A PET tracer For DNA synthesis. J Nucl Med 2002; 43 (Suppl 5): 27P

37. Bendaly EA, Sloan AE, Dohmen BM, Mangner TJ, Machulla HJ, Bares R, Muzik O, Shields AF. Use of [F-18]FLT PET to assess the metabolic activity of primary and metastatic brain tumors. J Nucl Med 2002; 43 (Suppl 5): 111P

38. Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Chugani HT. Decreased GABAA Receptor Binding and Increased Uptake of alpha-[11C]Methyl-L-Tryptophan on PET Can Independently Identify Human Epileptogenic Cortex. American Academy of Neurology Annual Meeting, Denver, CO, May 2002.

39. Juhász C, Chugani DC, Asano E, Shah A, Shah J, Muzik O, Sood S, Harry T. Chugani HT. _[11C]Methyl-L-tryptophan (AMT) PET scanning in 176 patients with intractable epilepsy, Annual Child Neurology Meeting, Oct 2002 Washington DC, ., Ann Neurol 2002;53 (suppl. 1):S118.

40. Chugani DC, Pfund Z, Chandana S, Behen ME, Muzik O, Juhasz C, Lee J. GABAA receptors measured with [C-11]flumazenil PET in children with autism, Angelman and Landau-Kleffner syndromes. International Meeting for Autism Research, Orlando, Florida, Novermber 2002.

41. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Sood S, Mangner T, Chakraborty PK, Chugani HT. _[11C]Methyl-L-tryptophan (AMT) PET can detect residual epileptic cortex following failed cortical resection in children with intractable epilepsy. American Epilepsy Society Meeting Dec 2002 (submitted).

42. Chugani HT, Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK. Surgery for intractable infantile spasms: the role of _[11C]Methyl-L-tryptophan (AMT) PET scanning. American Epilepsy Society Meeting Dec 2002.

43. Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn Ewing J, Shen C, Gotman J, Chugani HT. Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):43-44

44. Juhász C, Chugani DC, Asano E, Shah A, Shah J, Muzik O, Sood S, Chugani HT. _[11C]Methyl-L-tryptophan (AMT) PET scanning in 176 patients with intractable epilepsy, Annual Child Neurology Meeting, Oct 2002 Washington DC., Ann Neurol 2002;53 (suppl. 1):S118.

45. Juhasz C, Chugani DC, Muzik O, et al. Decreased GABA(A) receptor binding and increased uptake of alpha-[C-11]methyl-L-tryptophanon PET can independently identify human epileptogenic cortex. Neurology 58 (7): A150-A150 Suppl. 3 Apr 2002

46. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Sood S, Mangner T, Chakraborty PK, Chugani HT. _[11C]Methyl-L-tryptophan (AMT) PET can detect residual epileptic cortex following failed cortical resection in children with intractable epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):126-127.

47. Chugani HT, Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK. Surgery for intractable infantile spasms: the role of _[11C]Methyl-L-tryptophan (AMT) PET scanning. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):75-76.

48. Kagawa K, Juhasz C, Chugani DC, Muzik O, Chugani HT. Maximal reduction of N-acetylaspartate in metabolic border zone of fluorodeoxyglucose-positron emission tomography in nonlesional extratemporal lobe epilepsy. American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):76.

49. Kagawa K, Asano E, Juhasz C, Muzik O, Janisse J, Shah A, Sood S, Mangner TJ, Chakraborty PK, Chugani HT, Chugani DC. Surgical treatment and outcome in children with tuberous sclerosis complex and intractable epilepsy in relation to _[11C]methyl-L-tryptophan PET. American Academy of Neurology, March 29-April 5, Honolulu. Neurology 2003 (Suppl. 1);60:A448-9.

50. Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Benedek K, Shah J, Sood S, Gotman J, Chugani HT. Quantitative ictal subdural EEG analysis in children with intractable neocortical epilepsy. American Academy of Neurology, March 29-April 5, Honolulu. Neurology 2003 (Suppl. 1);60:A450.

51. Juhasz C, Chugani DC, Heyes M, Muzik O, Chander S, Ergun EL, Sloan A, Sood S, Shah A, Watson C, Chugani HT. Tryptophan metabolism in epileptogenic brain tumors: a PET study using alpha[11C]methyl-L-tryptophan (AMT). American Academy of Neurology, March 29-April 5, Honolulu. Neurology 2003 (Suppl. 1);60:A6-7.

52. Siamak Pourabdollah, Otto Muzik, Sorin Draghici. A Back Propagation Neural Network for Localizing Abnormal Cortical Regions in FDG PET Images in Epileptic Children. International Work Conference on Artificial and Neural Networking, Spain, 2003 (platform presentation)

53. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Shah J, Sood S, Kagawa K, Benedek K, Chugani HT. Cortical GABAA receptor-binding abnormalities remote from the primary epileptic focus: what are their electrophysiologic and clinical significance? Epilepsia 2003; 44 (Suppl 9):311-312. (Poster presentation; Annual Meeting of the American Epilepsy Society, Boston, MA, December 5-10, 2003)

54. Chugani HT, Juhász C, Behen M, Ondersma R, Muzik O, Chugani DC. Autism with facial port-wine stain: a new syndrome? Ann Neurol 2003;54 (suppl 7):S129 (Poster presentation; Annual Meeting of the Child Neurology Society, October 2003, Miami, FL)

55. Muzik O, Kagawa K, Juhász C, Chugani HT, Chugani DC. Pattern of GABA-A receptor distribution in children with epilepsy. Epilepsia 2003;44(Suppl.8):183-184. (Poster presentation;25th International Epilepsy Congress, Lisbon, Portugal, 12-16 October, 2003)

56. Asano E, Benedek K, Shah A, Juhász C, Muzik O, Chugani DC, Sood S, Chugani HT. Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? Epilepsia 2003; 44 (Suppl 9):163-164. (Platform presentation; Annual Meeting of the American Epilepsy Society, Boston, MA, December 5-10, 2003)

57. Muzik O, Pourabdollah S, Juhasz C, Chugani DC, Draghici S, Chugani HT. Quantitative assessment of the spatial relationship between electrophysiological and functional data in the cortex of epileptic children. J Nuc Med 2003; 44 (5) (Suppl): 13P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

58. Muzik O, Kagawa K, Juhasz C, Chugani HT, Chugani DC. Non-invasive imaging of the GABA-A receptor complex in children with epilepsy using PET. J Nuc Med 2003; 44 (5) (Suppl): 245P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

59. Sun H, Muzik O, Shields AF. Radiation dosimetry estimates of [f-18]FMAU and [F-18]FAU. J Nuc Med 2003; 44 (5) (Suppl): 321P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

60. Sun H, Collins JM, Mangner T, Muzik O, Douglas K, Shields AF. Imaging biodistribution of [F-18]FAU via PET in patients with tumors. J Nuc Med 2003; 44 (5) (Suppl): 321P. (Poster presentation; Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA, June 21-25, 2003)

61. Muzik O, Pourabdollah S, Juhasz C, Chugani DC, Draghici S, Chugani HT. Application of an objective method for localizing bilateral cortical abnormalities to guide the resection of epileptic foci. Brain 2003; 23 (suppl 6): S659 (Poster presentation; BrainPET '03, Calgary, Canada 29 June 29 - 3 July, 2003)

62. Nimmagadda S, Mangner T, Muzik O, Sun H, Lawhorn-Crews J, Douglas K, Collins JM, Shields AF. [F-18]FIAU imaging in dogs with PET. J Molecular Imag and Biology 2003; 5 (3): 120P (Poster presentation; International Conference of the Academy of Molecular Imaging, Madrid, Spain, September 21-27)

63. Maiti D, Chakraborty PK, Chugani DC, Muzik O, Mangner T, Chugani HT. An improved synthesis procedure for routine production of [Carbonyl-11C] desmethyl-way-100635. J Labeled Compounds and Radiopharmaceuticals 2003; 46 (8) (suppl 1): S233. (Poster presentation, 15th International Symposium on Radiopharmaceutical Chemistry, Sydney, Australia, 10-14 August 2003).

64. Juhász C, Chugani DC, Muzik O, Sloan A, Barger G, Watson C, Sood S, Chugani HT. PET imaging of recurrent brain tumors using __[11C]methyl-L-tryptophan. Accepted for presentation at the Annual Meeting of the American Academy of neurology, April 29, 2004, San Francisco, CA.

65. Liu J, Wu S, Lu X, Muzik O, Peng F. Utilization of human copper transporter 1 for imaging cell trafficking in vivo by copper-64 positron emission tomography. Poster presentation at the 12 Congress of the European Society of Gene Therapy, November 4, 2004, Tampere, Finland

66. Liu J, Wu S, Lu X, Mangner T, Chakraborty P, Mu F, Muzik O, Peng F. Comparative study of multiple radiopharmaceuticals for positron emission tomography of neuroblastoma. Oral presentation at the 96th annual meeting of AACR, April 16, 2004, Anaheim, CA

67. Juhász C, Chugani DC, Muzik O, Sloan A, Barger G, Watson C, Sood S, Chugani HT. PET imaging of recurrent brain tumors using alpha[C-11]methyl-L-tryptophan. Neurology 2004;62(Suppl 5): A470. (Poster presentation; 56th Annual Meeting of the American Academy of Neurology, San Francisco, CA, April 24 – May 1, 2004)

68. Juhász C, Muzik O, Chugani DC, Hu J, Chugani HT. Frontal lobe magnetic resonance spectroscopic imaging (1H-MRSI) and FDG PET abnormalities in young children with Sturge-Weber syndrome. 10th Annual Meeting of the Organization Organization for Human Brain Mapping, Budapest, Hungary, June 13-17, 2004

69. Jagadeesan BD, Behen M, Makki M, Muzik O, Juhász C, Chugani DC, Chugani HT. Abnormal brain connectivity in children with early severe social deprivation: diffusion tensor imaging study. Ann Neurol 2004;56(suppl 8):S91. (Presented at the Annual Meeting of the Child Neurology Society, Ottawa, Canada, October, 2004)

70. Kagawa K, Chugani DC, Behen M, Chandana SR, Juhász C, Muzik O, Chugani HT. Altered brain growth in children with tuberous sclerosis complex and autism. Ann Neurol 2004;56(suppl 8):S93. (Presented at the Annual Meeting of the Child Neurology Society, Ottawa, Canada, October, 2004)

71. Behen M, Solomon K, Luan Phan K, Makki M, Fitzgerald DA, Muzik O, Juhász C, Jagadeesan BD, Chugani DC, Chugani HT. Brain activation during emotional face recognition in children with early social deprivation. Ann Neurol 2004;56(suppl 8):S94. (Presented at the Annual Meeting of the Child Neurology Society, Ottawa, Canada, October, 2004)

72. Behen ME, Chandana SR, Rothermel R, Muzik O, Juhász C, Chugani HT, Chugani DC. Lateralized cortical serotonergic abnormalities in autistic children are associated with social subtypes. Ann Neurol 2004;56(suppl 8):S95. (Presented at the Annual Meeting of the Child Neurology Society, Ottawa, Canada, October, 2004)

73. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Shah J, Sood S, Chugani HT. Flumazenil PET in children with intractable partial epilepsy or infantile spasms: does it provide additional localizing information? Epilepsia 2004;45(suppl 7):366. (Platform presentation at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004)

74. Asano E, Juhász C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Analysis of intracranial electrocorticography in children with epileptic spasms. Epilepsia 2004;45(suppl 7):249. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004)

75. Kimiwada T, Juhász C, Makki M, Jagadeesan BD, Muzik O, Chugani DC, Chugani HT. Thalamic and hippocamnpal diffusion tensor imaging (DTI) abnormalities in children with temporal lobe epilepsy. Epilepsia 2004;45(suppl 7):295. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004)

76. Eluvathingal T, Juhász C, Chugani DC, Kagawa K, Muzik O, Shah A, Asano E, Sood S, Chugani HT. a-[11C]Methyl-L-tryptophan (AMT) PET can localize epileptogenic tubers when scalp EEG is poorly localizing in children with tuberous sclerosis. Epilepsia 2004;45(suppl 7):296-7. (Presented at the Annual Meeting of the American Epilepsy Society, New Orleans, LA, Dec. 3-7, 2004)

77. Asano E, Rothermel R, Behen M, Muzik O, Chugani DC, Pawlak C, Janisse J, Ager J, Chugani HT. Occipital alpha peak frequency during quiet wakefulness is an independent predictor of cognitive function in children with focal epilepsy. Epilepsia 2005; 46( Suppl. 8): 140-141.

78. Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Sood S, Chugani HT. Quantitative analysis of ictal electrocorticography in children with tuberous sclerosis complex. Epilepsia 2005 (Suppl. 8): 313.

79. Wakamoto H, Eluvathingal T, Makki M, Behen ME, Juhasz C, Muzik O, Senthil S, Chugani DC, Chugani HT. Diffusion tensor imaging of the corticospinal tracts after cerebral Hemispherectomy. Annals of Neurology 2005; 58 (Suppl. 9): 94.

80. Eluvathingal TJ, Behen ME, Makki M, Juhasz C, Muzik O, Chugani DC, Chugani HT. Abnormal language network is associated with language dysfunction in children subjected to early social deprivation: A diffusion tensor imaging study. Annals of Neurology 2005; 58 (Suppl. 9):94-95.

81. Behen ME, Eluvathingal TJ, Bernardi B, Janisse J, Juhasz C, Muzik O, Chugani DC, Chugani HT. Cerebellar lesions in patients with tuberous sclerosis complex: Neuroimaging and neurobehavioral findings. Annals of Neurology 2005; 58 (Suppl. 9) 95.

82. Asano E, Juhasz C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and propagation of epileptic spasms delineated on electrocorticography. Epilepsia 2005; 46 (IS 7) 1086-1097.

83. Muzik O, Sundaram S, Mu F, Mangner TJ, Chugani DC, Chugani HT. A simplified approach for determining an index of brain protein synthesis using 1-[11C]-leucine PET. J Nucl Med 2005, 46(2): 124P

84. Muzik O, Sundaram, S, Mu, F, Mangner, T, Chugani, DC, Chugani, HT. Semi-Quantitative Assessment of Brain Protein Synthesis Using L-[1-11C]-leucine PET. J Neurol Sci 2005; 238 (1): S258

85. Heckenberg G, Xi Y, Duan Y, Hua J, Muzik O. Thalamus Segmentation from MRI Images by Lagrangian Surface Flow. In Proceedings of 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS05) 2005: 3039 - 3042

86. Pai D, Jiang J, Hua J, Duan Y, Muzik O, Lu S. Segmentation of Brain Structures Using PDE-Driven Dynamic Growing. In Proceedings of the NAFIPS Annual Conference on Soft Computing for Real World Applications 2005: 424 - 428

87. Zou G, Hua J, Gu X, Muzik O. An Approach for Intersubject Analysis of 3D Brain Images based on Conformal Geometry. In Proceedings of IEEE International Conference on Image Processing, 2006: 1193 - 1198

88. Sundaram S, Chugani D, Munian Govindan R, Asano E, Juhász C, Chakraborty P, Muzik O, Sood S, Chugani HT. Alpha-methyl-L-tryptophan positron emission tomography (AMT-PET) predicts surgical outcome in children with intractable neocortical epilepsy. Ann Neurol 2006; 60(3): S137.

89. Muzik O, Sundaram S, Chugani DC, Mu F, Mangner TJ, Chugani HT. Determination of an index of protein synthesis (IPS) in brain using 1-[11C]-leucine PET: Effect of large neutral amino acid plasma levels and recycled tissue amino acids. J Nucl Med 2006; 47(1): 12P

90. Juhász C, Haacke EM, Hu J, Muzik O, Chugani DC, Chugani HT. Susceptibility weighted imaging (SWI) in Sturge-Weber syndrome: relation to cortical hypometabolism and seizures. Presented at the 1st North American Regional Epilepsy Congress / Annual Meeting of the American Epilepsy Society, San Diego, CA, December, 2006.

91. Pai D, Zou G, Hua J, Muzik O. A Conformal and Statistical Analysis Method for Objective Detection of PET Abnormalities. In Proceedings of the Ninth International Conference on Computer Graphics and Imaging, 2007 (in press).

92. Muzik O, Hua J, Pai D, Zou G, Makki M, Chugani D, Asano E, Chugani H. EPITOOL - software for integrative analysis of functional, anatomical and electrophysiological data in epilepsy. BrainPET 2007, Osaka, Jp

93. Muzik O, Hua J, Makki M, Chugani D, Asano E, Chugani H. A multimodality framework for integrative analysis of functional, anatomical and electrophysiological data in epilepsy. SNM 2007, Washington DC


EXTRAMURAL INVITED PRESENTATION

"Three-dimensional quantification of myocardial blood flow by [13N]ammonia and PET.
invited lecture, American Heart Association of Michigan, Parke-Davis Pharmaceutical
Research Division, Ann Arbor, MI, September 1991

“Non-invasive quantification of PET studies in children”. Invited speaker, NIDA
intramural research program, Baltimore, MD, May 2000

“AMT PET imaging in pediatric epilepsy”. Invited speaker, Department of Neurology,
Mayo Clinic, Rochester, MN, September 2000

“PET in pediatric epilepsy”. Invited Speaker at CTI User’s meeting: Barcelona, Spain
October 2000

“Mathematical Models for the analysis of pediatric functional images”. Invited speaker
at the NIH Pediatric Pharmacology Research Unit (PPRU) Network meeting: Detroit, MI,
April 2001

"PET imaging in theory and practice", Invited speaker, Michigan Department of Consumer
& Industry Services: Detroit. July 10, 2003

"Molecular imaging using PET". Invited Speaker, Karmanos Cancer Institute Research
Retreat: Detroit, August 22, 2003

"Statistical issues in PET data modeling". Invited speaker, Center for Health Care
Effectiveness Research: Detroit, March 10, 2004.

"Pediatric research applications of PET". Noon lecture, Department of Radiology.
Detroit, May 20 2004

"Application of advanced PET imaging for epilepsy surgery". Invited speaker,
Computer Assisted Surgery Annual Research Meeting: Detroit, June 4, 2004

"PET in pediatric imaging". Invited speaker - Categorical Seminar. Philadelphia,
June 19, 2004

"Role of PET in pediatric pharmacology studies". Invited speaker, PPRU Network
Steering Committee meeting, Bethesda, MD, October 20, 2005