School of Medicine

Wayne State University School of Medicine

Pulak Chakraborty, Ph.D.

 

Ph. (313) 993-3853
Fax (313) 993-3845

 

 

EDUCATION:

1975                B.Sc. (Hons.), Chemistry Indian Inst. of Technology, Kharagpur, India
1977                M.Sc. (Chemistry), Special : Organic Chemistry Indian Inst. of Technology, Kharagpur, India
1983                Ph. D., Chemistry Calcutta University, India


TRAINING:

1985-1986            Post-doctoral Research Associate, Dept. of Chemistry University of Illinois, Urbana-Champaign
1986-1989            Senior Research Fellow, College of Pharmacy University of Michigan, Ann Arbor
1989-1991            Post-doctoral Fellow, Nuclear Medicine Division University of Michigan, Ann Arbor


ACADEMIC APPOINTMENTS:

1977-1983    Research Fellow (CSIR), Dept. of Medicinal Chemistry Indian Institute of Chemical Biology
                     Calcutta, India
1983-1984    Research Associate (CSIR), Dept. of Medicinal Chemistry Indian Institute of Chemical Biology
                     Calcutta, India
1991-1993    Research Investigator, Nuclear Medicine Division
                     University of Michigan, Ann Arbor
1994 -           Chemist
                     Pediatric Imaging Dept.
                     Children’s Hospital of Michigan, Detroit, MI
1994 - 2006  Assistant Professor (Clinician – Educator), Full – Time Affiliate
                     Department of Radiology
                     Wayne State University
                     Detroit, MI
2006 -           Associate Professor (Clinician – Educator), Full – Time Affiliate                   
                     Department of Radiology
                     Wayne State University
                     Detroit, MI

MAJOR PROFESSIONAL SOCIETIES:

Member, American Chemical Society, 1987-
Member, Division of Medicinal Chemistry (ACS), 1988-
Member, Society of Nuclear Medicine, 1989-1991
Member, Society of Radiopharmaceutical Chemistry 2003-

HONORS/AWARDS:
National Scholarship (Awarded by Govt. of India), 1975-1977
Junior Research Fellowship (Awarded by Govt. of India), 1977-1979
Senior Research Fellowship (Awarded by Govt. of India), 1979-1983
National Research Service Award (USA), 1989-1991

SERVICE: 

Committee Service:

Member, Radiation Safety Committee (1997), Children’s Hospital of Michigan

Patient care:

  1. Synthesis of radiopharmaceuticals for clinical PET applications
  2. Perform quality control, sterility and pyrogen testing procedures of all the radiopharmaceuticals to be injected for the safety of the patients
  3. Synthesis of new PET radiopharmaceuticals as they are being evaluated for future clinical applications


Professionally related service:

  1. Perform research into the development of new PET radiopharmaceuticals for clinical PET applications
  2. Prepare necessary documentation (i.e. for FDA etc) for new radiopharmaceuticals
  3. Participate in the writing of grant proposals
  4. Participate in teaching laboratory personnel

TEACHING:
M.S. Thesis committee member for:
Cynthia Husk                Basic Medical Sciences (WSU, 2000-2001)

Supervisor for Postdoctoral Fellow:
Dilip Maiti, Ph.D.            PET Radiochemistry (WSU, 2002-2004)

Wayne State University:

Radiology 7010, Winter 2001 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Production of Radionuclides"
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”

Radiology 713, Winter 2001 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry

Radiology 7010, Winter 2002 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”

Radiology 713, Winter 2002 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry

Radiology 7010, Winter 2003 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”

Radiology 713, Winter 2003 (Course Director: Otto Muzik, Ph. D.)
2.0 h Laboratory Exercise in radiochemistry

Radiology 7010, Winter 2004 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Detection of Radioactive Decay”
2.0 h Lecture entitled "Radiopharmacy”

Radiology 7010, Winter 2005 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”

Radiology 713, Winter 2005 (Course Director: Otto Muzik, Ph. D.)
4.0 h Laboratory Exercise in radiochemistry

Radiology 7010, Winter 2006 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”

Radiology 7010, Winter 2007 (Course Director: Otto Muzik, Ph. D.)
2.0 h Lecture entitled "Radiopharmacy”

Several lectures for students and staffs at the PET Center on radiochemistry and PET radioligands
Developments, 1994-

GRANT SUPPORT:
University of Michigan, Ann Arbor

Evaluation of cardiac autonomic innervation by PET
PI:  M. Schwaiger, M. D.
Role:  Co-investigator
Source:  NIH (5 Years period while in Univ. of Michigan)

Non-invasive evaluation of the cardiac autonomic nervous system by PET
PI:  M. Schwaiger, M. D.
Role:  Co-investigator
Source:  DOE (1 Year period while in Univ. of Michigan)

Wayne State University

Past:
Brain serotonin synthesis in autism
PI:  Diane C. Chugani, Ph. D.
Role:  Co-investigator
5% Effort
Agency: NIH
Type: R01 HD34942
Funded for period 12/15/98 to 11/30/01

Radiopharmaceutical tracers for neural progenitor cells
PI: Thomas J. Mangner, Ph. D.
Role: Co-investigator
10% Effort
Agency: DOE
Funded: 08/15/03-08/14/05
Total award $300,000 direct costs per year

Active:
Longitudinal neuroimaging in Sturge-Weber Syndrome
PI:  Csaba Juhász MD, PhD
Role: Co-investigator
5% Effort
Agency: NINDS
Type: RO1-NS041922-01
Period: 7-1-03 to 6-30-07
Total award $1,100,000 direct costs

PUBLICATIONS:
1. Nasipuri D, Sarkar A, Chakraborty PK, De Dalal I:  (1976) Heterocyclic systems part III. Sulphurisation of 1-aryl-3-oxocyclohexenes as a convenient route to hydrobenzonaphthothiophene derivatives.  J. Indian Chem. Soc. 4:1232-1234.

2. Ali E, Chakraborty PK and Pakrashi SC:  (1982) Condensation of  2- hydroxytryptamine with dimethyl 4- ethyl- 4- formyl pimelate. Heterocycles; 9:1367-1370.

3. Ali E, Chakraborty PK, Chakraborty AK, Pakrashi SC:  (1982) Synthesis and stereochemistry of ( + )- Vincatine.  Heterocycles, 19:1667-1671.

4. Ali E, Roy S, Chakraborty PK, Pakrashi SC:  (1983) Synthesis and absolute stereochemistry of ( - )- Vincatine.  Tetrahedron Letters, 24:2497-2500.

5. Coates RM, Hegde S, Koch SC, Chakraborty PK:  (1985) A new synthesis of chiral methyl groups via supertritide reduction. Elucidation of the methyl-methylene stereochemistry in kaurene biosynthesis.  Synth. Appl. Isot. Labelled Compd., Proc. Int. Symp., 207-212.

6. Rosman LB,  Chakraborty PK, Messerly EA, Sinsheimer JE:  (1988) Mutagenicity of aromatic glycidyl ethers with Salmonella.  Mutation Research, 206:115-125.

7. Sinsheimer JE, Chakraborty PK, Messerly EA, Gaddamidi V:  (1989) Mutagenicity of oxaspiro compounds with Salmonella.Mutation Research; 224:171-175.

8. Giri AK, Messerly EA, Chakraborty PK, Hooberman BH, Sinsheimer JE:  (1990) DNA strand breaks in liver for four aliphatic epoxides in mice.  Mutation Research; 242:187-194.

9. Chakraborty PK, Kilbourn M:  (1991) Oxidation of substituted 4-fluorobenzaldehydes: Application to the no-carrier-added syntheses of 4-[18F]fluoroguaiacol and 4-[18F]fluorocatechol.Applied Radiat. Isotopes, 42: 673-681.

10. Chakraborty PK, Kilbourn MR:  (1991) [18F]Fluorination/Decarbonylation : New route to aryl[18F]fluorides.  Applied Radiat. Isotopes, 42: 1209-1213.

11. Van Dort M.E, Kilbourn M. R, Chakraborty PK, Richfield EK, Gildersleeve DL, Wieland DM: Iodine-125 and Fluorine-18 labeled aryl-1,4-dialkylpiperazine :  (1992) Potential radiopharmaceuticals for in vivo study of the dopamine uptake system. Applied Radiat. Isotopes, 43: 671-680.

12. Hooberman BH, Chakraborty PK, Sinsheimer JE:  (1993) Quantitative Structure-activity relationships for the mutagenicity of propylene oxides with Salmonella. Mutation Research, 293:85-93.

13. Rengan R, Chakraborty PK, Kilbourn MR:  (1993) Can we predict reactivity for aromatic nucleophilic substitution with [18F]fluoride ion?  J Labeled Compds. Radiopharm., 33:563-572.

14. Chakraborty PK, Gildersleeve DL, Jewett DM, Toorongian SA, Kilbourn MR, Schwaiger M, Wieland DM:  (1993) High yield synthesis of high specific activity R-(-)[11C]epinephrine for routine PET studies in humans. Nucl. Med. Biol., 20:939-944.

15. Del Rosario R, Jung Y -W, Carahar J, Chakraborty PK, Sherman PS, Wieland DM:  (1996) Synthesis and preliminary evaluation of [C-11]phenylephrine as a functional heart neuronal PET agent. Nucl. Med. Biol. 23: 611-616.

16. Chakraborty PK, Mangner TJ, Chugani DC, Muzik O, Chugani HT:  (1996) A high-yield and simplified procedure for synthesis of a-[11C]methyl-L-tryptophan. Nucl. Med. Biol., 23:1005-1008.

17. Di Carli MF, Tobes MC, Mangner T, Levine AB, Muzik O, Chakraborty P, Levine TB:  (1997) Effects of cardiac sympathetic innervation on coronary blood flow. New England Journal of Medicine. 336:1208-1215.

18. Nguyen NTB, DeGrado TR, Chakraborty P, Wieland DM, Schwaiger M:  (1997) Myocardial kinetics of C-11 epinephrine in the isolated working rat heart. J Nucl Med., 38: 780-785.

19. Chakraborty PK, Mangner TJ, Chugani HT:  (1997) The synthesis of no-carrier-added [11C]urea from [11C]carbon dioxide and application to [11C]uracil synthesis. Applied Radiat. Isotopes. 48: 619-621.

20. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Chakraborty PK:  (1997) Language and motor functions  calcified hemisphere in parents with sturge-Weber syndrome: a PET study. J. Child Neurology. 12: 431-437.

21. Muller R-A, Rothermel RD, Muzik O, Behen ME, Chakraborty PK, Chugani HT:  (1997) Plasticity of motor organization in children and adults. Neuroreport, 8:3103-3108.

22. Muzik O, Chugani DC, Chakraborty P, Mangner T, Chugani HT :  (1997) Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J. Cereb. Blood Flow and Metab., 17:659-669. 

23. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty PK, Mangner TJ, da Silva EA, Chugani HT:  (1997) Altered serotonin synthesis in the dentatothalamo-cortical pathway in autistic boys. Annals of Neurology, 42: 666-669.

24. Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty PK, Chugani HT:  (1997) Receptive and expressive language activations for sentences: a PET study. Neuroreport, 8 3767-3770.

25. Muller R-A, Chugani DC, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT:  (1997) Impairment of dentato- thalamocortical pathway in autism: languqage activation data from PET. Neuroscience Letters, 245: 1-4.

26. Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT:  (1998) Human brain serotonin synthesis capacity measured in vivo with a-[11C]methyl-L-tryptophan. Synapse, 28: 33-43.

27. Muller R-A, Watson CE, Muzik O, daSilva E, Chakraborty PK, Chugani HT:  (1998) Motor organization after early middle cerebral artery stroke : a PET study. Ped. Neurology, 19: 294-298.

28. Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty PK, Chugani HT: Brain organization of language after early unilateral lesion. Brain and Language, 1998, 62: 422-451.

29. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AL, Mangner TJ, Chakraborty PK:  (1998) Imaging  epileptogenic tubers in children with tuberous sclerosis complex using a-[11C]methyl-L-tryptophan PET. Ann Neurol., 44:858-866.

30. Munch G, Nguyen NTB, Nekolla S, Zieglar S, Muzik O, Chakraborty P, Wieland DM, Schwaiger M:  (2000) Evaluation of sympathetic nerve terminals with [11C]epinephrine and [11C]hydroxyephedrine and positron emission tomography.  Circulation, 101: 516-523.

31. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, Mangner TJ, Chakraborty PK, Chugani HT.  (2001) Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology; 57:1269-1277.

32. Pfund Z, Chugani DC, Muzik O, Juhász C, Behen ME, Lee J, Chakraborty PK, Mangner T, Chugani HT:  (2002)  a-[11C]Methyl-L-tryptophan PET in patients with alternating hemiplegia of childhood. J Child Neurol., 17:253-260.

33. Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT:  (2003) Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology, 60:960-968.

34. Juhász C, Chugani DC, Padhye UN, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT:  (2004) Evaluation with __[11C]methyl-L-tryptophan PET for reoperation after failed epilepsy surgery. Epilepsia, 45:124-30.

35. Maiti DK, Chakraborty PK, Chugani DC, Muzik O, Mangner TJ, Chugani HT:  (2005) Synthesis procedure for routine production of [carbonyl-11C] desmethyl-WAY-100635. Applied Radiat. Isot., 62 (5): 721-727.

36. Chandana SR, Behen ME,  Juhász C, Muzik O, Rothermel RD, Thomas J. Mangner TJ, Chakraborty PK, Harry T. Chugani HT, Chugani DC:  (2005) Significance of abnormalities in developmental trajectory and asymmetry of cortical serotonin synthesis in autism.  Int J Dev Neurosci, 23: 171-182.

37. Kagawa K, Chugani DC, Asano E, Csaba Juhász C, Otto Muzik O, Aashit Shah A, Jagdish Shah J, Sandeep Sood S, William J. Kupsky WJ, Thomas J. Mangner TJ, Chakraborty PK, Chugani HT:  (2005) Epilepsy surgery outcome in children with tuberous sclerosis studied with alpha-[11C]methyl-L-tryptophan PET. Journal of Child Neurology, 20: 429-438.

38. Juhasz, Csaba; Chugani, Diane; Muzik, Otto; Wu, Dafang; Sloan, Andrew; Barger, Geoffrey; Watson, Craig; Shah, Aashit; Sood, Sandeep; Ergun, Eser; Mangner, Tom; Chakraborty, Pulak; Kupsky, William; Chugani, Harry T:  (2006) In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophan in human brain tumors. Journal of Cerebral Blood Flow & Metabolism, 26 (3): 345-347.

39. Eluvathingal, Thomas J; Behen, Michael E; Chugani, Harry T; Jannise, James; Bernardi, Bruno; Chakraborty, Pulak; Juhasz, Csaba; Muzik, Otto; Chugani, Diane C: (2006) Cerebellar lesions in tuberous sclerosis complex: Neurobehavioral and neuroimaging correlates. Journal of Child Neurology, 21 (10):846-851.

PUBLISHED ABSTRACTS:

1. Ali E, Chakraborty PK, Pakrashi SC.  Stereochemistry of some isomeric tetracyclic oxindoles by NMR spectroscopy.  International Symp. on NMR in Chemistry and Biology, Calcutta, Jan. 1982.

2. Van Dort ME, Chakraborty PK, Wieland DM, Kilbourn M.  Dopamine uptake inhibitors :  Comparison of 125I- and 18F-labeled ligands.  J Nucl Med.,1990; 31:898.

3. Coates RM, Pyun H-J, Chakraborty PK.  Stereochemistry of proton eliminations in terpine biosynthesis.  Regional ACS Meeting, Salt Lake City, June 1990.

4. Kilbourn MR, Chakraborty PK, Mourad A.  Synthesis of F-18 labeled dopamine reuptake inhibitors.  International Isotope Soc., 3rd.Central Regional Meeting, U. S. A., Oct. 1990.

5. Chakraborty PK, Kilbourn MR.  A new approach to the synthesis of no-carrier-added
fluorine-18 labeled fluorocatechols.  J Labeled Compds. Radiopharm., 1991; 30: 133.

6. Chakraborty PK, Kilbourn MR.  [F-18]Fluorination/Decarbonylation : New route to
aryl[F-18]fluorides.  J Nucl Med.,1991; 32: 1009.

7. Chakraborty PK, Gildersleeve DL, Toorongian SA, Kilbourn MR, Schwaiger M and Wieland DM.  Syntheses of [11C]epinephrine and other biogenic amines by direct methylation of normethyl precursors.  J Labeled Compds. Radiopharm., 1993; 32: 172.

8. Wieland DM, Chakraborty PK, Gildersleeve DL, Sherman PS, Carahar JM, Nguyen NTB, Hutchins GD, Schwaiger M:  Comparison of true and false neurotransmitter: Evaluation of
R-(-)-[11C]epinephrine in animals.  J Nucl Med., 1993; 34: 123.

9. Schwaiger M, Wierland DM, Muzik O, Chakraborty PK, Nguyen NTB, Stafford K, Gildersleeve DL:  Comparison of C-11 epinephrine and C-11 HED for evaluation of sympathetic neurons of the heart.  J Nucl Med., 1993; 34: 13.

10. Nguyen NTB, DeGrado TR, Chakraborty PK, Stafford K, Wieland DM, Schwaiger M:  Evaluation of C-11 epinephrine in isolated working rat heart.  J Nucl Med., 1993; 34: 45.

11. VanDort M, Chakraborty PK, Wieland DM:  Synthesis of [C-11]erythro (+) meta-hydroxyephedrine (1S,2R).  J Nucl Med., 1993; 34: 236.

12. Jewett DM , Chakraborty PK:  Preparation, handling and reactivity of [11C]methyl trilate for fast Carbon-11 radiomethylation : some new results.  J Labeled Compds. Radiopharm. 1994, 35: 97.

13. VanDort ME, Chakraborty PK, Carahar J, Gildersleeve DG, Sherman PS, Wieland DM:  Search for kinetic richness: evaluation of stereoisomers of [C-11]HED.  J Nucl Med., 1994; 35: 98

14. Del Rosario RB, Jung Y-W, Chakraborty PK, Sherman PS, Wieland DM: 
[C-11]Phenylephrine: marker for neuronal heart MAO.  J Nucl Med., 1994; 35: 7

15. Chugani DC, Mangner TJ, Muzik O, Chakraborty PK, Behrendt DB, Chugani HT:
[C-11]Flumazenil PET in children with intractable epilepsy.  Ann Neurol 36: 525-526, 1994.

16. Chugani DC, Muzik O, Mangner TJ, Chakraborty PK, Behrendt DB, Verma NP, Chugani HT:  [C-11]Flumazenil PET in patients with partial epilepsy: Effects of sedation. Epilepsia, 1994; 35 (Suppl. 8): 21

17. Chugani DC, Chugani HT,  Mangner TJ, Muzik O, Chakraborty PK:  [C-11]Flumazenil PET in children with  epilepsy. J Nucl Med., 1995; 36: 83

18. Chakraborty PK, Mangner TJ, Chugani DC, Muzik O, Chugani HT:  A high yield and simplified procedure for the synthesis of a-[11C]methyl-L-tryptophan. J Labeled Compds. Radiopharm., 1995, 37: 619

19. Muller R-A, Chugani HT, Chakraborty PK, Mangner TJ :  Activation of calcified hemisphere in Sturge-Webber patients during motor and language functions: A positron emission tomography study. Epilepsia, 1995; 36 (Suppl. 4): 109

20. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Mangner TJ, Chakraborty PK: Presurgical functional brain mapping in children's by means of 15O-water positron emission tomography. Neurology, 1995; 45 (Suppl. 4): A295-296.

21. Muller R-A, Chugani HT, Muzik O, Rothermel RD, Chakraborty PK: Localization of language functions after early perisylvian lesion: A 15O-water PET study with children and adolescents. J. Cereb. Blood Flow and Metab. 1995; 15 (Suppl. 1): S691

22. Chugani DC, Chugani HT,  Mangner TJ, Muzik O, Chakraborty PK:  Localization of epileptic foci with [11C]flumazenil PET in children. J. Cereb. Blood Flow and Metab. 1995; 15 (Suppl. 1): S179

23. Chakraborty PK, Mangner TJ, Chugani HT:  The synthesis of no-carrier-added [C-11]urea from [C-11]carbon dioxide. J. Nucl. Med. 1996; 37: 51P.

24. Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT:  Brain serotonine synthesis rate measured with _-[C-11]methyl-L-tryptophan positron tomography in normal and autistic subjects. Child Neurology Society Meeting, Sept. 1996.

25. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty PK, Mangner TJ, Chugani HT: a-[C-11]Methyl-L-tryptophan PET demonstrate increased brain serotonin rate in autistic adults. IASSID, July 1996.

26. Muzik O, Chugani DC, Chakraborty PK, Mangner TJ, Chugani HT:  Analysis of C-11 alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in human brain using dynamic PET. J. Nucl. Med. 1996; 37: 145P.

27. Chugani DC, daSilva EA, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT: Abnonormal serotonin synthesis in epileptic foci of children: An in vivo study with a-[C-11]methyl-tryptophan and positron emission tomography. Epilepsia. 1997, 38: 45.

28. Chakraborty PK, Mangner TJ, Chugani HT:  Synthesis of [2-11C]thymidine from [11C]carbon dioxide. J Labeled Compds. Radiopharm., 1997.

29. Muller R-A, Muzik O, Watson CE, daSilva E, Mangner TJ, Chakraborty PK, Chugani HT: Motor activation in the temporal lobe following perinatal middle cetrebral artery stroke-A single-case PET study. Annals of Neurology, 1997; 42: 518-519.     

30. Muller R-A, Muzik O, Rothermel RD, Behen ME, Downey R, Chakraborty PK, Chugani HT:  Finger movement in children: less distinct neocortical activation profiles and reduced cerebellar involvement compared to adults. Neuroimage, 1997, 5:S11.   

31.Muller R-A, Rothermel RD, Behen ME, Muzik O, Mangner TJ, Chakraborty PK, Chugani HT:  Receptive and expressive language activations for sentences. Neuroimage,1997 5:S545.

32. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AL, Mangner TJ, Chakraborty PK:  Identification of epileptogenic tubers in children with tuberous sclerosis complex: brain seotonin synthesis imaging with PET. Annals of Neurol., 1998, 44: 858-866.

33. Juhász C, Chugani DC, Muzik O, Asano E, Shah A, Sood S, Mangner T, Chakraborty PK, Chugani HT:  a-[11C]Methyl-L-tryptophan (AMT) PET can detect residual epileptic cortex following failed cortical resection in children with intractable epilepsy.  American Epilepsy Society Meeting, Seattle, Dec 2002.  Epilepsia 2002;43 (suppl 7):126-127.

34. Chugani HT, Juhász C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK:  Surgery for intractable infantile spasms: the role of _[11C]Methyl-L-tryptophan (AMT) PET scanning.  American Epilepsy Society Meeting, Seattle, Dec 2002. Epilepsia 2002;43 (suppl 7):75-76.

35. Maiti DK, Chakraborty PK, Mangner TJ, Chugani DC, Chugani HT:  Role of tertiary amine in the condensation reaction of 11C-DWAY and 11C-WAY synthesis. 227 th. American Chemical Society National Meeting, Medicinal Chemistry Division, 2004,p 54-55.

36. Liu J, Wu J-s, Lu X, Mangner T, Chakraborty P, Mu F, Muzik O, Peng F:  Comparative study of multiple radiopharmaceuticals for positron emission tomography of neuroblastoma. 96 th. American Association of Cancer Research Annual Meeting, Anaheim, CA, April 16-20, 2005.

37. Chakraborty PK, Maiti DK, Mangner TJ, Chugani DC, Chugani HT: High yield and semi-automated synthesis procedure of (R)-[11C]PK11195. J. Nucl. Med. 2006; 47: 522P-523P.

38. Sundaram SK, Govindan R Munian, Asano E, Juhasz C, Chakraborty PK, Muzik O, Chugani HT, Chugani DC: Alpha-[11C]methyl-L-Tryptophan Positron Emission Tomography (AMT- PET) predicts outcome in children with neocortical epilepsy. American Epilepsy Society Meeting, 2006. Epilepsia 2006;00 (suppl 0):00-00.


PRESENTATIONS:

A new approach to the synthesis of no-carrier-added fluorine-18 labeled fluorocatechol
International Symposium on Radiopharmaceutical Chemistry
Princeton, New Jersey, 1990
Platform presentation

[F-18]Fluorination/Decarbonylation: New route to aryl[F-18]fluorides
Society of Nuclear Medicine Annual Meeting, Cincinati, Ohio, 1991   
Platform presentation

PET tracers for mapping both sides of the peripheral sympathetic synapse.
Nuclear Medicine Research Conference
University of Michigan Medical School, Ann Arbor, 1992
1.0 h lecture

Synthesis of Carbon-11 and Fluorine-18 labeled biogenic amines
Veteran Administration Hospital, Minneapolis, Minnesota, 1993
1.0 h lecture

Carbon-11 labelling chemistry
Nuclear Medicine Course for Basic Scientist
University of Michigan Medical School, Ann Arbor, 1993
1.0 h lecture

The synthesis of no-carrier-added [C-11]urea from [C-11]carbon dioxide.
Society of Nuclear Medicine Annual Meeting, Denver, 1996
Platform presentation